SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2693-2698

Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs

(5) Wenthur, Cody J a Morrison, Ryan D a Daniels, J Scott a Conn, P Jeffrey a Lindsley, Craig W a,b

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

b VANDERBILT UNIVERSITY (United States)

Author keywords

Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 3; Negative allosteric modulator (NAM)

Indexed keywords

4 METHYL 2 PHENYL 8 (PYRIMIDIN 5 YL)PYRAZOLO[1,5 A]QUINAZOLIN 5(4H) ONE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR ANTAGONIST; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; METABOTROPIC RECEPTOR; PYRAZOLE DERIVATIVE;

ARTICLE; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; ALLOSTERISM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; IC50; METABOLISM; SYNTHESIS;

ALLOSTERIC REGULATION; DRUG DESIGN; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRAZOLES; QUINAZOLINES; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84900791886 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.04.051 Document Type: Article

Times cited : (23)

References (28)

1
- 0030995878
- P.J. Conn, and J.-P. Pin Annu. Rev. Pharmacol. Toxicol. 37 1997 205
- (1997) Annu. Rev. Pharmacol. Toxicol. , vol.37 , pp. 205
- Conn, P.J.¹ Pin, J.-P.²

2
- 84857375139
- B.J. Melancon, C.R. Hopkins, M.R. Wood, K.A. Emmitte, C.M. Niswender, A. Christopolous, P.J. Conn, and C.W. Lindsley J. Med. Chem. 55 2012 1445
- (2012) J. Med. Chem. , vol.55 , pp. 1445
- Melancon, B.J.¹ Hopkins, C.R.² Wood, M.R.³ Emmitte, K.A.⁴ Niswender, C.M.⁵ Christopolous, A.⁶ Conn, P.J.⁷ Lindsley, C.W.⁸

3
- 65749093108
- P.J. Conn, A. Christopolous, and C.W. Lindsley Nat. Rev. Drug Disc. 8 2009 41
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 41
- Conn, P.J.¹ Christopolous, A.² Lindsley, C.W.³

4
- 58149119377
- P.J. Conn, C.W. Lindsley, and C. Jones Trends Pharmacol. Sci. 30 2009 25
- (2009) Trends Pharmacol. Sci. , vol.30 , pp. 25
- Conn, P.J.¹ Lindsley, C.W.² Jones, C.³

5
- 39449104625
- P.J. Harrision, L. Lyon, L.J. Sartorius, P.W.J. Burnet, and T.A. Lane J. Psychopharmacol. 22 2008 308
- (2008) J. Psychopharmacol. , vol.22 , pp. 308
- Harrision, P.J.¹ Lyon, L.² Sartorius, L.J.³ Burnet, P.W.J.⁴ Lane, T.A.⁵

6
- 23244464989
- A. Palucha, and A. Pilc Drug News Perspect. 4 2005 262
- (2005) Drug News Perspect. , vol.4 , pp. 262
- Palucha, A.¹ Pilc, A.²

7
- 34547397923
- F. Matrrisciano, I. Panaccione, M. Zusso, P. Giusti, R. Tatarelli, L. Iacovelli, A.A. Mathé, S.H.M. Gruber, F. Nicoletti, and P. Giardi Mol. Psychiatry 12 2007 704
- (2007) Mol. Psychiatry , vol.12 , pp. 704
- Matrrisciano, F.¹ Panaccione, I.² Zusso, M.³ Giusti, P.⁴ Tatarelli, R.⁵ Iacovelli, L.⁶ Mathé, A.A.⁷ Gruber, S.H.M.⁸ Nicoletti, F.⁹ Giardi, P.¹⁰

8
- 84900804187
- N. Pistakas Eur. J. Pharmacol. 723 2014 181
- (2014) Eur. J. Pharmacol. , vol.723 , pp. 181
- Pistakas, N.¹

9
- 70349782435
- M.F. Olive Curr. Drug Abuse Rev. 2 2009 83
- (2009) Curr. Drug Abuse Rev. , vol.2 , pp. 83
- Olive, M.F.¹

10
- 0033602516
- J.A. Monn, M.J. Valli, S.M. Massey, M.M. Hansen, T.J. Kress, J.P. Wepsiec, A.R. Harkness, J.L. Grutch Jr., R.A. Wright, B.G. Johnson, S.L. Andis, A.E. Kingston, T. Rosemarie, R. Lewis, K.R. Griffey, J.P. Tizzano, and D.D. Schoepp J. Med. Chem. 42 1999 1027
- (1999) J. Med. Chem. , vol.42 , pp. 1027
- Monn, J.A.¹ Valli, M.J.² Massey, S.M.³ Hansen, M.M.⁴ Kress, T.J.⁵ Wepsiec, J.P.⁶ Harkness, A.R.⁷ Grutch Jr., J.L.⁸ Wright, R.A.⁹ Johnson, B.G.¹⁰ Andis, S.L.¹¹ Kingston, A.E.¹² Rosemarie, T.¹³ Lewis, R.¹⁴ Griffey, K.R.¹⁵ Tizzano, J.P.¹⁶ Schoepp, D.D.¹⁷

11
- 0031808420
- A.E. Kingston, P.L. Ornstein, R.A. Wright, B.G. Johnson, N.G. Mayne, J.P. Burnett, R. Belagaje, S. Wu, and D.D. Schoepp Neuropharmacology 37 1998 1
- (1998) Neuropharmacology , vol.37 , pp. 1
- Kingston, A.E.¹ Ornstein, P.L.² Wright, R.A.³ Johnson, B.G.⁴ Mayne, N.G.⁵ Burnett, J.P.⁶ Belagaje, R.⁷ Wu, S.⁸ Schoepp, D.D.⁹

12
- 84872156125
- R.A. Wright, B.G. Johnson, C. Zhang, C. Salhoff, A.E. Kingston, D.O. Calligaro, J.A. Monn, D.D. Schoepp, and G.J. Marek Neuropharmacology 66 2013 89
- (2013) Neuropharmacology , vol.66 , pp. 89
- Wright, R.A.¹ Johnson, B.G.² Zhang, C.³ Salhoff, C.⁴ Kingston, A.E.⁵ Calligaro, D.O.⁶ Monn, J.A.⁷ Schoepp, D.D.⁸ Marek, G.J.⁹

13
- 68949151921
- G. Battaglia, G. Molinaro, B. Riozzi, M. Storto, C.L. Busceti, P. Spinsanti, D. Bucci, V. Di Liberto, G. Mudó, C. Corti, M. Corsi, F. Nicoletti, N. Belluardo, and V. Bruno PLoS One 8 2009 e6591
- (2009) PLoS One , vol.8 , pp. 6591
- Battaglia, G.¹ Molinaro, G.² Riozzi, B.³ Storto, M.⁴ Busceti, C.L.⁵ Spinsanti, P.⁶ Bucci, D.⁷ Di Liberto, V.⁸ Mudó, G.⁹ Corti, C.¹⁰ Corsi, M.¹¹ Nicoletti, F.¹² Belluardo, N.¹³ Bruno, V.¹⁴

14
- 84872150119
- L. Hanna, L. Ceolin, S. Lucas, J.A. Monn, B.G. Johnson, G. Collingridge, B. Zuner, and D. Lodge Neuropharmacology 66 2013 114
- (2013) Neuropharmacology , vol.66 , pp. 114
- Hanna, L.¹ Ceolin, L.² Lucas, S.³ Monn, J.A.⁴ Johnson, B.G.⁵ Collingridge, G.⁶ Zuner, B.⁷ Lodge, D.⁸

15
- 33746106504
- A.-M. Linden, M. Baez, M. Bergeron, and D.D. Shoepp Neuropharmacology 51 2006 213
- (2006) Neuropharmacology , vol.51 , pp. 213
- Linden, A.-M.¹ Baez, M.² Bergeron, M.³ Shoepp, D.D.⁴

16
- 34547686245
- C. Corti, G. Battaglia, G. Molinaro, B. Riozzi, A. Pittaluga, M. Corsi, M. Mugnaini, F. Nicoletti, and V. Bruno Neuroscience 27 2007 8297
- (2007) Neuroscience , vol.27 , pp. 8297
- Corti, C.¹ Battaglia, G.² Molinaro, G.³ Riozzi, B.⁴ Pittaluga, A.⁵ Corsi, M.⁶ Mugnaini, M.⁷ Nicoletti, F.⁸ Bruno, V.⁹

17
- 79951975389
- F. Caraci, G. Molinaro, G. Battaglia, M.L. Giuffrida, B. Riozzi, A. Trafficante, V. Bruno, M. Cannella, S. Merlo, X. Wang, B.A. Heinz, E.S. Nisenbaum, T.C. Britton, F. Drago, M.A. Sortino, A. Copani, and F. Nicoletti Mol. Pharmacol. 79 2011 618
- (2011) Mol. Pharmacol. , vol.79 , pp. 618
- Caraci, F.¹ Molinaro, G.² Battaglia, G.³ Giuffrida, M.L.⁴ Riozzi, B.⁵ Trafficante, A.⁶ Bruno, V.⁷ Cannella, M.⁸ Merlo, S.⁹ Wang, X.¹⁰ Heinz, B.A.¹¹ Nisenbaum, E.S.¹² Britton, T.C.¹³ Drago, F.¹⁴ Sortino, M.A.¹⁵ Copani, A.¹⁶ Nicoletti, F.¹⁷

18
- 80051770211
- D.J. Sheffler, A.B. Pinkerton, R. Dahl, A. Markou, and N.D.P. Cosford ACS Chem. Neurosci. 2 2011 382
- (2011) ACS Chem. Neurosci. , vol.2 , pp. 382
- Sheffler, D.J.¹ Pinkerton, A.B.² Dahl, R.³ Markou, A.⁴ Cosford, N.D.P.⁵

19
- 78149496159
- P. Keov, P. Sexton, and A. Christopoulos Neuropharmacology 60 2011 24
- (2011) Neuropharmacology , vol.60 , pp. 24
- Keov, P.¹ Sexton, P.² Christopoulos, A.³

20
- 84867805389
- J.-I. Andres, J. Alcàzar, J.M. Cid, M. De Angelis, L. Iturrino, X. Langlois, H. Lavreysen, A.A. Trabanco, S. Celen, and G.M. Bormans J. Med. Chem. 55 2012 8685
- (2012) J. Med. Chem. , vol.55 , pp. 8685
- Andres, J.-I.¹ Alcàzar, J.² Cid, J.M.³ De Angelis, M.⁴ Iturrino, L.⁵ Langlois, X.⁶ Lavreysen, H.⁷ Trabanco, A.A.⁸ Celen, S.⁹ Bormans, G.M.¹⁰

21
- 84879558600
- C.J. Wenthur, R. Morrison, A.S. Felts, K.A. Smith, J.L. Engers, F.W. Byers, J.S. Daniels, K.A. Emmitte, P.J. Conn, and C.W. Lindsley J. Med. Chem. 56 2013 5208
- (2013) J. Med. Chem. , vol.56 , pp. 5208
- Wenthur, C.J.¹ Morrison, R.² Felts, A.S.³ Smith, K.A.⁴ Engers, J.L.⁵ Byers, F.W.⁶ Daniels, J.S.⁷ Emmitte, K.A.⁸ Conn, P.J.⁹ Lindsley, C.W.¹⁰

22
- 84900835891
- Merck Sharp & Dohme Corp. International Patent Application PCT/US2012/062027
- Merck Sharp & Dohme Corp. International Patent Application PCT/US2012/062027, 2012.
- (2012)

23
- 84900818951
- GPCR/Membrane Protein Targets Brochure
- Boston, MA, Sept 24-26
- Schann, S. GPCR/Membrane Protein Targets Brochure, 11th Annual Discovery on Target Meeting, Boston, MA, Sept 24-26, 2013.
- (2013) 11th Annual Discovery on Target Meeting
- Schann, S.¹

24
- 84900834302
- General Poster Session - EVE Session
- Indianapolis, IN, Sept 8-12
- Schann, S.; Manteau, B.; Franchet, C.; Frauli, M.; Mayer, S. General Poster Session - EVE Session, 246th ACS National Meeting and Exposition, Indianapolis, IN, Sept 8-12, 2013.
- (2013) 246th ACS National Meeting and Exposition
- Schann, S.¹ Manteau, B.² Franchet, C.³ Frauli, M.⁴ Mayer, S.⁵

25
- 47149106805
- S. Sharma, A. Rodriguez, P.J. Conn, and C.W. Lindsley Bioorg. Med. Chem. Lett. 18 2008 4098
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4098
- Sharma, S.¹ Rodriguez, A.² Conn, P.J.³ Lindsley, C.W.⁴

26
- 67650729937
- S. Sharma, J. Kedrowski, J.M. Rook, R.L. Smith, C.K. Jones, A.L. Rodriguez, P.J. Conn, and C.W. Lindsley J. Med. Chem. 52 2010 4103
- (2010) J. Med. Chem. , vol.52 , pp. 4103
- Sharma, S.¹ Kedrowski, J.² Rook, J.M.³ Smith, R.L.⁴ Jones, C.K.⁵ Rodriguez, A.L.⁶ Conn, P.J.⁷ Lindsley, C.W.⁸

27
- 80255129374
- T. Utley, D. Haddenham, J.M. Salovich, R. Zamorano, P.N. Vinson, C.W. Lindsley, C.R. Hopkins, and C.M. Niswender Bioorg. Med. Chem. Lett. 21 2011 6955
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 6955
- Utley, T.¹ Haddenham, D.² Salovich, J.M.³ Zamorano, R.⁴ Vinson, P.N.⁵ Lindsley, C.W.⁶ Hopkins, C.R.⁷ Niswender, C.M.⁸

28
- 78650379605
- S. Schann, S. Mayer, C. Franchet, M. Frauli, E. Steinberg, M. Thomas, L. Baron, and P. Neuville J. Med. Chem. 53 2010 8775
- (2010) J. Med. Chem. , vol.53 , pp. 8775
- Schann, S.¹ Mayer, S.² Franchet, C.³ Frauli, M.⁴ Steinberg, E.⁵ Thomas, M.⁶ Baron, L.⁷ Neuville, P.⁸

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.