메뉴 건너뛰기




Volumn 8, Issue SUPPL. 1, 2014, Pages 118-127

Gold nanoparticles interfere with sperm functionality by membrane adsorption without penetration

Author keywords

Cell membrane; Fertility; Gold colloids; Ligand effect; Nanogold; Spermatozoa; Toxicity

Indexed keywords

GOLD NANOPARTICLE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SURFACTANT; GOLD; METAL NANOPARTICLE;

EID: 84900817689     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2013.859321     Document Type: Article
Times cited : (61)

References (60)
  • 1
    • 78650910257 scopus 로고    scopus 로고
    • Redox regulation od human sperm function: From the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line
    • Aitken RJ, Curry BJ. 2011. Redox regulation od human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line. Antioxid Redox Signal 14: 367-81.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 367-381
    • Aitken, R.J.1    Curry, B.J.2
  • 2
    • 84869467151 scopus 로고    scopus 로고
    • Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols
    • Aitken RJ, Gibb Z, Mitchell LA, Lambourne SR, Connaughton HS, De Iuliis GN. 2012. Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols. Biol Reprod 87: 1-11.
    • (2012) Biol Reprod , vol.87 , pp. 1-11
    • Aitken, R.J.1    Gibb, Z.2    Mitchell, L.A.3    Lambourne, S.R.4    Connaughton, H.S.5    De Iuliis, G.N.6
  • 3
    • 0032912824 scopus 로고    scopus 로고
    • Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: Modification of the body distribution after suspension in surfactant solutions and in oil vehicles
    • Araujo L, Sheppard M, Lobenberg R, Kreuter J. 1999. Uptake of PMMA nanoparticles from the gastrointestinal tract after oral administration to rats: modification of the body distribution after suspension in surfactant solutions and in oil vehicles. Int J Pharm 176: 209-24.
    • (1999) Int J Pharm , vol.176 , pp. 209-224
    • Araujo, L.1    Sheppard, M.2    Lobenberg, R.3    Kreuter, J.4
  • 4
    • 84861138981 scopus 로고    scopus 로고
    • Impact of spacer and strand length on oligonucleotide conjugation to the surface of ligand-free laser-generated gold nanoparticles
    • Barchanski A, Hashimoto N, Petersen S, Sajti CL, Barcikowski S. 2012. Impact of spacer and strand length on oligonucleotide conjugation to the surface of ligand-free laser-generated gold nanoparticles. Bioconjug Chem 23: 908-15.
    • (2012) Bioconjug Chem , vol.23 , pp. 908-915
    • Barchanski, A.1    Hashimoto, N.2    Petersen, S.3    Sajti, C.L.4    Barcikowski, S.5
  • 5
    • 84873923570 scopus 로고    scopus 로고
    • Advanced nanoparticle generation and excitation by lasers in liquids
    • Barcikowski S, Compagnini G. 2013. Advanced nanoparticle generation and excitation by lasers in liquids. Phys Chem Chem Phys 15: 3022-6.
    • (2013) Phys Chem Chem Phys , vol.15 , pp. 3022-3026
    • Barcikowski, S.1    Compagnini, G.2
  • 6
    • 34548236504 scopus 로고    scopus 로고
    • Generation of nanoparticle colloids by picosecond and femtosecond laser ablations in liquid flow
    • Article ID 083113
    • Barcikowski S, Menendez-Manjon A, Chichkov B, Brikas M, Raciukaitis G. 2007. Generation of nanoparticle colloids by picosecond and femtosecond laser ablations in liquid flow. Appl Phys Lett 91: Article ID 083113.
    • (2007) Appl Phys Lett , vol.91
    • Barcikowski, S.1    Menendez-Manjon, A.2    Chichkov, B.3    Brikas, M.4    Raciukaitis, G.5
  • 8
    • 27944489615 scopus 로고    scopus 로고
    • In vitro cytotoxicity of nanoparticles in mammalian germline stem cells
    • Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. 2005. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88: 412-9.
    • (2005) Toxicol Sci , vol.88 , pp. 412-419
    • Braydich-Stolle, L.1    Hussain, S.2    Schlager, J.J.3    Hofmann, M.C.4
  • 10
    • 80052989969 scopus 로고    scopus 로고
    • Characterization of flagellar cysteinerich sperm proteins involved in motility, by the combination of cellular fractionation, fluorescence detection, and mass spectrometry analysis
    • Cabrillana ME, Monclus MA, Saez Lancellotti TE, Boarelli PV, Clementi MA, Vincenti AE, et al. 2011. Characterization of flagellar cysteinerich sperm proteins involved in motility, by the combination of cellular fractionation, fluorescence detection, and mass spectrometry analysis. Cytoskeleton (Hoboken) 68: 491-500.
    • (2011) Cytoskeleton (Hoboken) , vol.68 , pp. 491-500
    • Cabrillana, M.E.1    Monclus, M.A.2    Saez Lancellotti, T.E.3    Boarelli, P.V.4    Clementi, M.A.5    Vincenti, A.E.6
  • 11
  • 12
    • 70349984818 scopus 로고    scopus 로고
    • Assessment of the in vivo toxicity of gold nanoparticles
    • Chen YS, Hung YC, Liau I, Huang GS. 2009b. Assessment of the in vivo toxicity of gold nanoparticles. Nanoscale Res Lett 4: 858-64.
    • (2009) Nanoscale Res Lett , vol.4 , pp. 858-864
    • Chen, Y.S.1    Hung, Y.C.2    Liau, I.3    Huang, G.S.4
  • 13
    • 33646397592 scopus 로고    scopus 로고
    • Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    • Chithrani BD, Ghazani AA, Chan WCW. 2006. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Letters 6: 662-8.
    • (2006) Nano Letters , vol.6 , pp. 662-668
    • Chithrani, B.D.1    Ghazani, A.A.2    Chan, W.C.W.3
  • 14
    • 62249098384 scopus 로고    scopus 로고
    • Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
    • Cho WS, Cho M, Jeong J, Choi M, Cho HY, Han BS, et al. 2009. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 236: 16-24.
    • (2009) Toxicol Appl Pharmacol , vol.236 , pp. 16-24
    • Cho, W.S.1    Cho, M.2    Jeong, J.3    Choi, M.4    Cho, H.Y.5    Han, B.S.6
  • 15
    • 77955008759 scopus 로고    scopus 로고
    • Surfacepotential- regulated transmembrane and cytotoxicity of chitosan/gold hybrid nanospheres
    • Ding Y, Bian XC, Yao W, Li RT, Ding D, Hu Y, et al. 2010. Surfacepotential- regulated transmembrane and cytotoxicity of chitosan/gold hybrid nanospheres. ACS Appl Mater Interfaces 2: 1456-65.
    • (2010) ACS Appl Mater Interfaces , vol.2 , pp. 1456-1465
    • Ding, Y.1    Bian, X.C.2    Yao, W.3    Li, R.T.4    Ding, D.5    Hu, Y.6
  • 16
    • 80054710886 scopus 로고    scopus 로고
    • Comparison of nanoparticle-mediated transfection methods for DNA expression plasmids: Efficiency and cytotoxicity
    • Duran MC, Willenbrock S, Barchanski A, Muller JMV, Maiolini A, Soller JT, et al. 2011. Comparison of nanoparticle-mediated transfection methods for DNA expression plasmids: efficiency and cytotoxicity. J Nanobiotechnol 9: 47.
    • (2011) J Nanobiotechnol , vol.9 , pp. 47
    • Duran, M.C.1    Willenbrock, S.2    Barchanski, A.3    Jmv, M.4    Maiolini, A.5    Soller, J.T.6
  • 17
    • 84857622034 scopus 로고    scopus 로고
    • Gold nanoparticles in biomedical applications: Recent advances and perspectives
    • Dykman L, Khlebtsov N. 2012. Gold nanoparticles in biomedical applications: recent advances and perspectives. Chem Soc Rev 41: 2256-82.
    • (2012) Chem Soc Rev , vol.41 , pp. 2256-2282
    • Dykman, L.1    Khlebtsov, N.2
  • 18
    • 0344505599 scopus 로고
    • In vitro maturation, fertilization and culture to blastocysts of bovine oocytes in protein-free media
    • Eckert J, Niemann H. 1995. In vitro maturation, fertilization and culture to blastocysts of bovine oocytes in protein-free media. Theriogenology 43: 1211-25.
    • (1995) Theriogenology , vol.43 , pp. 1211-1225
    • Eckert, J.1    Niemann, H.2
  • 20
    • 84871627448 scopus 로고    scopus 로고
    • Dynamic regulation of sperm interactions with the zona pellucida prior to and after fertilisation
    • Gadella B. 2013. Dynamic regulation of sperm interactions with the zona pellucida prior to and after fertilisation. Reprod Fertil Dev 1: 26-37.
    • (2013) Reprod Fertil Dev , vol.1 , pp. 26-37
    • Gadella, B.1
  • 21
    • 22144477899 scopus 로고    scopus 로고
    • Mechanics of receptor-mediated endocytosis
    • Gao H, Shi W, Freund LB. 2005. Mechanics of receptor-mediated endocytosis. Proc Natl Acad Sci U S A 102: 9469-74.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9469-9474
    • Gao, H.1    Shi, W.2    Freund, L.B.3
  • 22
    • 67349174323 scopus 로고    scopus 로고
    • The effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytes
    • Gopalan R, Osman I, Amani A, De Matas M, Anderson D. 2009. The effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytes. Nanotoxicology 3: 33-9.
    • (2009) Nanotoxicology , vol.3 , pp. 33-39
    • Gopalan, R.1    Osman, I.2    Amani, A.3    De Matas, M.4    Anderson, D.5
  • 23
    • 0002950423 scopus 로고
    • The morphology of boar spermatozoa
    • Hancock JL. 1957. The morphology of boar spermatozoa. J R Microsc Soc 76: 84-97.
    • (1957) J R Microsc Soc , vol.76 , pp. 84-97
    • Hancock, J.L.1
  • 24
    • 78649869690 scopus 로고    scopus 로고
    • Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone
    • Hirota M, Motoyama A, Suzuki M, Yanagi M, Kitagaki M, Kouzuki H, et al. 2010. Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone. J Toxicol Sci 35: 871-9.
    • (2010) J Toxicol Sci , vol.35 , pp. 871-879
    • Hirota, M.1    Motoyama, A.2    Suzuki, M.3    Yanagi, M.4    Kitagaki, M.5    Kouzuki, H.6
  • 25
    • 33244457595 scopus 로고    scopus 로고
    • Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods
    • Huang XH, El-Sayed IH, Qian W, El-Sayed MA. 2006. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128: 2115-20.
    • (2006) J Am Chem Soc , vol.128 , pp. 2115-2120
    • Huang, X.H.1    El-Sayed, I.H.2    Qian, W.3    El-Sayed, M.A.4
  • 26
    • 67649863481 scopus 로고    scopus 로고
    • The spermostatic and microbicidal actions of quinones and maleimides: Toward a dual-purpose contraceptive agent
    • Hughes LM, Griffith R, Carey A, Butler T, Donne SW, Beagley KW, Aitken RJ. 2009. The spermostatic and microbicidal actions of quinones and maleimides: toward a dual-purpose contraceptive agent. Mol Pharmacol 76: 113-24.
    • (2009) Mol Pharmacol , vol.76 , pp. 113-124
    • Hughes, L.M.1    Griffith, R.2    Carey, A.3    Butler, T.4    Donne, S.W.5    Beagley, K.W.6    Aitken, R.J.7
  • 27
    • 84876579991 scopus 로고    scopus 로고
    • Polymer-coated nanoparticles interacting with proteins and cells: Focusing on the sign of the net charge
    • Huhn D, Kantner K, Geidel C, Brandholt S, De Cock I, Soenen SJH, et al. 2013. Polymer-coated nanoparticles interacting with proteins and cells: focusing on the sign of the net charge. ACS Nano 7: 3253-63.
    • (2013) ACS Nano , vol.7 , pp. 3253-3263
    • Huhn, D.1    Kantner, K.2    Geidel, C.3    Brandholt, S.4    De Cock, I.5    Soenen, S.J.H.6
  • 28
    • 84866022677 scopus 로고    scopus 로고
    • Nanoparticle formation in a cavitation bubble after pulsed laser ablation in liquid studied with high time resolution small angle x-ray scattering
    • Article ID 103104
    • Ibrahimkutty S, Wagener P, Menzel A, Plech A, Barcikowski S. 2012. Nanoparticle formation in a cavitation bubble after pulsed laser ablation in liquid studied with high time resolution small angle x-ray scattering. Appl Phys Lett 101: Article ID 103104.
    • (2012) Appl Phys Lett , vol.101
    • Ibrahimkutty, S.1    Wagener, P.2    Menzel, A.3    Plech, A.4    Barcikowski, S.5
  • 29
    • 79955721224 scopus 로고    scopus 로고
    • Fluorescence manipulation by gold nanoparticles: From complete quenching to extensive enhancement
    • Kang KA, Wang JT, Jasinski JB, Achilefu S. 2011. Fluorescence manipulation by gold nanoparticles: from complete quenching to extensive enhancement. J Nanobiotechnol 9: 16.
    • (2011) J Nanobiotechnol , vol.9 , pp. 16
    • Kang, K.A.1    Wang, J.T.2    Jasinski, J.B.3    Achilefu, S.4
  • 30
    • 29544433253 scopus 로고    scopus 로고
    • Toxicity and tissue distribution of magnetic nanoparticles in mice
    • Kim JS, Yoon TJ, Kim BG, Park SJ, Kim HW, Lee KH, et al. 2006. Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 89: 338-47.
    • (2006) Toxicol Sci , vol.89 , pp. 338-347
    • Kim, J.S.1    Yoon, T.J.2    Kim, B.G.3    Park, S.J.4    Kim, H.W.5    Lee, K.H.6
  • 31
    • 58149380723 scopus 로고    scopus 로고
    • Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo
    • Kues WA, Sudheer S, Herrmann D, Carnwath JW, Havlicek V, Besenfelder U, et al. 2008. Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo. Proc Natl Acad Sci USA 105: 19768-73.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19768-19773
    • Kues, W.A.1    Sudheer, S.2    Herrmann, D.3    Carnwath, J.W.4    Havlicek, V.5    Besenfelder, U.6
  • 34
    • 38849111818 scopus 로고    scopus 로고
    • Cytotoxicity of nanoparticles
    • Lewinski N, Colvin V, Drezek R. 2008. Cytotoxicity of nanoparticles. Small 4: 26-49.
    • (2008) Small , vol.4 , pp. 26-49
    • Lewinski, N.1    Colvin, V.2    Drezek, R.3
  • 35
    • 76549245335 scopus 로고
    • Sulfhydryl groups in relation to the metabolism and motility of human spermatozoa
    • Macleod J. 1951. Sulfhydryl groups in relation to the metabolism and motility of human spermatozoa. J Gen Physiol 34: 705-14.
    • (1951) J Gen Physiol , vol.34 , pp. 705-714
    • Macleod, J.1
  • 36
  • 38
    • 36549043374 scopus 로고    scopus 로고
    • Loading magnetic nanoparticles into sperm cells does not affect their functionality
    • Makhluf SBD, Qasem R, Rubinstein S, Gedanken A, Breitbart H. 2006. Loading magnetic nanoparticles into sperm cells does not affect their functionality. Langmuir 22: 9480-2.
    • (2006) Langmuir , vol.22 , pp. 9480-9482
    • Makhluf, S.B.D.1    Qasem, R.2    Rubinstein, S.3    Gedanken, A.4    Breitbart, H.5
  • 40
    • 67649491055 scopus 로고    scopus 로고
    • Understanding biophysicochemical interactions at the nano-bio interface
    • Nel AE, Madler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, et al. 2009. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8: 543-57.
    • (2009) Nat Mater , vol.8 , pp. 543-557
    • Nel, A.E.1    Madler, L.2    Velegol, D.3    Xia, T.4    Emv, H.5    Somasundaran, P.6
  • 41
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles
    • Oberdörster G, Oberdorster E, Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113: 823-39.
    • (2005) Environ Health Perspect , vol.113 , pp. 823-839
    • Oberdörster, G.1    Oberdorster, E.2    Oberdorster, J.3
  • 43
    • 84875268209 scopus 로고    scopus 로고
    • High-sensitivity real-time analysis of nanoparticle toxicity in green fluorescent protein-expressing zebrafish
    • Pan Y, Leifert A, Graf M, Schiefer F, Thoroe-Boveleth S, Broda J, et al. 2013. High-sensitivity real-time analysis of nanoparticle toxicity in green fluorescent protein-expressing zebrafish. Small 9: 863-9.
    • (2013) Small , vol.9 , pp. 863-869
    • Pan, Y.1    Leifert, A.2    Graf, M.3    Schiefer, F.4    Thoroe-Boveleth, S.5    Broda, J.6
  • 44
    • 70349470888 scopus 로고    scopus 로고
    • Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage
    • Pan Y, Leifert A, Ruau D, Neuss S, Bornemann J, Schmid G, et al. 2009. Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. Small 5: 2067-76.
    • (2009) Small , vol.5 , pp. 2067-2076
    • Pan, Y.1    Leifert, A.2    Ruau, D.3    Neuss, S.4    Bornemann, J.5    Schmid, G.6
  • 47
    • 84873886705 scopus 로고    scopus 로고
    • Size control of laser-fabricated surfactant-free gold nanoparticles with highly diluted electrolytes and their subsequent bioconjugation
    • Rehbock C, Merk V, Gamrad L, Streubel R, Barcikowski S. 2013. Size control of laser-fabricated surfactant-free gold nanoparticles with highly diluted electrolytes and their subsequent bioconjugation. Phys Chem Chem Phys 15: 3057-67.
    • (2013) Phys Chem Chem Phys , vol.15 , pp. 3057-3067
    • Rehbock, C.1    Merk, V.2    Gamrad, L.3    Streubel, R.4    Barcikowski, S.5
  • 48
    • 84862011525 scopus 로고    scopus 로고
    • Woodrow Wilson Database 2013 [Accessed Oct 13, 2013]
    • Rejeski D. 2005. The Project on Emerging Nanotechnologies [Online].Woodrow Wilson Database 2013. Available: http://www.R-project.org/ [Accessed Oct 13, 2013].
    • (2005) The Project on Emerging Nanotechnologies
    • Rejeski, D.1
  • 50
    • 25744466201 scopus 로고
    • Grundstruktur der Spermienzelle und Biochemie des Spermas
    • Busch W, Löhle K, PeterW, eds. Stuttgart: Gustav Fischer Verlag Jena
    • Schülke B. 1991. Grundstruktur der Spermienzelle und Biochemie des Spermas. In BuschW, Löhle K, PeterW, eds. Künstliche Besamung bei Nutztieren. Stuttgart: Gustav Fischer Verlag Jena, 209-48.
    • (1991) Künstliche Besamung Bei Nutztieren , pp. 209-248
    • Schülke, B.1
  • 51
    • 28044446787 scopus 로고    scopus 로고
    • Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview
    • Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M. 2005. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21: 10644-54.
    • (2005) Langmuir , vol.21 , pp. 10644-10654
    • Shukla, R.1    Bansal, V.2    Chaudhary, M.3    Basu, A.4    Bhonde, R.R.5    Sastry, M.6
  • 52
    • 67349133554 scopus 로고    scopus 로고
    • NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials
    • Singh N, Manshian B, Jenkins GJS, Griffiths SM, Williams PM, Maffeis TGG, et al. 2009. NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30: 3891-914.
    • (2009) Biomaterials , vol.30 , pp. 3891-3914
    • Singh, N.1    Manshian, B.2    Gjs, J.3    Griffiths, S.M.4    Williams, P.M.5    Tgg, M.6
  • 53
    • 77951200279 scopus 로고    scopus 로고
    • Nonendosomal cellular uptake of ligand-free, positively charged gold nanoparticles
    • Taylor U, Klein S, Petersen S, Kues W, Barcikowski S, Rath D. 2010. Nonendosomal cellular uptake of ligand-free, positively charged gold nanoparticles. Cytometry A 77A: 439-46.
    • (2010) Cytometry A , vol.77 A , pp. 439-446
    • Taylor, U.1    Klein, S.2    Petersen, S.3    Kues, W.4    Barcikowski, S.5    Rath, D.6
  • 54
    • 2442660623 scopus 로고    scopus 로고
    • Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains
    • Tkachenko AG, Xie H, Liu YL, Coleman D, Ryan J, Glomm WR, et al. 2004. Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains. Bioconjug Chem 15: 482-90.
    • (2004) Bioconjug Chem , vol.15 , pp. 482-490
    • Tkachenko, A.G.1    Xie, H.2    Liu, Y.L.3    Coleman, D.4    Ryan, J.5    Glomm, W.R.6
  • 57
    • 51149203926 scopus 로고
    • Feret's statistical diameter as a measure of particle size
    • Walton WH. 1948. Feret's statistical diameter as a measure of particle size. Nature 162: 329-30.
    • (1948) Nature , vol.162 , pp. 329-330
    • Walton, W.H.1
  • 58
    • 57849127136 scopus 로고    scopus 로고
    • Effect of gold nanoparticles on spermatozoa: The first world report
    • Wiwanitkit V, Sereemaspun A, Rojanathanes R. 2009. Effect of gold nanoparticles on spermatozoa: the first world report. Fertil Steril 91: e7-8.
    • (2009) Fertil Steril , vol.91
    • Wiwanitkit, V.1    Sereemaspun, A.2    Rojanathanes, R.3
  • 59
    • 0035024267 scopus 로고    scopus 로고
    • Effects of culture system and protein supplementation on mRNA expression in pre-implantation bovine embryos
    • Wrenzycki C, Herrmann D, Keskintepe L, Martins AJR, Sirisathien S, Brackett B, Niemann H. 2001. Effects of culture system and protein supplementation on mRNA expression in pre-implantation bovine embryos. Hum Reprod 16: 893-901.
    • (2001) Hum Reprod , vol.16 , pp. 893-901
    • Wrenzycki, C.1    Herrmann, D.2    Keskintepe, L.3    Ajr, M.4    Sirisathien, S.5    Brackett, B.6    Niemann, H.7
  • 60
    • 79551678542 scopus 로고    scopus 로고
    • Toxicologic effects of gold nanoparticles in vivo by different administration routes
    • Zhang XD, Wu HY, Wu D, Wang YY, Chang JH, Zhai ZB, et al. 2010. Toxicologic effects of gold nanoparticles in vivo by different administration routes. Int J Nanomed 5: 771-81.
    • (2010) Int J Nanomed , vol.5 , pp. 771-781
    • Zhang, X.D.1    Wu, H.Y.2    Wu, D.3    Wang, Y.Y.4    Chang, J.H.5    Zhai, Z.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.