Lack of insulin-like growth factor I (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers

Journal of Pathology

Volumn 190, Issue 5, 2000, Pages 589-594

  Blakytny, Robert ^a   Jude, Edward B ^a,b,c   Martin Gibson, J ^b   Boulton, Andrew J M ^b   Ferguson, Mark W J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c Department of Medicine   (United Kingdom)

Author keywords

Diabetes mellitus; Diabetic foot ulcer; Diabetic neuropathy; Insulin like growth factors; immunohistochemistry

Indexed keywords

MONOCLONAL ANTIBODY; SOMATOMEDIN B; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; BASAL CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC FOOT; EPIDERMIS; EPITHELIZATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MALE; PRIORITY JOURNAL; SKIN EPITHELIUM; SKIN FIBROBLAST; WOUND HEALING IMPAIRMENT;

AGED; DIABETES MELLITUS; DIABETIC FOOT; EPIDERMIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; KERATINOCYTES; MALE; MIDDLE AGED; SKIN;

EID: 0034028713     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(200004)190:5<589::AID-PATH553>3.0.CO;2-T     Document Type: Article

References (30)

1. Goodson WH, Hunt TK. Wound healing and the diabetic patient. Surg Gynecol Obstet 1979; 149: 600-608.
2. Yue DK, Swanson B, McLennan S, et al. Abnormalities of granulation tissue and collagen formation in experimental diabetes, uraemia and malnutrition. Diabetic Med 1986; 3: 221-225.
3. Fahey TJ, Sadaty A, Jones WG, Barber A, Smoller B, Shires GT. Diabetes impairs the late inflammatory response to wound healing. J Surg Res 1991; 50: 308-313.
4. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R. PDGF and FGF stimulates wound healing in the genetically diabetic mice. Am J Pathol 1990; 136: 1235-1246.
5. Boulton AJM. Foot problems in patients with diabetes mellitus. In Textbook of diabetes. Pickup J, Williams G (eds), Blackwell Science: Oxford. 1997, 581-58.20.
6. Reiber GE, Pecoraro RH, Koepsell TD. Risk factors for amputation in patients with diabetes mellitus: a case control study. Ann Intern Med 1992; 117: 97-105.
7. Bild DE, Selby JV, Sinnock P, Browner WS, Braveman P, Showstack JA. Lower-extremity amputation in people with diabetes: epidemiology and prevention. Diabetes Care 1989; 12: 24-31.
8. Williams DRR. The size of the problem; epidemiological and economic aspects of foot problems in diabetes mellitus. In The Foot in Diabetes, Boulton AJM, Connor H, Cavanagh PR (eds). John Wiley: Chichester, 1994: 15-24.
9. Frystyk J, Ørskov H. IGF-I, IGF-II, IGF-binding proteins and diabetes. In International Textbook of Diabetes, Alberti KGMM, Zimmet AP, DeFronzo RA, Keen H (eds). John Wiley: Chichester, 1997; 417-436.
10. Tsuboi R, Shi CM, Sato C, Cox GN, Ogawa H. Coadministration of insulin-like growth factor (IGF)-I and IGF-binding protein-1 stimulates wound healing in animal models. J Invest Dermaltol 1995; 104: 199-203.
11. Bitar MS, Labbad ZN. Transforming growth factor-β and insulin-like growth factor-1 in relation to diabetes-induced impairment of wound healing. J Surg Res 1996; 61: 113-119.
12. Ceohowska-Pasko M. Palka J. Bankowski E. Alterations in glycosaminoglycans in wounded skin of diabetic rats. A possible role of IGF-1, IGF-binding proteins and proteolytic activity. Acta Biochim Pol 1996; 43: 557-565.
13. Brown DL, Kane CD, Chernausek SD, Greenhalgh DG. Differential expression and localisation of insulin-like growth factors I and II in cutaneous wounds of diabetic and nondiabetic mice. Am J Pathol 1997; 151: 715-724.
14. Crosby SR, Tsigos C, Anderton CD, Gordon C. Young RJ, White A. Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy. Diabetologia 1992; 35: 868-872.
15. Crosby SR, Anderton CD. Westwood M, et al. Measurement of insulin-like growth factor-II in human plasma using a specific monoclonal antibody-based two-site immunoradiometric assay. J Endocrinol 1993; 137: 141-150.
16. Walter JB, Israel MS. Wound Healing. General Pathology. Churchill Livingstone: Edinburgh, 1987: 117-129.
17. Gawkrodger DJ. Microanatomy of the Skin Dermatology. Churchill Livingstone: London; 1997: 2-3.
18. Jennische E, Skottner A, Hansson HA. Dynamic changes in insulin-like growth factor immunoreactivity correlate to repair events in rat ear after freeze thaw injury. Exp Mol Pathol 1987; 47: 193-201.
19. Hansson HA, Jonsson R, Petruson K. Transiently increased insulin-like growth factor-1. Immunoreactivity in UVB-irradiated mouse skin. J Invest Dermatol 1988; 91: 328-332.
20. Grant M, Jordan J, Merimee TJ. Insulin-like growth factor-1 modulates endothelial cell chemotaxis. J Clin Endocrinol Metab 1987; 65: 370-371.
21. Ristow HJ, Messmer TO. Basic fibroblast growth factor and insulin-like growth factor 1 are strong mitogens for cultured mouse keratinocytes. J Cell Physiol 1988; 137: 277-284.
22. Krane JF, Murphy DP, Carter DM, Krueger JG. Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-1) on keratinocyte proliferation may be mediated by IGF-1 transmodulation of the EGF receptor. J Invest Dermatol 1991; 96: 419-424.
23. Kratz G, Lake M, Ljungström K, Forsberg G, Hægerstrand A, Gidlund M. Effect of recombinant IGF binding protein-1 on primary cultures of human keratinocytes and libroblasts: selective enhancement of IGF-1 but not IGF-2 induced cell proliferation. Exp Cell Res 1992; 202: 381-385.
24. Bhora FY, Dunkin BJ, Batzri S, et al. Effect of growth factors on cell proliferation and epithelialisation in human skin. J Surg Res 1995; 59: 236-244.
25. Gilhar A, Ish-Shalom S, Pillar T, Etzioni A, Silbermann M. Effect of antiinsulin-like growth factor 1 on the epidermal proliferation of human skin transplanted onto nude mice treated with growth hormone. Endocrinology 1994; 134: 229-232.
26. Barreca A, de Luca M, del Monte P, et al. In vitro paracrine regulation of human keratinocyte growth by fibroblast derived insulin-like growth factors. J Cell Physiol 1992; 151: 262-268.
27. Jyung RW, Mustoe JA, Busby WH, Clemmons DR. Increased wound-breaking strength induced by insulin-like growth factor 1 in combination with insulin-like growth factor binding protein-1. Surgery 1994; 115: 233-239.
28. Galiano RD, Zhao LL, Clemmons DR, Roth SI, Lin X, Mustoe JA. Interaction between the insulin-like growth factor family and the integrin family in tissue repair processes. J Clin Invest 1996; 98: 2462-2468.
29. Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A 1991; 88: 580-584.
30. Jude EB, Boulton AJM, Ferguson MWJ, Appleton I. The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects of transforming growth factor β1. Diabetologia 1999; 42: 748-757.