Differential hERG ion channel activity of ultrasmall gold nanoparticles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8004-8009

  Leifert, Annika ^a   Pan, Yu ^a   Kinkeldey, Anne ^a   Schiefer, Frank ^a   Setzler, Julia ^b   Scheel, Olaf ^c   Lichtenbeld, Hera ^d   Schmid, Günter ^e   Wenzel, Wolfgang ^b   Jahnen Dechent, Willi ^a   Simon, Ulrich ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c Cytocentrics Bioscience GmbH   (Germany)

^d HLConsulting   (Netherlands)

^e UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Complementarity; Gold cluster; Nanotoxicology; Shape

Indexed keywords

GOLD NANOPARTICLE; POTASSIUM CHANNEL HERG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

COMPLEMENTARITY; GOLD CLUSTER; NANOTOXICOLOGY; SHAPE;

ANIMALS; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; GOLD; HEK293 CELLS; HUMANS; MALE; METAL NANOPARTICLES; MICE; MICE, INBRED C57BL; NANOTECHNOLOGY; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; TEMPERATURE;

EID: 84877866112     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220143110     Document Type: Article

References (37)

1. Tiwari PM, Vig K, Dennis VA, Singh SR (2011) Functionalized gold nanoparticles and their biomedical applications. Nanomaterials 1(1):31-63.
2. Daniel M-C, Astruc D (2004) Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104(1):293-346.
3. Giljohann DA, Mirkin CA (2009) Drivers of biodiagnostic development. Nature 462(7272): 461-464.
4. Kim B, et al. (2010) Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol 5(6):465-472.
5. Popovtzer R, et al. (2008) Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett 8(12):4593-4596.
6. Cutler JI, Auyeung E, Mirkin CA (2012) Spherical nucleic acids. J Am Chem Soc 134(3): 1376-1391.
7. Pan Y, et al. (2007) Size-dependent cytotoxicity of gold nanoparticles. Small 3(11):1941-1949. (Pubitemid 350099867)
8. Pan Y, et al. (2009) Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. Small 5(18):2067-2076.
9. Pan Y, et al. (2013) High sensitivity real-time analysis of nanoparticles toxicity in green fluorescent protein expressing zebrafish. Small 9(6):863-869, 10.1002/smll.2012.
10. Schmid G, Klein N, Korste L, Kreibig U, Schönauer D (1988) Large transition metal clusters-VI. Ligand exchange reactions on Au55(PPh3)12Cl6-The formation of a water soluble Au55 cluster. Polyhedron 7:605-608.
11. Krug HF, Wick P (2011) Nanotoxicology: An interdisciplinary challenge. Angew Chem Int Ed Engl 50(6):1260-1278.
12. Sanguinetti MC, Tristani-Firouzi M (2006) hERG potassium channels and cardiac arrhythmia. Nature 440(7083):463-469.
13. Fermini B, Fossa AA (2003) The impact of drug-induced QT interval prolongation on drug discovery and development. Nat Rev Drug Discov 2(6):439-447. (Pubitemid 37361725)
14. Food and Drug Administration (2005) ICH S7B Guideline of FDA (Food and Drug Administration, Rockville, MD).
15. Mitcheson JS (2003) Drug binding to HERG channels: Evidence for a 'non-aromatic' binding site for fluvoxamine. Br J Pharmacol 139(5):883-884. (Pubitemid 36877386)
16. Kirchner C, et al. (2005) Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 5(2):331-338. (Pubitemid 40308295)
17. Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC (2000) A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 97(22):12329-12333.
18. Lees-Miller JP, Duan Y, Teng GQ, Duff HJ (2000) Molecular determinant of highaffinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites. Mol Pharmacol 57(2):367-374. (Pubitemid 30084514)
19. Myokai T, Ryu S, Shimizu H, Oiki S (2008) Topological mapping of the asymmetric drug binding to the human ether-à-go-go-related gene product (HERG) potassium channel by use of tandem dimers. Mol Pharmacol 73(6):1643-1651. (Pubitemid 351724353)
20. Nanoprobes (2009) The first Gold Nanoparticle X-ray Contrast Agent for in vivo use. Available at www.nanoprobes.com/instructions/Inf1102.html.
21. Schmid G (1985) Developments in transition metal cluster chemistry-the way to large clusters. Struct Bond 62:51-85.
22. Wales DJ, et al. The Cambridge Cluster Database. Available at http://www-wales.ch. cam.ac.uk/CCD.html.
23. Long SB, Campbell EB, Mackinnon R (2005) Crystal structure of a mammalian voltagedependent Shaker family K+ channel. Science 309(5736):897-903. (Pubitemid 41099919)
24. Stary A, et al. (2010) Toward a consensus model of the HERG potassium channel. ChemMedChem 5(3):455-467.
25. Staudacher I, et al. (2011) hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. Naunyn Schmiedebergs Arch Pharmacol 383(2):119-139.
26. Casals E, Pfaller T, Duschl A, Oostingh GJ, Puntes V (2010) Time evolution of the nanoparticle protein corona. ACS Nano 4(7):3623-3632.
27. Lacerda SH, et al. (2010) Interaction of gold nanoparticles with common human blood proteins. ACS Nano 4(1):365-379.
28. Salama G, London B (2007) Mouse models of long QT syndrome. J Physiol 578(Pt 1): 43-53. (Pubitemid 44971109)
29. Antzelevitch C (2007) Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace 9(Suppl 4):iv4-iv15.
30. Joó F, et al. (1998) (Meta-sulfonatophenyl)diphenylphosphine, sodium salt and its complexes with rhodium(I), ruthenium(II), iridium(I). Inorg Synth 32:1-8.
31. Schmid G, et al. (1981) Au55[P(C6H5)3]12Cl6-ein Goldcluster ungewöhnlicher Größe [Au55[P(C6H5)3]12Cl6-A gold cluster of unusual size]. Chem Ber 114:3634-3642.
32. Negishi Y, et al. (2004) Magic-numbered Aun clusters protected by glutathione monolayers (n = 18, 21, 25, 28, 32, 39): Isolation and spectroscopic characterization. JACS 126:6518-6519. (Pubitemid 38697329)
33. Scheel O, Himmel H, Rascher-Eggstein G, Knott T (2011) Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-àgo-go related gene voltage-clamp data. Assay Drug Dev Technol 9(6):600-607.
34. Metropolis N, Rosenbluth AW, Rosenbluth MN, Teller AH, Teller E (1953) Equation of state calculations by fast computing machines. J Chem Phys 21:1087-1092.
35. Dolinsky TJ, et al. (2007) PDB2PQR: Expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res 35(Web Server issue):W522-W525.
36. Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA (2004) PDB2PQR: An automated pipeline for the setup, execution, and analysis of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res 32:W665-W667. (Pubitemid 38997419)
37. Ahlrichs R, Bär M, Häser M, Horn H, Kölmel C (1989) Electronic structure calculations on workstation computers: The program system Turbomole. Chem Phys Lett 162(3): 165-169.