Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potential

Toxicology in Vitro

Volumn 15, Issue 4-5, 2001, Pages 579-584

  Evans, S M ^a   Casartelli, A ^b   Herreros, E ^c   Minnick, D T ^b   Day, C ^a   George, E ^a   Westmoreland, C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (Spain)

Author keywords

Acute in vivo toxicity; Chinese hamster ovary (CHO); Cytotoxicity; High throughput; In vitro in vivo correlation; Predictive; Resazurin; Screen; Validation

Indexed keywords

2,4 DINITROPHENOL; BENZETHONIUM CHLORIDE; CARMUSTINE; CHLORAMPHENICOL DERIVATIVE; CHLORMETHINE; CHLORPROMAZINE; CHROMOMYCIN; CISPLATIN; COLCHICINE; CYCLOHEXIMIDE; DACTINOMYCIN; DAUNORUBICIN; DIETHYLSTILBESTROL; DODECYL SULFATE SODIUM; DOXORUBICIN; MELPHALAN; MERCURIC CHLORIDE; MITHRAMYCIN; PODOPHYLLOTOXIN; RESAZURIN; RETINOIC ACID; ROTENONE; STREPTOZOCIN; TIOGUANINE; VIDARABINE; VINBLASTINE; VINCRISTINE SULFATE;

ACCURACY; ACUTE TOXICITY; ANALYTIC METHOD; ANIMAL CELL; CELL LINE; CHEMICAL STRUCTURE; CHO CELL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOTOXICITY; DATA BASE; DRUG SCREENING; IN VITRO STUDY; IN VIVO STUDY; ITALY; LD 50; LETHAL DOSE; NONHUMAN; PREDICTION; REPRODUCIBILITY; SPAIN; UNITED STATES; VALIDATION PROCESS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CHO CELLS; CRICETINAE; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; INDICATORS AND REAGENTS; MICE; OXAZINES; PREDICTIVE VALUE OF TESTS; RATS; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS; XANTHENES;

EID: 0034833013     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(01)00064-9     Document Type: Conference Paper

References (12)

1. Reduction of the new tetrazolium dye, Alamar Blue™, in cultured rat hepatocytes and liver fractions
2. Practical aspects of the validation of toxicity test procedures
3. Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals
4. Screening of toxic compounds in mammalian cell cultures
5. A multicentre study of acute in vitro cytotoxicity in rat hepatocytes: Tentative correlation between in vitro toxicities and in vivo data
6. First results from the MEIC program
7. Choic of acute toxicity measures for comparison of in vivo/in vitro toxicity
8. Correlation of acute lethal potency with in vitro cytotoxicity
9. In vitro cytotoxicity tests for the prediction of acute toxicity in vivo
10. 50 testing? Validation of a predictive model by multivariate analysis