Regulation of chondrocyte proliferation through GiT1-Rac1- mediated ERK1/2 pathway by PDGF

Cell Biology International

Volumn 38, Issue 6, 2014, Pages 695-701

  Xiao, Jin ^a   Chen, Xuqiong ^a   Xu, Lipeng ^a   Zhang, Ying ^a   Yin, Qingshui ^a   Wang, Fei ^a  

^a Liuhuaqiao Hospital   (China)

Author keywords

Chondrocyte; ERK1 2; GIT1; PDGF; Rac1

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE INTERACTING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; RAC1 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; AMINOQUINOLINE DERIVATIVE; CELL CYCLE PROTEIN; FLAVONOID; GIT1 PROTEIN, RAT; PHOSPHOPROTEIN; PLATELET-DERIVED GROWTH FACTOR A; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; FRACTURE; G1 PHASE CELL CYCLE CHECKPOINT; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; WOUND HEALING;

AMINOQUINOLINES; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; FLAVONOIDS; FRACTURES, BONE; G1 PHASE CELL CYCLE CHECKPOINTS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, SMALL INTERFERING; WOUND HEALING;

EID: 84900797357     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10241     Document Type: Article

References (28)

1. Adams CS, Shapiro IM (2002) The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis. Crit Rev Oral Biol Med 13: 465-73.
2. Appleton CT, Usmani SE, Mort JS, Beier F (2010) Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation. Lab Invest 90: 20-30.
3. Arrizabalaga O, Lacerda HM, Zubiaga AM, Zugaza JL (2012) Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation. J Biol Chem 287: 11878-90.
4. Barbero A, Palumberi V, Wagner B, Sader R, Grote MJ, Martin I (2005) Experimental and mathematical study of the influence of growth factors on the growth kinetics of adult human articular chondrocytes. J Cell Physiol 204: 830-8.
5. Bhanot H, Young AM, Overmeyer JH, Maltese WA (2010) Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6.Mol Cancer Res 8: 1358-74.
6. Bhavsar PJ, Vigorito E, Turner M, Ridley AJ (2009) Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. Exp Cell Res 315: 3345-58.
7. Chen Y, Ke J, Long X, Meng Q, Deng M, Fang W et al. (2012) Insulin-like growth factor-1 boosts the developing process of condylar hyperplasia by stimulating chondrocytes proliferation. Osteoarthritis Cartilage 20: 279-87.
8. Cheng B, Liu HW, Fu XB, Sun TZ, Sheng ZY (2007) Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats. J Dermatol Sci 45: 193-201.
9. Claing A, Perry SJ, Achiriloaie M, Walker JK, Albanesi JP, Lefkowitz RJ et al. (2000) Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proc Natl Acad Sci U S A 97: 1119-24.
10. Dorotka R, Windberger U, Macfelda K, Bindreiter U, Toma C, Nehrer S (2005) Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix. Biomaterials 26: 3617-29.
11. Einhorn TA (1998) The cell and molecular biology of fracture healing. Clin Orthop Relat Res (355 Suppl): S7-21.
12. Fitzgerald JB, Jin M, Chai DH, Siparsky P, Fanning P, Grodzinsky AJ (2008) Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants. J Biol Chem 283: 6735-43.
13. Fukuo K, Morimoto S, Kaji K, Koh E, Hironaka T, Morita R et al. (1989) Association of increased intracellular free Ca2p by platelet-derived growth factor with mitogenesis but not with proteoglycan synthesis in chondrocytes-effect of suramin. Cell Calcium 10: 29-35.
14. Hajdo-Milasinovic A, van der Kammen RA, Moneva Z, Collard JG (2009) Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. J Cell Sci 122: 2127-36.
15. Häuselmann SP, Rosc-Schlüter BI, Lorenz V, Plaisance I, Brink M, Pfister O et al. (2011) b1-Integrin is up-regulated via Rac1- dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response. Free Radic Biol Med 51: 609-18.
16. Jones NP, KatanM(2007) Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Biol 27: 5790-805.
17. Kim KN, Pie JE, Park JH, Park YH, Kim HW, Kim MK (2006) Retinoic acid and ascorbic acid act synergistically in inhibiting human breast cancer cell proliferation. J Nutr Biochem 17: 454-62.
18. Nakaya M, Tajima M, Kosako H, Nakaya T, Hashimoto A, Watari K et al. (2013) GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance. Nat Commun 4: 1532.
19. Raffetto JD, Vasquez R, Goodwin DG, Menzoian JO (2006) Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts. Vasc Endovascular Surg 40: 59-66.
20. Ren K, Liu F, Huang Y, Liang W, Cui W, Wang Q et al. (2012a) Periodic mechanical stress activates integrinb1-dependent Srcdependent PLCb1-independent Rac1 mitogenic signal in rat chondrocytes through ERK1/2. Cell Physiol Biochem 30: 827-42.
21. Ren Y, Yu L, Fan J, Rui Z, Hua Z, Zhang Z et al. (2012b) Phosphorylation of GIT1 tyrosine 321 is required for association with FAK at focal adhesions and for PDGFactivated migration of osteoblasts. Mol Cell Biochem 365: 109-18.
22. Rui Z, Li X, Fan J, Ren Y, Yuan Y, Hua Z et al. (2012) GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing. Int J Mol Med 30: 819-25.
23. Schmalzigaug R, Phee H, Davidson CE, Weiss A, Premont RT (2007) Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J Histochem Cytochem 55: 1039-48.
24. Schmidt MB, Chen EH, Lynch SE (2006) A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthritis Cartilage 14: 403-12.
25. Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR (2010) Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Res 70: 2064-74.
26. Wang G, Beier F (2005) Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J Bone Miner Res 20: 1022-31.
27. Wang JL, Chan RC, Cheng HH, Huang CJ, Lu YC, Chen IS et al. (2007) Short waves-induced enhancement of proliferation of human chondrocytes: involvement of extracellular signalregulated map-kinase (erk). Clin Exp Pharmacol Physiol 34: 581-5.
28. Yang D, Chen J, Jing Z, Jin D (2000) Platelet-derived growth factor (PDGF)-AA: a self-imposed cytokine in the proliferation of human fetal osteoblasts. Cytokine 12: 1271-4.