Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats

Journal of Dermatological Science

Volumn 45, Issue 3, 2007, Pages 193-201

  Cheng, Biao ^a   Liu, Hong Wei ^a   Fu, Xiao Bing ^b   Sun, Tong Zhu ^b   Sheng, Zhi Yong ^b  

^a Guangzhou Liuhuaqiao Hospital   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Diabetes; Extracellular signal regulated kinases; Platelet derived growth factor; Wound healing

Indexed keywords

CELL NUCLEUS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIZATION; GRANULATION TISSUE; HISTOLOGY; LABELING INDEX; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SKIN INJURY; SKINFOLD THICKNESS; TISSUE REPAIR; WOUND HEALING;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BLOOD GLUCOSE; DERMIS; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; WOUND HEALING; WOUNDS AND INJURIES;

EID: 33846903306     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2006.11.014     Document Type: Article

References (28)

1. Gao Z.Y., Sasaoka T., Fujimori T., et al. Deletion of the PDGF-beta gene affects key fibroblasts functions important for wound healing. J Biol Chem 280 10 (2005) 9375-9389
2. Heldin C.H., and Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79 4 (1999) 1283-1316
3. Mustoe T.A., Pierce G.F., Morishima C., and Deuel T.F. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J Clin Invest 87 2 (1991) 694-703
4. Martin P. Wound healing-aiming for perfect skin regeneration. Science 276 5309 (1997) 75-81
5. Robson M.C., Phillips L.G., Thomason A., Robson L.E., and Pierce G.F. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet 339 8784 (1992) 23-25
6. Cohen M.A., and Eaglstein W.H. Recombinant human platelet-derived growth factor gel speeds healing of acute full-thickness punch biopsy wounds. J Am Acad Dermatol 45 6 (2001) 862-875
7. Brown R.L., Breeden M.P., and Greenhalgh D.G. PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res 56 6 (1994) 562-570
8. Sprugel K.H., Greenhalgh D.G., Murray M.J., and Ross R. Platelet-derived growth factor and impaired wound healing. Prog Clin Biol Res 365 (1991) 327-340
9. Wieman T.J., Smiell J.M., and Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplemin) in patients with chronic neuropathic diabetic ulcers: a phase III randomized placebo-controled double-blind study. Diab Care 21 5 (1998) 822-827
10. Wieman T.J. Clinical efficacy of becaplemin (rhPDGF-BB) gel. Am J Surg 176 2A Suppl. (1998) 74S-79S
11. Heldin C.H., Ostman A., and Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1378 1 (1998) F79-F113
12. Widmann C., Gibson S., Jarpe M.B., and Johnson G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79 1 (1999) 143-180
13. Davis R.J. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268 20 (1993) 14533-14556
14. Yates S., and Rayner T.E. Transcription factor activation in response to cutaneous injury: role of AP-1 in reepithelialization. Wound Repair Regen 10 1 (2002) 5-15
15. Mahimainathan L., and Choudhury G.G. Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. J Biol Chem 279 15 (2004) 15258-15268
16. Doxey D.L., Nares S., Park B., Trieu C., Cutler C.W., and Iacopino A.M. Diabetes-induced impairment of macrophage cytokine release in a rat model: potential role of serum lipids. Life Sci 63 13 (1998) 1127-1136
17. Altavilla D., Saitta A., Cucinotta D., Galeano M., Deodato B., Colonna M., et al. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 50 3 (2001) 667-674
18. Hall P.A., Levison D.A., Woods A.L., Yu C.C., Kellock D.B., and Watkins J.A. Proliferation cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162 24 (1990) 285-294
19. Motiwale L., Ingle A.D., and Rao K.V.K. Mouse skin tumor promotion by sodium arsenate is associated with enhanced PCNA expression. Cancer Lett 223 1 (2005) 27-35
20. Pierce G.F., and Mustoe T.A. Pharmacological enhancement of wound healing. Annu Rev Med 46 (1995) 467-481
21. Kondo T., Ohshima T., Sato Y., Mayama T., and Eisenmenger W. Immunohistochemical study on the expression of c-fos and c-Jun in human skin wounds. Histochem J 32 8 (2000) 509-514
22. Clark R.A. Basics of cutaneous wound healing. J Dermatol Surg Oncol 19 8 (1993) 693-706
23. Wang X.T., Liu P.Y., and Tang J.B. PDGF gene therapy enhances expression of VEGF and bFGF genes and activates the NF-kappaB gene in signal pathways in ischemic flaps. Plast Reconstr Surg 117 1 (2006) 129-139
24. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81 2 (2001) 807-869
25. Raffetto J.D., Vasquez R., Goodwin D.G., and Menzoian J.O. Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts. Vasc Endovascular Surg 40 1 (2006) 59-66
26. Chang H.J., Park J.S., Kim M.H., Hong M.H., Kim K.M., Kim S.M., et al. Extracellular signal-regulated kinases and AP-1 mediate the up-regulation of vascular endothelial growth factor by PDGF in human vascular smooth muscle cells. Int J Oncol 28 1 (2006) 135-141
27. Pullar C.E., Grahn J.C., Liu W., and Isseroff R.R. Beta2-adrenergic receptor activation delays wound healing. FASEB J 20 1 (2006) 76-86
28. Chang L., and Karin M. Mammalian MAP kinase signaling cascades. Nature 410 6824 (2001) 37-40