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Volumn 39, Issue 6, 2014, Pages 1355-1365

Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates

Author keywords

5 HT depletion; 5 HT transporter (SERT); serotonin (5 HT) release; SERT substrate; SERT mediated current

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; DEXFENFLURAMINE; DOPAMINE; DRUG METABOLITE; FENFLURAMINE; FLUOXETINE; PARGYLINE; SEROTONIN; SEROTONIN TRANSPORTER; TRITIUM; 1-(3-CHLOROPHENYL)PIPERAZINE; 1-(3-TRIFLUOROMETHYLPHENYL)PIPERAZINE; PIPERAZINE DERIVATIVE; SEROTONIN RECEPTOR AFFECTING AGENT; SLC6A4 PROTEIN, RAT;

EID: 84900833796     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.331     Document Type: Article
Times cited : (35)

References (69)
  • 1
    • 0041821557 scopus 로고    scopus 로고
    • Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis
    • Adams SV, Defelice LJ (2003). Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis. Biophys J 85: 1548-1559. (Pubitemid 37052241)
    • (2003) Biophysical Journal , vol.85 , Issue.3 , pp. 1548-1559
    • Adams, S.V.1    DeFelice, L.J.2
  • 2
    • 0025090790 scopus 로고
    • Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: Assessment using quantitative autoradiography
    • DOI 10.1002/syn.890060105
    • Appel NM, Mitchell WM, Contrera JF, De Souza EB (1990). Effects of high-dose fenfluramine treatment on monoamine uptake sites in rat brain: assessment using quantitative autoradiography. Synapse 6: 33-44. (Pubitemid 20270696)
    • (1990) Synapse , vol.6 , Issue.1 , pp. 33-44
    • Appel, N.M.1    Mitchell, W.M.2    Contrera, J.F.3    De Souza, E.B.4
  • 4
    • 0035083653 scopus 로고    scopus 로고
    • 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain
    • DOI 10.1016/S0893-133X(00)00221-9, PII S0893133X00002219
    • Baumann MH, Ayestas MA, Dersch CM, Rothman RB (2001). 1-(M-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain. Neuropsychopharmacology 24: 492-501. (Pubitemid 32244310)
    • (2001) Neuropsychopharmacology , vol.24 , Issue.5 , pp. 492-501
    • Baumann, M.H.1    Ayestas, M.A.2    Dersch, C.M.3    Rothman, R.B.4
  • 5
    • 84858335179 scopus 로고    scopus 로고
    • The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue
    • Baumann MH, Ayestas MA, Partilla JS, Sink JR, Shulgin AT, Daley PF et al (2012). The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 37: 1192-1203.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1192-1203
    • Baumann, M.H.1    Ayestas, M.A.2    Partilla, J.S.3    Sink, J.R.4    Shulgin, A.T.5    Daley, P.F.6
  • 6
    • 13944249599 scopus 로고    scopus 로고
    • N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-Methylenedioxymethamphetamine (MDMA, or 'Ecstasy')
    • DOI 10.1038/sj.npp.1300585
    • Baumann MH, Clark RD, Budzynski AG, Partilla JS, Blough BE, Rothman RB (2005). N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy'). Neuropsychopharmacology 30: 550-560. (Pubitemid 40271157)
    • (2005) Neuropsychopharmacology , vol.30 , Issue.3 , pp. 550-560
    • Baumann, M.H.1    Clark, R.D.2    Budzynski, A.G.3    Partilla, J.S.4    Blough, B.E.5    Rothman, R.B.6
  • 7
    • 84873742824 scopus 로고    scopus 로고
    • Powerful cocaine-like actions of 3, 4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products
    • Baumann MH, Partilla JS, Lehner KR, Thorndike EB, Hoffman AF, Holy M et al (2013). Powerful cocaine-like actions of 3, 4-Methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products. Neuropsychopharmacology 38: 552-562.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 552-562
    • Baumann, M.H.1    Partilla, J.S.2    Lehner, K.R.3    Thorndike, E.B.4    Hoffman, A.F.5    Holy, M.6
  • 8
    • 0027729225 scopus 로고
    • Intravenous administration of the serotonin agonist m- chlorophenylpiperazine (mCPP) increases extracellular serotonin in the diencephalon of awake rats
    • DOI 10.1016/0028-3908(93)90034-Z
    • Baumann MH, Rutter JJ, Auerbach SB (1993). Intravenous administration of the serotonin agonist m-chlorophenylpiperazine (mCPP) increases extracellular serotonin in the diencephalon of awake rats. Neuropharmacology 32: 1381-1386. (Pubitemid 24023022)
    • (1993) Neuropharmacology , vol.32 , Issue.12 , pp. 1381-1386
    • Baumann, M.H.1    Ruiter, J.J.2    Auerbach, S.B.3
  • 9
    • 0026534558 scopus 로고
    • The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5- hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine
    • Berger UV, Gu XF, Azmitia EC (1992). The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5- hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. Eur J Pharmacol 215: 153-160.
    • (1992) Eur J Pharmacol , vol.215 , pp. 153-160
    • Berger, U.V.1    Gu, X.F.2    Azmitia, E.C.3
  • 10
    • 84861541137 scopus 로고    scopus 로고
    • The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters
    • Bulling S, Schicker K, Zhang Y-W, Steinkellner T, Stockner T, Gruber CW et al (2012). The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem 287: 18524-18534.
    • (2012) J Biol Chem , vol.287 , pp. 18524-18534
    • Bulling, S.1    Schicker, K.2    Zhang, Y.-W.3    Steinkellner, T.4    Stockner, T.5    Gruber, C.W.6
  • 12
    • 0031200869 scopus 로고    scopus 로고
    • Free radicals and the pathobiology of brain dopamine systems
    • DOI 10.1016/S0197-0186(97)00031-4, PII S0197018697000314
    • Cadet JL, Brannock C (1998). Free radicals and the pathobiology of brain dopamine systems. Neurochem Int 32: 117-131. (Pubitemid 28105298)
    • (1998) Neurochemistry International , vol.32 , Issue.2 , pp. 117-131
    • Cadet, J.L.1    Brannock, C.2
  • 15
    • 0030986255 scopus 로고    scopus 로고
    • In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine
    • DOI 10.1038/sj.bjp.0701213
    • Colado MI, O'Shea E, Granados R, Murray TK, Green AR (1997). In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. Br J Pharmacol 121: 889-900. (Pubitemid 27277782)
    • (1997) British Journal of Pharmacology , vol.121 , Issue.5 , pp. 889-900
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Murray, T.K.4    Green, A.R.5
  • 16
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins DL, Vosmer G, Virus RM, Woolverton WL, Schuster CR, Seiden LS (1987). Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241: 338-345. (Pubitemid 17119380)
    • (1987) Journal of Pharmacology and Experimental Therapeutics , vol.241 , Issue.1 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.M.3
  • 18
    • 0034598969 scopus 로고    scopus 로고
    • Characterization of D-fenfluramine-induced hypothermia: Evidence for multiple sites of action
    • DOI 10.1016/S0014-2999(00)00012-1, PII S0014299900000121
    • Cryan JF, Harkin A, Naughton M, Kelly JP, Leonard BE (2000). Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action. Eur J Pharmacol 390: 275-285. (Pubitemid 30119942)
    • (2000) European Journal of Pharmacology , vol.390 , Issue.3 , pp. 275-285
    • Cryan, J.F.1    Harkin, A.2    Naughton, M.3    Kelly, J.P.4    Leonard, B.E.5
  • 19
    • 0032902870 scopus 로고    scopus 로고
    • Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain
    • DOI 10.1016/S0893-133X(98)00070-0, PII S0893133X98000700
    • Eriksson E, Engberg G, Bing O, Nissbrandt H (1999). Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain. Neuropsychopharmacology 20: 287-296. (Pubitemid 29067408)
    • (1999) Neuropsychopharmacology , vol.20 , Issue.3 , pp. 287-296
    • Eriksson, E.1    Engberg, G.2    Bing, O.3    Nissbrandt, H.4
  • 20
    • 0016615365 scopus 로고
    • On the in vivo and in vitro actions of fenfluramine and its derivatives on central monoamine neurons, especially 5-hydroxytryptamine neurons, and their relation to the anorectic activity of fenfluramine
    • Fuxe K, Farnebo LO, Hamberger B, Ogren SO (1975). On the in vivo and in vitro actions of fenfluramine and its derivatives on central monoamine neurons, especially 5-hydroxytryptamine neurons, and their relation to the anorectic activity of fenfluramine. Postgrad Med J 51(Suppl 1): 35-45.
    • (1975) Postgrad Med J , vol.51 , Issue.SUPPL. 1 , pp. 35-45
    • Fuxe, K.1    Farnebo, L.O.2    Hamberger, B.3    Ogren, S.O.4
  • 21
  • 23
    • 0030593704 scopus 로고    scopus 로고
    • Down-regulation of rat brain 5-HT uptake carriers after treatment with high doses of D-fenfluramine
    • DOI 10.1016/S0006-8993(96)00435-0
    • Gobbi M, Mancini L, Presti ML, Mennini T (1996). Downregulation of rat brain 5-HT uptake carriers after treatment with high doses of D-fenfluramine. Brain Res 730: 165-172. (Pubitemid 26305336)
    • (1996) Brain Research , vol.730 , Issue.1-2 , pp. 165-172
    • Gobbi, M.1    Mancini, L.2    Presti, M.L.3    Mennini, T.4
  • 24
    • 0035163183 scopus 로고    scopus 로고
    • Role of monoamine oxidase inhibition and monoamine depletion in fenfluramine-induced neurotoxicity and serotonin release
    • Halladay AK, Kirschner E, Hesse K, Fisher H, Wagner GC (2001). Role of monoamine oxidase inhibition and monoamine depletion in fenfluramine-induced neurotoxicity and serotonin release. Pharmacol Toxicol 89: 237-248. (Pubitemid 33070924)
    • (2001) Pharmacology and Toxicology , vol.89 , Issue.5 , pp. 237-248
    • Wagner, G.C.1
  • 25
    • 26944489620 scopus 로고    scopus 로고
    • Serotonin-transporter mediated efflux: A pharmacological analysis of amphetamines and non-amphetamines
    • DOI 10.1016/j.neuropharm.2005.08.008, PII S002839080500314X, New Perspectives in Neurotransmitter Transporter Biology
    • Hilber B, Scholze P, Dorostkar MM, Sandtner W, Holy M, Boehm S et al (2005). Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines. Neuropharmacology 49: 811-819. (Pubitemid 41483887)
    • (2005) Neuropharmacology , vol.49 , Issue.6 , pp. 811-819
    • Hilber, B.1    Scholze, P.2    Dorostkar, M.M.3    Sandtner, W.4    Holy, M.5    Boehm, S.6    Singer, E.A.7    Sitte, H.H.8
  • 26
    • 0036784803 scopus 로고    scopus 로고
    • Dopamine transportermediated conductances increase excitability of midbrain dopamine neurons
    • Ingram SL, Prasad BM, Amara SG (2002). Dopamine transportermediated conductances increase excitability of midbrain dopamine neurons. Nat Neurosci 5: 971-978.
    • (2002) Nat Neurosci , vol.5 , pp. 971-978
    • Ingram, S.L.1    Prasad, B.M.2    Amara, S.G.3
  • 27
    • 0020041082 scopus 로고
    • Is receptor activation involved in the mechamism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain?
    • Invernizzi R, Kmieciak-Kolada K, Samanin R (1982). Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol 75: 525-530. (Pubitemid 12191874)
    • (1982) British Journal of Pharmacology , vol.75 , Issue.3 , pp. 525-530
    • Invernizzi, R.1    Kmieciak-Kolada, K.2    Samanin, R.3
  • 28
    • 0025918369 scopus 로고
    • 3H monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues
    • Johnson MP, Conarty PF, Nichols DE (1991). [3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues. Eur J Pharmacol 200: 9-16.
    • (1991) Eur J Pharmacol , vol.200 , pp. 9-16
    • Johnson, M.P.1    Conarty, P.F.2    Nichols, D.E.3
  • 29
    • 0025092569 scopus 로고
    • Behavioral, biochemical and neurotoxicological actions of the α-ethyl homologue of p-chloroamphetamine
    • Johnson MP, Huang XM, Oberlender R, Nash JF, Nichols DE (1990). Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. Eur J Pharmacol 191: 1-10. (Pubitemid 20386119)
    • (1990) European Journal of Pharmacology , vol.191 , Issue.1 , pp. 1-10
    • Johnson, M.P.1    Huang, X.2    Oberlender, R.3    Nash, J.F.4    Nichols, D.E.5
  • 30
    • 0025277008 scopus 로고
    • Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine
    • DOI 10.1016/0091-3057(90)90133-3
    • Johnson MP, Nichols DE (1990). Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine. Pharmacol Biochem Behav 36: 105-109. (Pubitemid 20165643)
    • (1990) Pharmacology Biochemistry and Behavior , vol.36 , Issue.1 , pp. 105-109
    • Johnson, M.P.1    Nichols, D.E.2
  • 32
    • 0024788704 scopus 로고
    • D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain
    • DOI 10.1016/0006-8993(89)91467-4
    • Kleven MS, Seiden LS (1989). D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain. Brain Res 505: 351-353. (Pubitemid 20013179)
    • (1989) Brain Research , vol.505 , Issue.2 , pp. 351-353
    • Kleven, M.S.1    Seiden, L.S.2
  • 33
    • 0037651952 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: Cellular and molecular mechanisms
    • DOI 10.1016/S0165-0173(03)00173-5
    • Lyles J, Cadet JL (2003). Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res Brain Res Rev 42: 155-168. (Pubitemid 36549174)
    • (2003) Brain Research Reviews , vol.42 , Issue.2 , pp. 155-168
    • Lyles, J.1    Cadet, J.L.2
  • 35
    • 0030821780 scopus 로고    scopus 로고
    • Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles
    • DOI 10.1016/S0006-8993(97)00517-9, PII S0006899397005179
    • Malberg JE, Seiden LS (1997). Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles. Brain Res 765: 101-107. (Pubitemid 27374919)
    • (1997) Brain Research , vol.765 , Issue.1 , pp. 101-107
    • Malberg, J.E.1    Seiden, L.S.2
  • 36
    • 0030867864 scopus 로고    scopus 로고
    • Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine: A systematic review of the evidence
    • McCann UD, Seiden LS, Rubin LJ, Ricaurte GA (1997). Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence. JAMA 278: 666-672. (Pubitemid 27373842)
    • (1997) Journal of the American Medical Association , vol.278 , Issue.8 , pp. 666-672
    • McCann, U.D.1    Seiden, L.S.2    Rubin, L.J.3    Ricaurte, G.A.4
  • 37
    • 9644295740 scopus 로고    scopus 로고
    • Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter
    • DOI 10.1074/jbc.M407660200
    • Meinild A-K, Sitte HH, Gether U (2004). Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. J Biol Chem 279: 49671-49679. (Pubitemid 39577770)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.48 , pp. 49671-49679
    • Meinild, A.-K.1    Sitte, H.H.2    Gether, U.3
  • 38
    • 0030458376 scopus 로고    scopus 로고
    • The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine
    • DOI 10.1016/S0028-3908(96)00118-9, PII S0028390896001189
    • Murray TK, Williams JL, Misra A, Colado MI, Green AR (1996). The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine. Neuropharmacology 35: 1615-1620. (Pubitemid 27026490)
    • (1996) Neuropharmacology , vol.35 , Issue.11 , pp. 1615-1620
    • Murray, T.K.1    Williams, J.L.2    Misra, A.3    Colado, M.I.4    Green, A.R.5
  • 41
    • 0021255771 scopus 로고
    • Serotonin-releasing effects of substituted piperazines in vitro
    • DOI 10.1016/0006-2952(84)90424-6
    • Pettibone DJ, Williams M (1984). Serotonin-releasing effects of substituted piperazines in vitro. Biochem Pharmacol 33: 1531-1535. (Pubitemid 14105029)
    • (1984) Biochemical Pharmacology , vol.33 , Issue.9 , pp. 1531-1535
    • Pettibone, D.J.1    Williams, M.2
  • 42
    • 84872525056 scopus 로고    scopus 로고
    • A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content
    • Rosenauer R, Luf A, Holy M, Freissmuth M, Schmid R, Sitte HH (2013). A combined approach using transporter-flux assays and mass spectrometry to examine psychostimulant street drugs of unknown content. ACS Chem Neurosci 4: 182-190.
    • (2013) ACS Chem Neurosci , vol.4 , pp. 182-190
    • Rosenauer, R.1    Luf, A.2    Holy, M.3    Freissmuth, M.4    Schmid, R.5    Sitte, H.H.6
  • 43
    • 0033600538 scopus 로고    scopus 로고
    • Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates: Implications for primary pulmonary hypertension
    • Rothman RB, Ayestas MA, Dersch CM, Baumann MH (1999). Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation 100: 869-875. (Pubitemid 29398887)
    • (1999) Circulation , vol.100 , Issue.8 , pp. 869-875
    • Rothman, R.B.1    Ayestas, M.A.2    Dersch, C.M.3    Baumann, M.H.4
  • 44
    • 0035993478 scopus 로고    scopus 로고
    • Therapeutic and adverse actions of serotonin transporter substrates
    • Rothman RB, Baumann MH (2002). Therapeutic and adverse actions of serotonin transporter substrates. Pharmacol Ther 95: 73-88.
    • (2002) Pharmacol Ther , vol.95 , pp. 73-88
    • Rothman, R.B.1    Baumann, M.H.2
  • 45
    • 67649379367 scopus 로고    scopus 로고
    • Serotonergic drugs and valvular heart disease
    • Rothman RB, Baumann MH (2009). Serotonergic drugs and valvular heart disease. Expert Opin Drug Saf 8: 317-329.
    • (2009) Expert Opin Drug Saf , vol.8 , pp. 317-329
    • Rothman, R.B.1    Baumann, M.H.2
  • 46
    • 0035218082 scopus 로고    scopus 로고
    • Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin
    • Rothman RB, Baumann MH, Dersch CM, Romero DV, Rice KC, Carroll FI et al (2001). Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse 39: 32-41.
    • (2001) Synapse , vol.39 , pp. 32-41
    • Rothman, R.B.1    Baumann, M.H.2    Dersch, C.M.3    Romero, D.V.4    Rice, K.C.5    Carroll, F.I.6
  • 47
    • 0034610435 scopus 로고    scopus 로고
    • Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
    • Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ et al (2000). Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 102: 2836-2841.
    • (2000) Circulation , vol.102 , pp. 2836-2841
    • Rothman, R.B.1    Baumann, M.H.2    Savage, J.E.3    Rauser, L.4    McBride, A.5    Hufeisen, S.J.6
  • 49
    • 0038137478 scopus 로고    scopus 로고
    • (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters
    • DOI 10.1124/jpet.103.049684
    • Rothman RB, Clark RD, Partilla JS, Baumann MH (2003). (+)- Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther 305: 1191-1199. (Pubitemid 36617998)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.305 , Issue.3 , pp. 1191-1199
    • Rothman, R.B.1    Clark, R.D.2    Partilla, J.S.3    Baumann, M.H.4
  • 51
    • 0026686602 scopus 로고
    • Fluoxetine attenuates the DL-fenfluramine-induced increase in extracellular serotonin as measured by in vivo dialysis
    • Sabol KE, Richards JB, Seiden LS (1992). Fluoxetine attenuates the DL-fenfluramine-induced increase in extracellular serotonin as measured by in vivo dialysis. Brain Res 585: 421-424.
    • (1992) Brain Res , vol.585 , pp. 421-424
    • Sabol, K.E.1    Richards, J.B.2    Seiden, L.S.3
  • 52
    • 0016417261 scopus 로고
    • Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms
    • Sanders-Bush E, Bushing JA, Sulser F (1975). Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms. J Pharmacol Exp Ther 192: 33-41.
    • (1975) J Pharmacol Exp Ther , vol.192 , pp. 33-41
    • Sanders-Bush, E.1    Bushing, J.A.2    Sulser, F.3
  • 54
    • 0025196107 scopus 로고
    • Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats
    • Schmidt CJ, Abbate GM, Black CK, Taylor VL (1990). Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats. J Pharmacol Exp Ther 255: 478-483.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 478-483
    • Schmidt, C.J.1    Abbate, G.M.2    Black, C.K.3    Taylor, V.L.4
  • 55
    • 0024308974 scopus 로고
    • Interaction of arylpiperazines with 5-HT(1A), 5-HT(1B), 5-HT(1C) and 5-HT(1D) receptors: Do discriminatory 5-HT(1B) receptor ligands exist?
    • Schoeffter P, Hoyer D (1989). Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch Pharmacol 339: 675-683. (Pubitemid 19159826)
    • (1989) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.339 , Issue.6 , pp. 675-683
    • Schoeffter, P.1    Hoyer, D.2
  • 56
    • 0027731280 scopus 로고
    • Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters
    • Schuldiner S, Steiner-Mordoch S, Yelin R, Wall SC, Rudnick G (1993). Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Mol Pharmacol 44: 1227-1231. (Pubitemid 24008607)
    • (1993) Molecular Pharmacology , vol.44 , Issue.6 , pp. 1227-1231
    • Schuldiner, S.1    Steiner-Mordoch, S.2    Yelin, R.3    Wall, S.C.4    Rudnick, G.5
  • 57
    • 0024581868 scopus 로고
    • Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis
    • DOI 10.1016/0006-8993(89)91189-X
    • Schwartz D, Hernandez L, Hoebel BG (1989). Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain Res 482: 261-270. (Pubitemid 19066538)
    • (1989) Brain Research , vol.482 , Issue.2 , pp. 261-270
    • Schwartz, D.1    Hernandez, L.2    Hoebel, B.G.3
  • 58
    • 0029682999 scopus 로고    scopus 로고
    • Methamphetamine and methylenedioxymethamphetamine neurotoxicity: Possible mechanisms of cell destruction
    • Seiden LS, Sabol KE (1996). Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction. NIDA Res Monogr 163: 251-276.
    • (1996) NIDA Res Monogr , vol.163 , pp. 251-276
    • Seiden, L.S.1    Sabol, K.E.2
  • 59
    • 0028114651 scopus 로고
    • P-Chloroamphetamine (PCA), 3,4-methylenedioxymethamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine-evoked release of 5-HT in vivo
    • DOI 10.1007/BF02247485
    • Series HG, Cowen PJ, Sharp T (1994). p-Chloroamphetamine (PCA), 3,4-methylenedioxy-methamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine-evoked release of 5-HT in vivo. Psychopharmacology (Berl) 116: 508-514. (Pubitemid 24374254)
    • (1994) Psychopharmacology , vol.116 , Issue.4 , pp. 508-514
    • Series, H.G.1    Cowen, P.J.2    Sharp, T.3
  • 60
    • 0034193379 scopus 로고    scopus 로고
    • Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors
    • Shi WX, Pun CL, Zhang XX, Jones MD, Bunney BS (2000). Dual effects of D-amphetamine on dopamine neurons mediated by dopamine and nondopamine receptors. J Neurosci 20: 3504-3511. (Pubitemid 30263765)
    • (2000) Journal of Neuroscience , vol.20 , Issue.9 , pp. 3504-3511
    • Shi, W.-X.1    Pun, C.-L.2    Zhang, X.-X.3    Jones, M.D.4    Bunney, B.S.5    Shi, W.-X.6
  • 61
    • 0033953794 scopus 로고    scopus 로고
    • Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: A superfusion study
    • Sitte HH, Scholze P, Schloss P, Pifl C, Singer EA (2000). Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study. J Neurochem 74: 1317-1324. (Pubitemid 30104331)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.3 , pp. 1317-1324
    • Sitte, H.H.1    Scholze, P.2    Schloss, P.3    Pifl, C.4    Singer, E.A.5
  • 62
    • 0031749512 scopus 로고    scopus 로고
    • An integrated hypothesis for the serotonergic axonal loss induced by 3,4- methylenedioxymethamphetamine
    • Sprague JE, Everman SL, Nichols DE (1998). An integrated hypothesis for the serotonergic axonal loss induced by 3,4- methylenedioxymethamphetamine. Neurotoxicology 19: 427-441.
    • (1998) Neurotoxicology , vol.19 , pp. 427-441
    • Sprague, J.E.1    Everman, S.L.2    Nichols, D.E.3
  • 63
    • 1642457236 scopus 로고    scopus 로고
    • Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP): In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes
    • DOI 10.1016/j.bcp.2003.08.029
    • Staack RF, Paul LD, Springer D, Kraemer T, Maurer HH (2004). Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl) piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes. Biochem Pharmacol 67: 235-244. (Pubitemid 38112754)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.2 , pp. 235-244
    • Staack, R.F.1    Paul, L.D.2    Springer, D.3    Kraemer, T.4    Maurer, H.H.5
  • 64
    • 78651366871 scopus 로고    scopus 로고
    • The ugly side of amphetamines: Short- and long-term toxicity of 3,4- methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine
    • Steinkellner T, Freissmuth M, Sitte HH, Montgomery T (2011). The ugly side of amphetamines: short- and long-term toxicity of 3,4- methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine. Biol Chem 392: 103-115.
    • (2011) Biol Chem , vol.392 , pp. 103-115
    • Steinkellner, T.1    Freissmuth, M.2    Sitte, H.H.3    Montgomery, T.4
  • 65
    • 0018579355 scopus 로고
    • Long-term effects of fenfluramine on central serotonergic mechanism
    • DOI 10.1016/0028-3908(79)90088-1
    • Steranka LR, Sanders-Bush E (1979). Long-term effects of fenfluramine on central serotonergic mechanisms. Neuropharmacology 18: 895-903. (Pubitemid 10188997)
    • (1979) Neuropharmacology , vol.18 , Issue.11 , pp. 895-903
    • Steranka, L.R.1    Sanders-Bush, E.2
  • 66
    • 79951702177 scopus 로고    scopus 로고
    • How addictive drugs disrupt presynaptic dopamine neurotransmission
    • Sulzer D (2011). How addictive drugs disrupt presynaptic dopamine neurotransmission. Neuron 69: 628-649.
    • (2011) Neuron , vol.69 , pp. 628-649
    • Sulzer, D.1
  • 67
    • 0034813505 scopus 로고    scopus 로고
    • A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: Possible relevance to the serotonergic neurotoxicity of methamphetamine
    • DOI 10.1021/tx010037c
    • Wrona MZ, Dryhurst G (2001). A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine. Chem Res Toxicol 14: 1184-1192. (Pubitemid 32911456)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.9 , pp. 1184-1192
    • Wrona, M.Z.1    Dryhurst, G.2
  • 68
    • 33746088858 scopus 로고    scopus 로고
    • Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines
    • DOI 10.1038/sj.npp.1301031, PII 1301031
    • Xie T, Tong L, McLane MW, Hatzidimitriou G, Yuan J, McCann U et al (2006). Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology 31: 2639-2651. (Pubitemid 44764161)
    • (2006) Neuropsychopharmacology , vol.31 , Issue.12 , pp. 2639-2651
    • Xie, T.1    Tong, L.2    McLane, M.W.3    Hatzidimitriou, G.4    Yuan, J.5    McCann, U.6    Ricaurte, G.7
  • 69
    • 0025267248 scopus 로고
    • Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: Pharmacokinetic, dose response, regional specificity and time course data
    • Zaczek R, Battaglia G, Culp S, Appel NM, Contrera JF, De Souza EB (1990). Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data. J Pharmacol Exp Ther 253: 104-112. (Pubitemid 20141485)
    • (1990) Journal of Pharmacology and Experimental Therapeutics , vol.253 , Issue.1 , pp. 104-112
    • Zaczek, R.1    Battaglia, G.2    Culp, S.3    Appel, N.M.4    Contrera, J.F.5    De Souza, E.B.6


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