Curcumin Reduces Burn Progression in Rats

Academic Emergency Medicine

Volumn 14, Issue 12, 2007, Pages 1125-1129

  Singer, Adam J ^a   McClain, Steve A ^a   Romanov, Alexander ^a   Rooney, Jean ^a   Zimmerman, Tom ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

burns; curcumin; ischemia; stasis

Indexed keywords

CURCUMIN; EOSIN; HEMATOXYLIN;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CHI SQUARE TEST; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEEDING; MALE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; RAT; SKIN BIOPSY;

ANIMALS; ANTIOXIDANTS; BURNS; CURCUMIN; MALE; NECROSIS; OXIDATIVE STRESS; PROSPECTIVE STUDIES; RATS; RATS, SPRAGUE-DAWLEY; WOUND HEALING;

EID: 36248977012     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1197/j.aem.2007.07.012     Document Type: Article

References (37)

1. Brigham P.A., and McLoughlin E. Burn incidence and medical care use in the United States: estimate, trends, and data sources. J Burn Care Rehabil 17 (1996) 95-107
2. American Burn Association. Home page. Available at: http://www.ameriburn.org. Accessed May 7, 2007.
3. Jackson D. The diagnosis of the depth of burning. Br J Surg 40 (1953) 588-596
4. Papp A., Kiraly K., Harma M., et al. The progression of burn depth in experimental burns: a histological and methodological study. Burns 30 (2004) 684-690
5. Arturson G. Pathophysiology of the burn wound and pharmacological treatment: the Rudi Hermans Lecture. Burns 22 (1996) 255-274
6. Arturson G. Forty years in burns research-the postburn inflammatory response. Burns 26 (2000) 599-604
7. Atiyeh B.S., Gunn W., and Hayek S.N. State of the art in burn treatment. World J Surg 29 (2005) 131-148
8. Ammon H.P., and Wahl M.A. Pharmacology of Curcuma longa. Planta Medica 57 (1991) 1-7
9. Srimal R.C., and Dhawan B.N. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol 25 (1973) 447-452
10. Satoskar R.R., Shah S.J., and Shenoy S.G. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol 24 (1986) 651-654
11. Kuttan R., Bhanumathy P., Nirmala K., and George M.C. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett 129 (1985) 197-202
12. Sharma O.P. Antioxidant activity of curcumin and related compounds. Biochem Pharmacol 25 (1976) 1811-1812
13. Toda S., Miyase T., Arichi H., Tanizawa H., and Takino Y. Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem Pharm Bull (Tokyo) 33 (1985) 1725-1728
14. Sidhu G.S., Singh A.K., Thaloor D., et al. Enhancement of wound healing by curcumin in animals. Wound Rep Regen 6 (1998) 167-177
15. Negi P.S., Jayaprakasha G.K., Jagan Mohan Rao L., and Sakariah K.K. Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. J Agric Food Chem 47 (1999) 4297-4300
16. Regas F.C., and Ehrlic H.P. Elucidating the vascular response to burns by a new rat model. J Trauma 32 (1992) 556-563
17. Choi M., and Ehrlich P. U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model. Am J Pathol 142 (1993) 519-528
18. National Research Council. Guide for the Care and Use of Laboratory Animals (1996), National Academy Press, Washington, DC
19. Jagetia G.C., and Rajanikant G.K. Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation. Plast Reconstr Surg 115 (2005) 515-528
20. Singer A.J., McClain S.A., Zimmerman T., et al. The effect of N-acetyl cysteine in burn progression in rats. [abstract]. Acad Emerg Med 14 (2007) S21
21. Cohen J. Statistical Power Analysis for the Behavioral Sciences (1988), Lawrence Erlbaum Associates, Hillsdale, NJ
22. Reddy A.C., and Lokesh B.R. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol Cell Biochem 137 (1994) 1-8
23. Unnikrishnan M.K., and Rao M.N. Curcumin inhibits nitrogen dioxide induced oxidation of hemoglobin. Mol Cell Biochem 146 (1995) 35-37
24. Sreejayan, and Rao M.N. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol 49 (1997) 105-107
25. Reddy A.C., and Lokesh B.R. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem 111 (1992) 117-124
26. 2-induced renal epithelial (LLC-PK1) cell injury. Free Radic Biol Med 24 (1998) 49-54
27. Dikshit M., Rastogi L., Shukla R., and Srimal R.C. Prevention of ischaemia-induced biochemical changes by curcumin and quinidine in the cat heart. Indian J Med Res 101 (1995) 31-35
28. Motterlini R., Foresti R., Bassi R., and Green C.J. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28 (2000) 1303-1312
29. Gaddipati J.P., Sundar S.V., Calemine J., Seth P., Sidhu G.S., and Maheshwari R.K. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/ resuscitation. Shock 19 (2003) 150-156
30. Calabrese V., Butterfield D.A., and Stella A.M. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem 52 (2003) 177-181
31. Yang F., Lim G.P., Begum A.N., et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280 (2005) 5892-5901
32. Nadkarni K.M. Curcuma longa. In: Nadkarni K.M. (Ed). Indian Materia Medica (1976), Popular Prakashan Publishing, Bombay, India 414-416
33. Sidhu G.S., Mani H., Gaddipati J.P., et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 7 (1999) 362-374
34. Mani H., Sidhu G.S., Kumari R., Gaddipati J.P., Seth P., and Maheshwari R.K. Curcumin differentially regulates TGF-β1, its receptors and nitric oxide synthase during impaired wound healing. BioFactors 16 (2002) 29-43
35. Phan T.T., Sun L., Bay B.H., Chan S.Y., and Lee S.T. Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. J Trauma 54 (2003) 1212-1224
36. Gopinath, Ahmed M.R., Gomathi K., Chitra K., Sehgal P.K., and Jayakumar R. Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 25 (2004) 1911-1917
37. Swarnakar S., Ganguly K., Kundu P., Banerjee A., Maity P., and Sharma A.V. Curcumin regulates expression and activity of matrix metalloproteinases-9 and -2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 280 (2005) 9409-9415