메뉴 건너뛰기




Volumn 149, Issue 1-3, 2004, Pages 371-375

Progress in applying genomics in drug development

Author keywords

Mechanism based risk assessment; Predictive toxicology; Review; Toxicogenomics

Indexed keywords

CARCINOGEN; POTASSIUM BROMATE; XENOBIOTIC AGENT;

EID: 1842766394     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.12.045     Document Type: Conference Paper
Times cited : (30)

References (21)
  • 3
    • 0032808416 scopus 로고    scopus 로고
    • Gene expression applied to toxicology
    • Farr S., Dunn R.T. Gene expression applied to toxicology. Toxicol. Sci. 50:1999;1-9.
    • (1999) Toxicol. Sci. , vol.50 , pp. 1-9
    • Farr, S.1    Dunn, R.T.2
  • 4
    • 0035092715 scopus 로고    scopus 로고
    • Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology
    • Fielden M.R., Zacharewski T.R. Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicol. Sci. 60:2001;6-10.
    • (2001) Toxicol. Sci. , vol.60 , pp. 6-10
    • Fielden, M.R.1    Zacharewski, T.R.2
  • 5
    • 0030952485 scopus 로고    scopus 로고
    • Expression of growth factor receptors and their mRNAs in livers of mice and rats following administration of non-genotoxic carcinogens
    • Garcia-Allan C., Loughlin J., Orton T.C., Lord P.G. Expression of growth factor receptors and their mRNAs in livers of mice and rats following administration of non-genotoxic carcinogens. Arch. Toxicol. 71:1997;409-415.
    • (1997) Arch. Toxicol. , vol.71 , pp. 409-415
    • Garcia-Allan, C.1    Loughlin, J.2    Orton, T.C.3    Lord, P.G.4
  • 7
    • 0034825987 scopus 로고    scopus 로고
    • The use of genomics technology to investigate gene expression changes in cultured human liver cells
    • Harries H.M., Fletcher S.T., Duggan C.M., Baker V.A. The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol. In Vitro. 15:2001;399-405.
    • (2001) Toxicol. in Vitro , vol.15 , pp. 399-405
    • Harries, H.M.1    Fletcher, S.T.2    Duggan, C.M.3    Baker, V.A.4
  • 10
    • 0035152959 scopus 로고    scopus 로고
    • CDNA microarrays in investigative toxicology: A study of differential gene expression in compound induced cardiac hypertrophy
    • Lord P.G., Barne K.A., Kramer K., Bacon E.J., Mooney J., O'Brien S., Bugelski P.J. cDNA microarrays in investigative toxicology: a study of differential gene expression in compound induced cardiac hypertrophy. Comments Toxicol. 7:2001;381-392.
    • (2001) Comments Toxicol. , vol.7 , pp. 381-392
    • Lord, P.G.1    Barne, K.A.2    Kramer, K.3    Bacon, E.J.4    Mooney, J.5    O'Brien, S.6    Bugelski, P.J.7
  • 13
    • 0029941161 scopus 로고    scopus 로고
    • Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone
    • Orton T.C., Doughty S.E., Kalinowski A.E., Lord P.G., Wadsworth P.F. Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone. Carcinogenesis. 15:1996;973-981.
    • (1996) Carcinogenesis , vol.15 , pp. 973-981
    • Orton, T.C.1    Doughty, S.E.2    Kalinowski, A.E.3    Lord, P.G.4    Wadsworth, P.F.5
  • 15
    • 0032779706 scopus 로고    scopus 로고
    • Differential gene expression in drug metabolism and toxicology: Practicalities
    • Rockett J.C., Esdaile D.J., Gibson G.G. Differential gene expression in drug metabolism and toxicology: practicalities. Xenobiotica. 29:1999;655-691.
    • (1999) Xenobiotica , vol.29 , pp. 655-691
    • Rockett, J.C.1    Esdaile, D.J.2    Gibson, G.G.3
  • 16
    • 0028041828 scopus 로고
    • Effect of some peroxisome proliferators on transforming growth factor-b1 gene expression and insulin-like growth factor II/mannose-6-phosphate receptor gene expression in rat liver
    • Rumsby P.C., Davies M.J., Price R.J., Lake B.G. Effect of some peroxisome proliferators on transforming growth factor-b1 gene expression and insulin-like growth factor II/mannose-6-phosphate receptor gene expression in rat liver. Carcinogenesis. 15:1994;419-421.
    • (1994) Carcinogenesis , vol.15 , pp. 419-421
    • Rumsby, P.C.1    Davies, M.J.2    Price, R.J.3    Lake, B.G.4
  • 17
    • 0035369987 scopus 로고    scopus 로고
    • Key challenges for toxicologists in the 21st century
    • Smith L.L. Key challenges for toxicologists in the 21st century. Trends Pharmacol. Sci. 22:2001;281-285.
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 281-285
    • Smith, L.L.1
  • 19
    • 0036043671 scopus 로고    scopus 로고
    • Toxicogenomics and drug discovery: Will new technologies help us produce better drugs?
    • Ulrich R., Friend S.H. Toxicogenomics and drug discovery: will new technologies help us produce better drugs? Nature Rev. Drug Discovery. 1:2002;84-88.
    • (2002) Nature Rev. Drug Discovery , vol.1 , pp. 84-88
    • Ulrich, R.1    Friend, S.H.2
  • 20
    • 0021697881 scopus 로고
    • The molecular genetics of cellular oncogenes
    • Varmus H.E. The molecular genetics of cellular oncogenes. Annu. Rev. Genet. 18:1985;553-612.
    • (1985) Annu. Rev. Genet. , vol.18 , pp. 553-612
    • Varmus, H.E.1
  • 21
    • 0035977845 scopus 로고    scopus 로고
    • Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity
    • Waring J.F., Ciurlionis R., Jolly R.A., Heindel M., Ulrich R.G. Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol. Lett. 120:2001;359-368.
    • (2001) Toxicol. Lett. , vol.120 , pp. 359-368
    • Waring, J.F.1    Ciurlionis, R.2    Jolly, R.A.3    Heindel, M.4    Ulrich, R.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.