Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: Evidence for enzymatic activity

Neuropsychopharmacology

Volumn 39, Issue 6, 2014, Pages 1538-1546

  Zlebnik, Natalie E ^a,b   Brimijoin, Stephen ^c   Gao, Yang ^c   Saykao, Amy T ^a   Parks, Robin J ^d   Carroll, Marilyn E ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

adenoviral vector; butyrylcholinesterase; cocaine hydrolase; gene therapy; methamphetamine; self administration

Indexed keywords

ADENOVIRUS VECTOR; COCAINE; COCAINE HYDROLASE; HYDROLASE; ISO OMPA; METHAMPHETAMINE; UNCLASSIFIED DRUG; CENTRAL STIMULANT AGENT; CHOLINESTERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; COCAINE BLOOD LEVEL; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG DEPENDENCE TREATMENT; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ADENOVIRIDAE; ANIMAL; BLOOD; COCAINE-RELATED DISORDERS; DRUG ABUSE; DRUG EFFECTS; DRUG SELF ADMINISTRATION; ENZYMOLOGY; GENE THERAPY; GENE VECTOR; GENETICS; INSTRUMENTAL CONDITIONING; METABOLISM; PHYSIOLOGY; THERAPY; TIME; WISTAR RAT;

ADENOVIRIDAE; AMPHETAMINE-RELATED DISORDERS; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; CHOLINESTERASE INHIBITORS; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; FEMALE; GENETIC THERAPY; GENETIC VECTORS; HYDROLASES; METHAMPHETAMINE; RATS; RATS, WISTAR; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; TETRAISOPROPYLPYROPHOSPHAMIDE; TIME FACTORS;

EID: 84900829023     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2014.3     Document Type: Article

References (35)

1. Anker JJ, Baron TR, Zlebnik NE, Carroll ME (2012a). Escalation of methamphetamine self-administration in adolescent and adult rats. Drug Alcohol Depend 124: 149-153.
2. Anker JJ, Brimijoin S, Gao Y, Geng L, Zlebnik NE, Parks RJ et al (2012b). Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months. Biol Psychiatry 71: 700-705.
3. Anker JJ, Carroll ME (2011). Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones. Curr Topics Behav Neurosci 8: 73-96.
4. Austin L, Berry WK (1953). Two selective inhibitors of cholinesterase. Biochem J 54: 695-700.
5. Berridge CW (2006). Neural substrates of psychostimulantinduced arousal. Neuropsychopharmacology 31: 2332-2340.
6. Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R et al (2008). A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 33: 2715-2725.
7. Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ et al (2013). Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. Chem Biol Interact 203: 212-216.
8. Brimijoin S, Shen ML, Sun H (2002). Radiometric solventpartitioning assay for screening cocaine hydrolases and measuring cocaine levels in milligram tissue samples. Anal Biochem 309: 200-205. (Pubitemid 35387310)
9. Carroll ME, Anker JJ (2010). Sex differences and ovarian hormones in animal models of drug dependence. Horm Behav 58: 44-56.
10. Carroll ME, Boe IN (1982). Increased intravenous drug selfadministration during deprivation of other reinforcers. Pharmacol Biochem Behav 17: 563-567. (Pubitemid 12037673)
11. Carroll ME, Gao Y, Brimijoin S, Anker JJ (2011). Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats. Psychopharmacology (Berl) 213: 817-829.
12. Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X et al (2012). Combined cocaine hydrolase gene transfer and anticocaine vaccine synergistically block cocaine-induced locomotion. PLoS One 7: e43536.
13. Crumb WJ Jr., Clarkson CW (1992). Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes. J Pharmacol Exp Ther 261: 910-917.
14. Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, Brimijoin S (2005). Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Mol Pharmacol 67: 204-211. (Pubitemid 40069980)
15. Gao Y, Brimijoin S (2004). An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J Pharmacol Exp Ther 310 1046-1052. (Pubitemid 39108926)
16. Gao Y, Brimijoin S (2006). Viral transduction of cocaine hydrolase in brain reward centers. Cell Mol Neurobiol 26: 357-363.
17. Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S (2010). The concept of pharmacologic interception as a treatment for drug abuse. Chem Biol Interact 187: 421-424.
18. Geng L, Gao Y, Chen X, Hou S, Zhan CG, Radic Z et al (2013). Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity. PLoS One 8: e67446.
19. Grubic Z, Sket D, Brzin M (1988). Iso-OMPA-induced potentiation of soman toxicity in rat correlates with the inhibition of plasma carboxylesterases. Arch Toxicol 62: 398-399. (Pubitemid 19013838)
20. Inaba T (1989). Cocaine: pharmacokinetics and biotransformation in man. Can J Physiol Pharmacol 67: 1154-1157. (Pubitemid 20002378)
21. Johanson CE, Fischman MW (1989). The pharmacology of cocaine related to its abuse. Pharmacol Rev 41: 3-52. (Pubitemid 19247826)
22. Kalow W(2004). Human pharmacogenomics: the development of a science. Hum Genomics 1: 375-380.
23. Mesulam M (2003). Butyrylcholinesterase in the normal and Alzheimer brain. In: Giacobini E (ed) Butyrylcholinesterase, Its Function and Inhibitors. Martin Dunitz: New York, pp 29-37.
24. Murthy V, Gao Y, Geng L, Lebrasseur N, White T, Brimijoin S (2013). Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice. J Mol Neurosci (2013): PMID: 24085526 (doi:10.1007/s12031-013-0130-5).
25. National Research Council (2011). Guide for the Care and Use of Animals. 8th edn. The National Academies Press: Washington, DC.
26. Pan Y, Gao D, Yang W, Cho H, Yang G, Tai HH et al (2005). Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc Natl Acad Sci USA 102: 16656-16661. (Pubitemid 41688832)
27. Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, Graham FL (1996). A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA 93: 13565-13570. (Pubitemid 26424159)
28. Seiden LS, Sabol KE, Ricaurte GA (1993). Amphetamine: effects on catecholamine systems and behavior. Annu Rev Pharmacol Toxicol 33: 639-677. (Pubitemid 23116021)
29. Soliday FK, Conley YP, Henker R (2010). Pseudocholinesterase deficiency: a comprehensive review of genetic, acquired, and drug influences. Aana J 78: 313-320.
30. Sun H, Pang YP, Lockridge O, Brimijoin S (2002). Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol Pharmacol 62: 220-224. (Pubitemid 34804100)
31. Tucker GT, Lennard MS, Ellis SW, Woods HF, Cho AK, Lin LY et al (1994). The demethylenation of methylenedioxymethamphetamine ('ecstasy') by debrisoquine hydroxylase (CYP2D6). Biochem Pharmacol 47: 1151-1156.
32. Weber A, Butterweck H, Mais-Paul U, Teschner W, Lei L, Muchitsch EM et al (2011). Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use. Vox Sang 100: 285-297.
33. Xue L, Hou S, Yang W, Fang L, Zheng F, Zhan CG (2013). Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine. Chem Biol Interact 203: 57-62.
34. Zheng F, Yang W, Ko MC, Liu J, Cho H, Gao D et al (2008). Most efficient cocaine hydrolase designed by virtual screening of transition states. J Am Chem Soc 130: 12148-12155.
35. Zlebnik NE, Anker JJ, Gliddon LA, Carroll ME (2010). Reduction of extinction and reinstatement of cocaine seeking by wheel running in female rats. Psychopharmacology 209: 113-125.