Administration of fenfluramine at different ambient temperatures produces different core temperature and 5-HT neurotoxicity profiles

Brain Research

Volumn 765, Issue 1, 1997, Pages 101-107

  Malberg, Jessica E ^a   Seiden, Lewis S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

5 HT; 5 HIAA; Amphetamine; Neurotoxicity; Penfluramine; Temperature; Thermoregulation

Indexed keywords

FENFLURAMINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORE TEMPERATURE; DRUG EFFECT; HYPERTHERMIA; HYPOTHERMIA; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE REGULATION; BRAIN; BRAIN CHEMISTRY; CELL DEATH; FENFLURAMINE; FEVER; HYDROXYINDOLEACETIC ACID; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; TEMPERATURE; TIME FACTORS;

EID: 0030821780     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00517-9     Document Type: Article

References (35)

1. Atkinson R.L., Hubbard V.S. Report on the NIH workshop on pharmacologic treatment for obesity. Am. J. Clin. Nutr. 60:1994;153-156.
2. Berger U.V., Gu X.F., Azmitia E.C. The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. Eur. J. Pharmacol. 215:1992;153-160.
3. Bowyer J.F., Davies D.L., Schmued L., Broening H.W., Newport G.D., Slikker W.J., Holson R.R. Further studies of the role of hyperthermia in methamphetamine neurotoxicity. J. Pharmacol. Exp. Ther. 268:1994;1571-1580.
4. Bowyer J.F., Gough B., Slikker W.J., Lipe G.W., Newport G.D., Holson R.R. Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats. Pharmacol. Biochem. Behav. 44:1993;87-98.
5. Bowyer J.F., Tank A.W., Newport G.D., Slikker W.J., Ali S.F., Holson R.R. The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum. J. Pharmacol. Exp. Ther. 260:1992;817-824.
6. Caccia S., Ballabio M., Guiso G., Rocchetti M., Garattini S. Species differences in the kinetics and metabolism of fenfluramine. Arch. Int. Pharmacodyn. Ther. 258:1982;15-28.
7. Dafters R.I. Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') in rats. Psychopharmacology. 114:1994;505-508.
8. Farfel G.M., Seiden L.S. Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan J. Pharmacol. Exp. Ther. 272:1995;868-875.
9. Frey H.H. Hyperthermia induced by amphetamine, p-chloroamphetamine and fenfluramine in the rat. Pharmacology. 13:1975;163-176.
10. Fuller R.W., Snoddy H.D., Hemrick S.K. Effects of fenfluramine and norfenfluramine on brain serotonin metabolism in rats. Proc. Soc. Exp. Biol. Med. 157:1978;202-205.
11. Gordon C.J., Watkinson W.P., O'Callaghan J.P., Miller D.B. Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat. Pharmacol. Biochem. Behav. 38:1991;339-344.
12. Heffner T.G., Hartman J.A., Seiden L.S. Rapid method for the regional dissection of rat brain. Pharmacol. Biochem. Behav. 13:1980;453-456.
13. Jespersen S., Bonaccorsi A., Garattini S. Fenfluramine and body temperature. J. Pharm. Pharmacol. 21:1969;558.
14. Jonsson J., Gunne L.M. Interaction of fenfluramine with D-amphetamine-induced excitatory behaviour and hyperthermia. Eur. J. Pharmacol. 19:1972;52-55.
15. Kleven M.S., Schuster C.R., Seiden L.S. Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine. J. Pharmacol. Exp. Ther. 246:1988;822-828.
16. Kotake C., Heffner T., Vosmer G., Seiden L.S. Determination of dopamine, norepinephrine, serotonin and their major metabolic products in rat brain by reverse phase ion pair high performance liquid chromatography with electrochemical detection. Pharmacol. Biochem. Behav. 22:1985;85-89.
17. Ma S.W.Y., Preston E. Disparate effects of fenfluramine on thermogenesis in brown adipose tissue in the rat. Can. J. Physiol. Pharmacol. 70:1992;214-218.
18. Malberg J.E., Sabol K.E., Seiden L.S.S. Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat. J. Pharmacol. Exp. Ther. 278:1996;258-267.
19. Malberg J.E., Seiden L.S. 3,4-Methylenedioxymethamphetamine (MDMA) 5HT neurotoxicity is a function of ambient temperature and core body temperature in rats. Soc. Neurosci. Abstr. 3:1996;1916.
20. McCann U., Yuan J., Ricaurte G. Fenfluramine's appetite suppression and serotonin neurotoxicity are separable. Eur. J. Pharmacol. 283:1995;R5-R7.
21. McKenna D.J., Guan X.M., Shulgin A.T. 3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine. Pharmacol. Biochem. Behav. 38:1991;505-512.
22. D.B. Miller, K.F. Jensen, J.P. O'Callaghan, Effects of methylenedioxymethamphetamine (MDMA) and fenfluramine (FFA) on motor activity, body temperature and weight-characteristics of acute and repeated dosing, Soc. Neurosci. Abstr. 17/2 (1991) 1429.
23. Miller D.B., O'Callaghan J.P. Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. J. Pharmacol. Exp. Ther. 270:1994;752-760.
24. Miller D.B., O'Callaghan J.P. The role of temperature, stress and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine. Mol. Neurobiol. 11:1995;177-192.
25. Molliver D.C., Molliver M.E. Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat. Brain Res. 511:1990;165-168.
26. Preston E., Ma S., Hass N. Ambient temperature modulation of fenfluramine-induced thermogenesis in the rat. Neuropharmacology. 29:1990;277-283.
27. Schuster C.R., Lewis M., Seiden L.S. Fenfluramine: neurotoxicity. Psychopharmacol. Bull. 22:1986;148-151.
28. L.S. Seiden, K.E. Sabol, Neurotoxicity of methamphetamine-related drugs and cocaine, in: L.W. Chang, R.S. Dyer (Eds.), Handbook of Neurotoxicology, Marcel Dekker, New York, 1995.
29. Seiden L.S., Sabol K.E., Ricaurte G.A. Amphetamine: effects on catecholamine systems and behavior. [Review]. Annu. Rev. Pharmacol. Toxicol. 33:1993;639-677.
30. Steranka L.R., Sanders-Bush E. Long-term effects of fenfluramine on central serotonergic mechanisms. Neuropharmacology. 18:1979;895-903.
31. Stewart C.W., Clausing P., Bowyer J.F., Slikker W. Elevations in body temperature that are induced by D-fenfluramine (D-FEN) exposure correlate with decreasing concentrations of serotonin (5-HT). Soc. Neurosci. Abstr. 1:1996;612.
32. Sugrue M.F. Antagonism of fenfluramine-induced hyperthermia in rats by some, but not all, selective inhibitors of 5-hydroxytryptamine uptake. Br. J. Pharmacol. 81:1984;651-657.
33. Westphalen R.I., P.R. D. New evidence for a loss of serotonergic nerve terminals in rats treated with D,L-fenfluramine. Pharmacol. Toxicol. 72:1993;249-255.
34. Yehuda S., Wurtman R.J. The effects of D-amphetamine and related drugs on colonic temperatures of rats kept as various ambient temperatures. Life Sci. 11:1972;851-859.
35. Zaczek R., Battaglia G., Culp S., Appel N.M., Contrera J.F., DeSouza E.B. Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: Pharmacokinetic, dose response, regional specificity and time course data. J. Pharmacol. Exp. Ther. 253:1990;104-112.