N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents

Journal of Neurochemistry

Volumn 105, Issue 5, 2008, Pages 1770-1780

  Gobbi, Marco ^a   Funicello, Marcella ^a   Gerstbrein, Klaus ^b   Holy, Marion ^b   Moya, Pablo R ^c   Sotomayor, Ramón ^d   Forray, María Inés ^d   Gysling, Katia ^d   Paluzzi, Silvio ^e   Bonanno, Giambattista ^e   Reyes Parada, Miguel ^f   Sitte, Harald H ^b   Mennini, Tiziana ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

Author keywords

Methyl thioamphetamine; N,N dimethyl thioamphetamine; Neurotoxicity; p Cl amphetamine; Serotonin release; Serotonin transporters

Indexed keywords

AMPHETAMINE DERIVATIVE; CHLORAMPHETAMINE; METHYLTHIOAMPHETAMINE; N,N DIMETHYLTHIOAMPHETAMINE; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NEUROTOXICITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SEROTONIN RELEASE; SEROTONIN UPTAKE; SYNAPTOSOME;

AMPHETAMINE; AMPHETAMINES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUBSTRATE SPECIFICITY; SYNAPTIC TRANSMISSION; XENOPUS LAEVIS;

RATTUS;

EID: 43549094952     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05272.x     Document Type: Article

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