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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 6955-6959

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu 4) antagonist: Unexpected 'molecular switch' from a closely related mGlu 4 positive allosteric modulator

(8) Utley, Thomas a Haddenham, Dustin a Salovich, James M a,b Zamorano, Rocio a Vinson, Paige N a Lindsley, Craig W a,b,c Hopkins, Corey R a,b,c Niswender, Colleen M a

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

b VANDERBILT UNIVERSITY MEDICAL CENTER (United States)

c VANDERBILT UNIVERSITY (United States)

Author keywords

Antagonist; Metabotropic glutamate receptor 4; mGlu 4; Molecular switch

Indexed keywords

GLUTAMIC ACID; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; VU 0448383;

ALLOSTERISM; ARTICLE; DRUG MECHANISM; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; CELLS, CULTURED; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80255129374 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.09.131 Document Type: Article

Times cited : (18)

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