Effect of systemic carnitine therapy on serum fibronectin level in diabetic rats

Journal of Surgical Research

Volumn 187, Issue 2, 2014, Pages 712-717

  Kömürcü, Erkam ^a   Özkan, Ömer Faruk ^a   Kemik, Ahu Sarbay ^b   Nusran, Gürdal ^a   Aşik, Mehmet ^a   Arslan, Emrah ^a  

^a ÇANAKKALE ONSEKIZ MART UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Carnitine; Diabetes mellitus; Fibronectin; Flap viability

Indexed keywords

CARNITINE; FIBRONECTIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; FULL THICKNESS SKIN GRAFT; HIP; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SCAPULA; SYSTEMIC THERAPY;

CARNITINE; DIABETES MELLITUS; FIBRONECTIN; FLAP VIABILITY;

ANIMALS; BLOOD GLUCOSE; CARNITINE; DIABETES MELLITUS, EXPERIMENTAL; FIBRONECTINS; GRAFT SURVIVAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; SKIN TRANSPLANTATION; SURGICAL FLAPS; VITAMIN B COMPLEX; WOUND HEALING;

EID: 84900559494     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.11.1101     Document Type: Article

References (26)

1. N.N. Le, M.B. Rose, H. Levinson, and B. Klitzman Implant healing in experimental animal models of diabetes J Diabetes Sci Technol 5 2011 605
2. S. Hamed, Y. Ullmann, and D. Egozi et al. Fibronectin potentiates topical erythropoietin-induced wound repair in diabetic mice J Invest Dermatol 131 2011 1365
3. Z. Qiu, A.H. Kwon, and Y. Kamiyama Effects of plasma fibronectin on the healing of full-thickness skin wounds in streptozotocin-induced diabetic rats J Surg Res 138 2007 64
4. A.H. Kwon, Z. Qiu, and Y. Hiraon Effect of plasma fibronectin on the incisional wound healing in rats Surgery 141 2007 254
5. M. Nakada, K. Nakada, and H. Kitagawa et al. Efficacy of exogenous fibronectin in wound healing in malnourished rats J Pediatr Surg 33 1998 1699
6. I. Tein Carnitine transport: pathophysiology and metabolism of known molecular defects J Inherit Metab Dis 26 2003 147
7. A. Akkus, K. Aydinuraz, and C. Daphan et al. Effect of carnitine on cutaneous wound healing in immunosuppressed rats J Surg Res 155 2009 301
8. J.R. Williamson, and E. Arrigoni-Martelli The roles of glucose-induced metabolic hypoxia and imbalances in carnitine metabolism in mediating diabetes-induced vascular dysfunction Int J Clin Pharmacol Res 12 1992 247
9. V.A. Keller, B. Toporoff, and R.M. Raziano et al. Carnitine supplementation improves myocardial function in hearts from ischemic diabetic and euglycemic rats Ann Thorac Surg 66 1998 1600
10. O. Ergun, C. Ulman, A.S. Kilicalp, and I. Ulman Carnitine as a preventive agent in experimental renal ischemia-reperfusion injury Urol Res 29 2001 186
11. R.K. Khouri, M.F. Angel, and L.E. Edstrom Standardizing the dorsal rat flap Surg Forum 37 1986 590
12. G.R. Godoy, R.E. Liebano, and J.B. Correa et al. Capsaicin on the viability of random-pattern skin flaps in rats Acta Cir Bras 25 2010 440
13. E. Rubli, S. Bussard, and E. Frei et al. Plasma fibronectin and associated variables in surgical intensive care patients Ann Surg 197 1983 310
14. S.M. Barral, I.D. Araujo, and P.V. Vidigal et al. Effects of sildenafil on the viability of random skin flaps Acta Cir Bras 26 2011 314
15. D.A. Rees, and J.C. Alcolado Animal models of diabetes mellitus Diabet Med 22 2005 359
16. B.J. Hoogwerf Postoperative management of the diabetic patient Med Clin North Am 85 2001 1213
17. K. Hehenberger, J.D. Heilborn, K. Brismar, and A. Hansson Inhibited proliferation of fibroblasts derived from chronic diabetic wounds and normal dermal fibroblasts treated with high glucose is associated with increased formation of l-lactate Wound Repair Regen 6 1998 135
18. H.P. Shi, D. Most, and D.T. Efron et al. Supplemental L-arginine enhances wound healing in diabetic rats Wound Repair Regen 11 2003 198
19. A.T. Tellioglu, K.A. Uras, and T. Yilmaz et al. The effect of carnitine on random-pattern flap survival in rats Plast Reconstr Surg 108 2001 959
20. E. Arslan, A. Milcan, and S. Unal et al. The effects of carnitine on distally-burned dorsal skin flap: an experimental study in rats Burns 29 2003 221
21. T. Karsidag, J.A. Asensio, F. Kabukcuoglu, and S. Tuzun Preliminary study comparing the effects of locally and systemically applied L-carnitine on the healing of full-thickness skin defects Scand J Surg 99 2010 147
22. E. Kargi, O. Deren, and O. Babuccu et al. Dual synergistic effect: the effect of dexamethasone plus carnitine on skin flap survival Ann Plast Surg 53 2004 488
23. E. Arslan, O.G. Ozturk, A. Aksoy, and G. Polat Vacuum-assisted closure therapy leads to an increase in plasma fibronectin level Int Wound J 8 2011 224
24. O.F. Ozkan, E. Komurcu, and M.K. Arik et al. Relationship between serum fibronectin levels and carnitine administration: an experimental study in rats Int Wound J 2013
25. M.B. Witte, T. Kiyama, and A. Barbul Nitric oxide enhances experimental wound healing in diabetes Br J Surg 89 2002 1594
26. T. Koeck, and K. Kremser L-Carnitine alters nitric oxide synthase activity in fibroblasts depending on the peroxisomal status Int J Biochem Cell Biol 35 2003 149