Fibronectin potentiates topical erythropoietin-induced wound repair in diabetic mice

Journal of Investigative Dermatology

Volumn 131, Issue 6, 2011, Pages 1365-1374

  Hamed, Saher ^a,b   Ullmann, Yehuda ^a,b   Egozi, Dana ^b   Daod, Essam ^b   Hellou, Elias ^a   Ashkar, Manal ^b   Gilhar, Amos ^b   Teot, Luc ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Remedor Biomed ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ERYTHROPOIETIN; FIBRIN; FIBRONECTIN; GLUCOSE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; EXCISION; FIBROBLAST; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CELL; SKIN INJURY; WOUND CLOSURE; WOUND HEALING;

EID: 79956055828     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.15     Document Type: Article

References (43)

1. Alvarez Arroyo MV, Castilla MA, González Pacheco FR et al. (1998) Role of vascular endothelial growth factor on erythropoietin-related endothelial cell proliferation. J Am Soc Nephrol 9:1998-2004 (Pubitemid 28482147)
2. Anagnostou A, Lee ES, Kessimian N et al. (1990) Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA 87:5978-82
3. Beer HD, Longaker MT, Werner S (1997) Reduced expression of PDGF and PDGF receptors during impaired wound healing. J Invest Dermatol 109:132-8 (Pubitemid 27337325)
4. Bodo E, Kromminga A, Funk W et al. (2007) Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. FASEB J 21:3346-54 (Pubitemid 47565553)
5. Brines M (2010) The therapeutic potential of erythropoiesis-stimulating agents for tissue protection: a tale of two receptors. Blood Purif 29:86-92
6. Brines M, Cerami A (2008) Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response. J Intern Med 264:405-32
7. Brown LF, Yeo KT, Berse B et al. (1992) Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176:1375-9
8. Buemi M, Galeano M, Sturiale A et al. (2004) Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds. Shock 22:169-73 (Pubitemid 40228196)
9. Buemi M, Vaccaro M, Sturiale A et al. (2002) Recombinant human erythropoietin influences revascularization and healing in a rat model of random ischaemic flaps. Acta Derm Venereol 82:411-7 (Pubitemid 36140240)
10. Clark R (1985) Cutaneous tissue repair: basic biological consideration I. J Am Acad Dermatol 13:701-25 (Pubitemid 16245140)
11. Doupis J, Rahangdale S, Gnardellis C et al. (2010) Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines, and growth factors. Obesity (Silver Spring); e-pub ahead of print 9 September 2010
12. Erbayraktar Z, Erbayraktar S, Yilmaz O et al. (2009) Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healing. Mol Med 15:235-41
13. Falanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet 366:1736-43 (Pubitemid 41587454)
14. Galeano M, Altavilla D, Bitto A et al. (2006) Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds. Crit Care Med 34:1139-46
15. Galeano M, Altavilla D, Cucinotta D et al. (2004) Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes 53:2509-17 (Pubitemid 39145612)
16. Grinnell F (1984) Fibronectin and wound healing. J Cell Biochem 26:107-16 (Pubitemid 15180965)
17. Hamed S, Ullmann Y, Masoud M et al. (2010) Topical erythropoietin promotes wound repair in diabetic rats. J Invest Dermatol 130:287-94
18. Haroon ZA, Amin K, Jiang X et al. (2003) A novel role for erythropoietin during fibrin-induced wound-healing response. Am J Pathol 63:993-1000 (Pubitemid 37040135)
19. Hehenberger K, Hansson A, Heilborn JD et al. (1999) Impaired proliferation and increased L-lactate production of dermal fibroblasts in the GK-rat, a spontaneous model of non-insulin dependent diabetes mellitus. Wound Repair Regen 7:65-71 (Pubitemid 29159042)
20. Isogai R, Takahashi M, Aisu K et al. (2006) The receptor for erythropoietin is present on cutaneous mast cells. Arch Dermatol Res 297:389-94 (Pubitemid 43288213)
21. Jarvis M, Schulz U, Dickinson AM et al. (2002) The detection of apoptosis in a human in vitro skin explant assay for graft versus host reactions. J Clin Pathol 55:127-32 (Pubitemid 34123914)
22. Kim EK, Hong JP (2007) The effect of recombinant human erythropoietin on ischemia-reperfusion injury: an experimental study in a rat TRAM flap model. Plast Reconstr Surg 120:1774-81 (Pubitemid 350306672)
23. Labat-Robert J, Leutenegger M, Llopis G et al. (1984) Plasma and tissue fibronectin in diabetes. Clin Physiol Biochem 2:39-48 (Pubitemid 14170221)
24. Li F, Chong ZZ, Maiese K (2004) Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways. Neurosignals 13:265-89 (Pubitemid 40073625)
25. Mansbridge JN, Liu K, Pinney RE et al. (1999) Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers. Diabetes Obes Metab 1:265-79
26. Marhoffer W, Stein M, Maeser E et al. (1992) Impairment of polymorpho-nuclear leukocyte function and metabolic control of diabetes. Diabetes Care 15:256-60
27. Martin P (1997) Wound healing - aiming for perfect skin regeneration. Science 276:75-81 (Pubitemid 27161246)
28. Mustoe T (2004) Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg 187:65S-70S (Pubitemid 38625990)
29. Nakano M, Satoh K, Fukumoto Y et al. (2007) Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res 100:662-9 (Pubitemid 46594880)
30. Pankov R, Yamada KM (2002) Fibronectin at a glance. J Cell Sci 115:3861-3 (Pubitemid 35256486)
31. Qiu Z, Kwon AH, Kamiyama Y (2007) Effects of plasma fibronectin on the healing of full-thickness skin wounds in streptozotocin-induced diabetic rats. J Surg Res 138:64-70 (Pubitemid 46227451)
32. Quinn JV (1998) Tissue Adhesives in Wound Care. B.C. Decker: Hamilton, ON Electronic book
33. Sayan H, Ozacmak VH, Guven A et al. (2006) Erythropoietin stimulates wound healing and angiogenesis in mice. J Invest Surg 19:163-73
34. Sheetz MJ, King GL (2002) Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 288:2579-88 (Pubitemid 35386893)
35. Shukla A, Dubey MP, Srivastava R et al. (1998) Differential expression of proteins during healing of cutaneous wounds in experimental normal and chronic models. Biochem Biophys Res Commun 244:434-9 (Pubitemid 28414100)
36. Snyder RJ (2005) Treatment of nonhealing ulcers with allografts. Clin Dermatol 23:388-95 (Pubitemid 40968111)
37. Sorg H, Krueger C, Schulz T et al. (2009) Effects of erythropoietin in skin wound healing are dose related. FASEB J 23:3049-58
38. Stadelmann WK, Digenis AG, Tobin GR (1998) Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176:26S-38S (Pubitemid 28460655)
39. Strunk T, Hartel C, Temming P et al. (2008) Erythropoietin inhibits cytokine production of neonatal and adult leukocytes. Acta Paediatr 97:16-20
40. Wang L, Chopp M, Gregg SR et al. (2008) Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF. J Cereb Blood Flow Metab 28:1361-8 (Pubitemid 351896653)
41. Westenbrink BD, Lipsic E, Van der Meer P et al. (2007) Erytharopoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization. Eur Heart J 28:2018-27 (Pubitemid 47579534)
42. Wysocki AB, Grinnell F (1990) Fibronectin profiles in normal and chronic wound fluid. Lab Invest 63:825-31
43. Yazihan N, Karakurt O, Ataoglu H (2008) Erythropoietin reduces lipopoly-saccharide-induced cell damage and midkine secretion in U937 human histiocytic lymphoma cells. Adv Ther 25:502-14