Preliminary study comparing the effects of locally and systemically app lied L-carnitine on the healing of full-thickness skin defects

Scandinavian Journal of Surgery

Volumn 99, Issue 3, 2010, Pages 147-152

  Karsidag, Tamer ^a   Asensio, J A ^b   Kabukcuoglu, F ^c   Tuzun, S ^a  

^a HASEKI EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c SISLI ETFAL TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Full thickness defect; L carnitine; Local; Secondary healing; Systemic; Wound healing

Indexed keywords

EID: 78649527939     PISSN: 14574969     EISSN: None     Source Type: Journal    
DOI: 10.1177/145749691009900309     Document Type: Article

References (21)

1. Koybasi S, Yilmaz T: The effect of L-Carnitine on wound healing by secondary intention in an animal model. Wounds 2005;17(3):62-66
2. Bohles H, Evangeliou A, Bervoets K, et al: Carnitine esters in metabolic disease. Eur J Pediatr 1994;367:57-61
3. Aslan E, Basterzi Y, Aksoy A, et al: The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats. Med Sci Monit 2005;11(6):BR176-180
4. Stumpf DA, Parker WD Jr, Angelini C: Carnitine deficiency, organic acidemias, and Reye's syndrome. Neurology 1985; 35(7):1041-1045
5. Clark RA: Cutaneous tissue repair: basic biologic consideration. I. J Am Acad Dermatol 1985;13:701-25
6. Scholar A, Stadelmann W: Wound healing: chronic wounds. Emedicine.com. Accessed December 27, 2006
7. Muller MJ, Hollyoak MA, Moaveni Z, et al: Retardation of wound healing by silver sulfadiazine is reversed by aloe vera and nystatin. Burns 2003;29(8):834-836
8. Martin P, Leibovich SJ: Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 2005; 15(11): 599-607
9. Greenhalgh DG: The role of apoptosis in wound healing. The International Journal of Biochemistry and Cell Biology 1998; 30(9):1019-1030
10. Fabriello RG, Calabrese F: Prevention of ischemia induced increase in MDA by acetyl carnitine. Ann Neurol 1988;24:114-118
11. Cetinkaya A, Bulbuloglu E, Kantarceken B, et al: Effects of Lcarnitine on oxidant/antioxidant status in acetic acid-induced colitis. Dig Dis Sci 2006;51(3): 488-494
12. Sener G, Paskaloglu K, Satiroglu H, et al: L-Carnitine meliorates oxidative damage due to chronic renal failure in rats. J Cardiovasc Pharmacol 2004;43:698-705
13. Gorur S, Bagdatoglu OT, Polat G: Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat. Cell Biochem Funct 2004;23:151-155
14. Arockia Rani PJ, Panneerselvam C: Carnitine as a free radical scavenger in aging. Exp Gerontol 2001;36:1713-1726
15. Demirdag K, Bahcecioglu IH, Ozercan IH, et al: Role of Lcarnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats. J Gastroenterol Hepatol 2004;19: 333-338
16. Caruso A, Cutuli VM, Bernardis E, et al: Protective effect of propionyl L-carnitine against PAF-induced rat paw oedema. Pharmacol Res 1995;31(1):67-72
17. Kumaran S, Deepak B, Naveen B, Panneerselvam C: Effects of levocarnitine on mitochondrial antioxidant systems and oxidative stress in aged rats. Drugs RD 2003;4:141-147
18. Kargi E, Deren O, Babuccu O, et al: Dual synergistic effect: the effect of dexamethasone plus carnitine on skin flap survival. Ann Plast Surg 2004;53:488-491
19. Persico G, Amato B, Aprea G, et al: The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriophatic patients: a controlled randomized study. Drugs Exp Clin Res 1995;21(5):187-198
20. Spagnoli LG, Palmieri G, Mauriello A, et al: Morphometric evidence of the trophic effect of L-carnitine on human skeletal muscle. Nephro 1990;55(1):16-23
21. Tellioglu AT, Uras KA, Yilmaz T, et al: The effect of carnitine on random-pattern flap survival in rats. Plast Reconstr Surg 2001;108(4):959-962