The Indian spice turmeric delays and mitigates radiation-induced oral mucositis in patients undergoing treatment for head and neck cancer: An investigational study

Integrative Cancer Therapies

Volumn 13, Issue 3, 2014, Pages 201-210

  Rao, Suresh ^a   Dinkar, Chetana ^a   Vaishnav, Lalit Kumar ^a   Rao, Pratima ^b   Rai, Manoj Ponadka ^a   Fayad, Raja ^c   Baliga, Manjeshwar Shrinath ^d  

^a Mangalore Institute of Oncology   (India)

^b Century International Institute of Dental Sciences and Research Centre Poinachi   (India)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

^d FATHER MULLER MEDICAL COLLEGE   (India)

Author keywords

mucositis; povidone iodine; radiation; turmeric

Indexed keywords

CARBOPLATIN; MOUTHWASH; POVIDONE IODINE; TURMERIC; TOPICAL ANTIINFECTIVE AGENT;

ADULT; ARTICLE; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; CLINICAL ASSESSMENT TOOL; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; FEMALE; GARGLE; HEAD AND NECK CANCER; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ORAL MUCOSITIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIATION INDUCED ORAL MUCOSITIS; RADIATION THERAPY ONCOLOGY GROUP SYSTEM; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; WEIGHT CHANGE; ADVERSE EFFECTS; AGED; CHEMISTRY; COMPARATIVE STUDY; CURCUMA; HEAD AND NECK NEOPLASMS; PATHOLOGY; PROCEDURES; RADIATION INJURIES; STOMATITIS; TIME FACTOR;

ADULT; AGED; ANTI-INFECTIVE AGENTS, LOCAL; CARBOPLATIN; CHEMORADIOTHERAPY; CURCUMA; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MOUTHWASHES; POVIDONE-IODINE; RADIATION INJURIES; SINGLE-BLIND METHOD; STOMATITIS; TIME FACTORS;

EID: 84900796284     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735413503549     Document Type: Article

References (67)

1. Sonis ST, Elting LS, Keefe D, et al. Mucositis Study Section of the Multinational Association for Supportive Care in Cancer; International Society for Oral Oncology. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004 ; 100: 1995-2025
2. Khanal B, Baliga M, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg. 2010 ; 39: 1181-1185
3. Elting LS, Cooksley CD, Chambers MS, Garden AS. Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. Int J Radiat Oncol Biol Phys. 2007 ; 68: 1110-1120
4. Peterman A, Cella D, Glandon G, Dobrez D, Yount S. Mucositis in head and neck cancer: economic and quality-of-life outcomes. J Natl Cancer Inst Monogr. 2001 ; 29: 45-51
5. Rodríguez-Caballero A, Torres-Lagares D, Robles-García M, Pachón-Ibáñez J, González-Padilla D, Gutiérrez-Pérez JL. Cancer treatment-induced oral mucositis: a critical review. Int J Oral Maxillofac Surg. 2012 ; 41: 225-238
6. Biswal BM, Zakaria A, Ahmad NM. Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer. 2003 ; 11: 242-248
7. You WC, Hsieh CC, Huang JT. Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis. J Altern Complement Med. 2009 ; 15: 771-778
8. Maddocks-Jennings W, Wilkinson JM, Cavanagh HM, Shillington D. Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: a randomized, placebo controlled feasibility study. Eur J Oncol Nurs. 2009 ; 13: 87-93
9. Das D, Agarwal SK, Chandola HM. Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies. Ayu. 2011 ; 32: 196-199
10. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Complement Med. 2003 ; 9: 161-168
11. Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: biological actions and medicinal applications. Curr Sci. 2004 ; 87: 44-53
12. Calabrese V, Bates TE, Mancuso C, et al. Curcumin and the cellular stress response in free radical-related diseases. Mol Nutr Food Res. 2008 ; 52: 1062-1073
13. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 ; 15: 195-218
14. Azuine MA, Bhide SV. Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models. J Ethnopharmacol. 1994 ; 44: 211-217
15. Li N, Chen X, Han C, Chen J. Chemopreventive effect of tea and curcumin on DMBA-induced oral carcinogenesis in hamsters [in Chinese]. Wei Sheng Yan Jiu. 2002 ; 31: 354-357
16. Li N, Chen X, Liao J, et al. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA) -induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis. 2002 ; 23: 1307-1313
17. Manoharan S, Balakrishnan S, Menon VP, Alias LM, Reena AR. Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a] anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J. 2009 ; 50: 139-146
18. Zhang XY, Chen XF, Sun Z, Miao CC, Ge LH, Tian ZC. Chemopreventive effect of boswellic acid and curcumin on 7,12-dimethyl benzanthracene-induced hamster cheek pouch carcinogenesis [in Chinese]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 ; 46: 678-683
19. Ip SW, Wu SY, Yu CC, et al. Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways. Cell Biochem Funct. 2011 ; 29: 641-650
20. Sharma C, Kaur J, Shishodia S, Aggarwal BB, Ralhan R. Curcumin down regulates smokeless tobacco-induced NF-κB activation and COX-2 expression in human oral premalignant and cancer cells. Toxicology. 2006 ; 228: 1-15
21. Atsumi T, Tonosaki K, Fujisawa S. Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin. Arch Oral Biol. 2006 ; 51: 913-921
22. Dujic J, Kippenberger S, Ramirez-Bosca A, et al. Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. Int J Cancer. 2009 ; 124: 1422-1428
23. Liao S, Xia J, Chen Z, et al. Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways. J Cell Biochem. 2011 ; 112: 1055-1065
24. Antunes LM, Darin JD, Bianchi Nde L. Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. Pharmacol Res. 2001 ; 43: 145-150
25. Ilbey YO, Ozbek E, Cekmen M, Simsek A, Otunctemur A, Somay A. Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod. 2009 ; 24: 1717-1725
26. Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. J Agric Food Chem. 2007 ; 55: 10150-10155
27. Alaikov T, Konstantinov SM, Tzanova T, Dinev K, Topashka-Ancheva M, Berger MR. Antineoplastic and anticlastogenic properties of curcumin. Ann N Y Acad Sci. 2007 ; 1095: 355-370
28. Chan WH, Wu CC, Yu JS. Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. J Cell Biochem. 2003 ; 90: 327-338
29. Agrawal R, Kaur IP. Inhibitory effect of encapsulated curcumin on ultraviolet-induced photoaging in mice. Rejuvenation Res. 2010 ; 13: 397-410
30. Srinivasan M, Sudheer AR, Pillai KR, Kumar PR, Sudhakaran PR, Menon VP. Modulatory effects of curcumin on γ-radiation-induced cellular damage in primary culture of isolated rat hepatocytes. Environ Toxicol Pharmacol. 2007 ; 24: 98-105
31. Nada AS, Hawas AM, Amin Nel-D, Elnashar MM, Abd Elmageed ZY. Radioprotective effect of Curcuma longa extract on γ-irradiation-induced oxidative stress in rats. Can J Physiol Pharmacol. 2012 ; 90: 415-423
32. Sidhu GS, Singh AK, Thaloor D, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 1998 ; 6: 167-177
33. Panchatcharam M, Miriyala S, Gayathri VS, Suguna L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. 2006 ; 290: 87-96
34. Singer AJ, McClain SA, Romanov A, Rooney J, Zimmerman T. Curcumin reduces burn progression in rats. Acad Emerg Med. 2007 ; 14: 1125-1129
35. Rao MC, Sudheendra AT, Nayak PG, Paul P, Kutty GN, Shenoy RR. Effect of dehydrozingerone, a half analog of curcumin on dexamethasone-delayed wound healing in albino rats. Mol Cell Biochem. 2011 ; 355: 249-256
36. Jagetia GC, Rajanikant GK. Effect of curcumin on radiation-impaired healing of excisional wounds in mice. J Wound Care. 2004 ; 13: 107-109
37. Jagetia GC, Rajanikant GK. Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation. J Surg Res. 2004 ; 120: 127-138
38. Jagetia GC, Rajanikant GK. Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation. Plast Reconstr Surg. 2005 ; 115: 515-528
39. Jagetia GC, Rajanikant GK. Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated γ-radiation. Int Wound J. 2012 ; 9: 76-92
40. Mali AM, Behal R, Gilda SS. Comparative evaluation of 0.1% turmeric mouthwash with 0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: a clinical and microbiological study. J Indian Soc Periodontol. 2012 ; 16: 386-391
41. Hastak K, Lubri N, Jakhi SD, et al. Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Lett. 1997 ; 116: 265-269
42. Chainani-Wu N, Madden E, Lozada-Nur F, Silverman S. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. J Am Acad Dermatol. 2012 ; 66: 752-760
43. Cancer Management: A Multidisciplinary Approach. Medical, Surgical, and Radiation Oncology. 12 th ed.Norwalk, CT: CMP Healthcare Media; 2009. Pazdur R Wagman LD Camphausen K Hoskins WJ., ed. Norwalk, CT: CMP Healthcare Media ; 2009 :
44. Madan PD, Sequeira PS, Shenoy K, Shetty J. The effect of three mouthwashes on radiation-induced oral mucositis in patients with head and neck malignancies: a randomized control trial. J Cancer Res Ther. 2008 ; 4: 3-8
45. Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S. The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract. 2008 ; 9: 40-47
46. Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN. Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol. 2009 ; 123: 223-228
47. Bardy J, Molassiotis A, Ryder WD, et al. A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg. 2012 ; 50: 221-226
48. Jayachandran S, Balaji N. Evaluating the effectiveness of topical application of natural honey and benzydamine hydrochloride in the management of radiation mucositis. Indian J Palliat Care. 2012 ; 18: 190-195
49. Maiti PK, Ray A, Mitra TN, Jana U, Bhattacharya J, Ganguly S. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J Indian Med Assoc. 2012 ; 110: 453-456
50. Van den Wyngaert T. Topical honey application to reduce radiation-induced oral mucositis: a therapy too sweet to ignore?. J Evid Based Dent Pract. 2012 ; 12: 203-205
51. Santos-Silva AR, Rosa GB, Eduardo CP, Dias RB, Brandao TB. Increased risk for radiation-related caries in cancer patients using topical honey for the prevention of oral mucositis. Int J Oral Maxillof Surg. 2011 ; 40: 1335-1336
52. Waghmare PF, Chaudhari AU, Karhadkar VM, Jamkhande AS. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study. J Contemp Dent Pract. 2011 ; 12: 221-224
53. Nagpal M, Sood S. Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med. 2013 ; 4: 3-7
54. Chaturvedi TP. Uses of turmeric in dentistry: an update. Indian J Dent Res. 2009 ; 20: 107-109
55. Rosenthal DI. Consequences of mucositis-induced treatment breaks and dose reductions on head and neck cancer treatment outcomes. J Support Oncol. 2007 ; 5: 23-31
56. Conney AH, Lysz T, Ferraro T, et al. Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. Adv Enzyme Regul. 1991 ; 31: 385-396
57. Graf J. Herbal anti-inflammatory agents for skin disease. Skin Ther Lett. 2000 ; 5: 3-5
58. Sharma S, Kulkarni SK, Agrewala JN, Chopra K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pharmacol. 2006 ; 536: 256-261
59. Zhao X, Xu Y, Zhao Q, Chen CR, Liu AM, Huang ZL. Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: descending monoamine system and opioid receptors are differentially involved. Neuropharmacology. 2012 ; 62: 843-854
60. Rezvani M, Ross GA. Modification of radiation-induced acute oral mucositis in the rat. Int J Radiat Biol. 2004 ; 80: 177-182
61. Gibson RJ, Bowen JM, Cummins AG, Logan R, Healey T, Keefe DM. Ultrastructural changes occur early within the oral mucosa following cancer chemotherapy. Support Care Cancer. 2004 ; 12: 389
62. Logan RM, Gibson RJ, Sonis ST, Keefe DM. Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. Oral Oncol. 2007 ; 43: 395-401
63. Raber-Durlacher JE, Elad S, Barasch A. Oral mucositis. Oral Oncol. 2010 ; 46: 452-456
64. Kim KJ, Yu HH, Cha JD, Seo SJ, Choi NY, You YO. Antibacterial activity of Curcuma longa L. against methicillin-resistant Staphylococcus aureus. Phytother Res. 2005 ; 19: 599-604
65. Lüer S, Troller R, Jetter M, Spaniol V, Aebi C. Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells in vitro: potential role for patients with cancer therapy induced mucositis?. Support Care Cancer. 2011 ; 19: 799-806
66. Lüer S, Troller R, Aebi C. Antibacterial and anti-inflammatory kinetics of curcumin as a potential antimucositis agent in cancer patients. Nutr Cancer. 2012 ; 64: 975-981
67. López-Jornet P, Camacho-Alonso F, Jiménez-Torres MJ, Orduña-Domingo A, Gómez-García F. Topical curcumin for the healing of carbon dioxide laser skin wounds in mice. Photomed Laser Surg. 2011 ; 29: 809-814