Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors

Journal of Investigative Dermatology

Volumn 134, Issue 5, 2014, Pages 1446-1455

  Wang, Xiao Qi ^a   Lee, Sarah ^a   Wilson, Heather ^a   Seeger, Mark ^a   Iordanov, Hristo ^a   Gatla, Nandita ^a   Whittington, Adam ^a   Bach, Daniel ^a   Lu, Jian Yun ^a   Paller, Amy S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE GM3; GLUCOSE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; GANGLIOSIDE GM3 SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DEPLETION; DIABETIC FOOT; EPITHELIZATION; EXPERIMENTAL DIABETES MELLITUS; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; KERATINOCYTE; LIPID DIET; MOUSE; MOUSE MODEL; NONHUMAN; SIGNAL TRANSDUCTION; WOUND CLOSURE; WOUND HEALING IMPAIRMENT; ANIMAL TISSUE; DIABETES MELLITUS; ENZYME PHOSPHORYLATION; GLUCOSE TOLERANCE TEST; IMMUNOFLUORESCENCE; IN VITRO STUDY; INSULIN RESISTANCE; OBESITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; WOUND HEALING;

ANIMALS; CELL MOVEMENT; DIABETES MELLITUS, TYPE 2; FEMALE; G(M3) GANGLIOSIDE; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-LIKE GROWTH FACTOR I; KERATINOCYTES; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIALYLTRANSFERASES; WOUND HEALING;

EID: 84900838848     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.532     Document Type: Article

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