Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H5N1

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2680-2684

  Yang, Jian ^a   Yang, Jing Xiang ^a,b,c   Zhang, Fang ^a,b   Chen, Gang ^a,b   Pan, Wei ^b   Yu, Rui ^a,b   Wu, Shuwen ^b   Tien, Po ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Entry inhibitor; HA2; Molecular modeling; Small molecular polyphenols; Synthesis

Indexed keywords

ANTIVIRUS AGENT; POLYPHENOL DERIVATIVE; SIALIDASE; SMALL MOLECULAR POLYPHENOL; UNCLASSIFIED DRUG; VIRUS HEMAGGLUTININ; MOLECULAR LIBRARY; POLYPHENOL; AMANTADINE; VIRUS FUSION INHIBITOR; ZANAMIVIR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFLUENZA A (H5N1); MOLECULAR MODEL; NONHUMAN; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; VIRUS ENTRY; VIRUS INHIBITION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; IC50; INFLUENZA A VIRUS (H5N1); MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS; DRUG MECHANISM; DRUG TARGETING; HEMAGGLUTINATION INHIBITION; HYDROGEN BOND; INFLUENZA VIRUS A H5N1; MDCK CELL LINE; MOLECULAR DOCKING; STEREOSPECIFICITY;

ANTIVIRAL AGENTS; DRUG DESIGN; INFLUENZA A VIRUS, H5N1 SUBTYPE; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; POLYPHENOLS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS INTERNALIZATION;

EID: 84900805665     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.057     Document Type: Article

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