Morphological features of organelles during apoptosis: An overview

Cells

Volumn 2, Issue 2, 2013, Pages 294-305

  Bottone, Maria Grazia ^a,b   Santin, Giada ^a,b   Aredia, Francesca ^b   Bernocchi, Graziella ^a   Pellicciari, Carlo ^a   Scovassi, Anna Ivana ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b CNR   (Italy)

Author keywords

Apoptosis; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Lysosomes; Mitochondria

Indexed keywords

ACTIN; CISPLATIN; DACTINOMYCIN; HEAT SHOCK PROTEIN 70; RIBONUCLEOPROTEIN;

ANTIBODY LABELING; APOPTOSIS; CELL DEATH; CELL MEMBRANE; CELL ORGANELLE; CONFOCAL MICROSCOPY; CYTOSKELETON; DNA DEGRADATION; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; FLUORESCENCE MICROSCOPY; GOLGI COMPLEX; HELA CELL; HUMAN; IMMUNOCYTOCHEMISTRY; LYSOSOME; MICROTUBULE; MITOCHONDRION; MORPHOLOGICAL TRAIT; NEUROBLASTOMA CELL; REVIEW;

EID: 84900551341     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells2020294     Document Type: Review

References (46)

1. Joza, N.; Susin, S.A.; Daugas, E.; Stanford, W.L.; Cho, S.K.; Li, C.Y.; Sasaki, T.; Elia, A.J.; Cheng, H.Y.; Ravagnan, L.; et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 2001, 410, 549-554.
2. Le Bras, M.; Rouy, I.; Brenner, C. The modulation of inter-organelle cross-talk to control apoptosis. Med. Chem. 2006, 2, 1-12.
3. Soldani, C.; Bottone, M.G.; Fraschini, A.; Croce, A.C.; Bottiroli, G.; Scovassi, A.I.; Pellicciari, C. Apoptosis as a Consequence of Multiple Organelle Damage in Cultured Tumor Cells after Photosensitization with Rose Bengal Acetate. In Cell Apoptosis and Cancer; Taylor, A.W., Ed.; NOVA Science: Hauppauge, NY, USA, 2007; pp. 23-45.
4. Bottone, M.G.; Giansanti, V.; Veneroni, P.; Bernocchi, G.; Scovassi, A.I.; Pellicciari, C. The Apoptosis-Inducing Factor (AIF) Moves from Mitochondria to the Nucleus and Back to the Cytoplasm, during Apoptosis. In Mitochondria: Structure, Functions and Dysfunctions; Svensson, O.L., Ed.; NOVA Science: Hauppauge, NY, USA, 2010; pp. 123-140.
5. Santin, G.; Scietti, L.; Veneroni, P.; Barni, S.; Bernocchi, G.; Bottone, M.G. Effects of Cisplatin in neuroblastoma rat cells: damage to cellular organelles. Int. J. Cell Biol. 2012, 2012, 1-6.
6. Núñez, R.; Sancho-Martínez, S.M.; Novoa, J.M.; López-Hernández, F.J. Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies. Cell Death Differ. 2010, 17, 1665-1671.
7. Soldani, C.; Croce, A.C.; Bottone, M.G.; Fraschini, A.; Biggiogera, M.; Bottiroli, G.; Pellicciari, C. Apoptosis in tumour cells photosensitized with Rose Bengal acetate is induced by multiple organelle photodamage. Histochem. Cell Biol. 2007, 128, 485-495.
8. Grimm, S. The ER-mitochondria interface: the social network of cell death. Biochim. Biophys. Acta 2012, 1823, 327-334.
9. Fraschini, A.; Bottone, M.G.; Scovassi, A.I.; Denegri, M.; Risueño, M.C.; Testillano, P.S.; Martin, T.E.; Biggiogera, M.; Pellicciari, C. Changes in extranucleolar transcription during actinomycin D-induced apoptosis. Histol. Histopathol. 2005, 20, 107-117.
10. Jiang, Z.; Hu, Z.; Zeng, L.; Lu, W.; Zhang, H.; Li, T.; Xiao, H. The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria? Free Radic. Biol. Med. 2011, 50, 907-917.
11. Soldani, C.; Bottone, M.G.; Croce, A.C.; Fraschini, A.; Bottiroli, G.; Pellicciari, C. The Golgi apparatus is a primary site of intracellular damage after photosensitization with Rose Bengal acetate. Eur. J. Histochem. 2004, 48, 443-448.
12. Bottone, M.G.; Santin, G.; Soldani, C.; Veneroni, P.; Scovassi, A.I.; Alpini, C. Intracellular distribution of Tankyrases as detected by multicolor immunofluorescence techniques. Eur. J. Histochem. 2012, 56, e4.
13. Kurz, T.; Terman, A.; Gustafsson, B.; Brunk, U.T. Lysosomes in iron metabolism, ageing and apoptosis. Histochem. Cell Biol. 2008, 129, 389-406.
14. Kirkegaard, T.; Jäättelä, M. Lysosomal involvement in cell death and cancer. Biochim. Biophys. Acta 2009, 1793, 746-754.
15. Česen, M.H.; Pegan, K.; Spes, A.; Turk, B. Lysosomal pathways to cell death and their therapeutic applications. Exp. Cell Res. 2012, 318, 1245-1251.
16. Repnik, U.; Stoka, V.; Turk, V.; Turk, B. Lysosomes and lysosomal cathepsins in cell death. Biochim. Biophys. Acta 2012, 1824, 22-33.
17. Johansson, A.C.; Appelqvist, H.; Nilsson, C.; Kågedal, K.; Roberg, K.; Ollinger, K. Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis 2010, 15, 527-540.
18. Repnik, U.; Turk, B. Lysosomal-mitochondrial cross-talk during cell death. Mitochondrion 2010, 10, 662-669.
19. Schrader, K.; Huai, J.; Jöckel, L.; Oberle, C.; Borner, C. Non-caspase proteases: Triggers or amplifiers of apoptosis? Cell Mol. Life Sci. 2010, 67, 1607-1618.
20. Alpini, C.; Lotzniker, M.; Valaperta, S.; Bottone, M.G.; Malatesta, M.; Montanelli, A.; Merlini, G. Characterization for anti-cytoplasmic antibodies specificity by morphological and molecular techniques. Autoimmun. Highlights 2012, 3, 79-85.
21. Kroemer, G.; Petit, P.; Zamzami, N.; Vayssiere, J.L.; Mignotte, B. The biochemistry of programmed cell death. FASEB J. 1995, 9, 1277-1287.
22. Green, D.R.; Kroemer, G. The pathophysiology of mitochondrial cell death. Science 2004, 305, 626-629.
23. Giansanti, V.; Camboni, T.; Piscitelli, F.; Prosperi, E.; La Regina, G.; Lazzè, M.C.; Santin, G.; Silvestri, R.; Scovassi, A.I. Study of the effects of a new pyrazolecarboxamide: Changes in mitochondria and induction of apoptosis. Int. J. Biochem. Cell Biol. 2009, 41, 1890-1898.
24. Giansanti, V.; Villalpando Rodriguez, G.E.; Savoldelli, M.; Gioia, R.; Forlino, A.; Mazzini, G.; Pennati, M.; Zaffaroni, N.; Scovassi, A.I.; Torriglia, A. Characterization of stress response in human retinal epithelial cells. J. Cell. Mol. Med. 2013, 17, 103-115.
25. Kroemer, G.; Reed, J.C. Mitochondrial control of cell death. Nat. Med. 2000, 6, 513-519.
26. Lorenzo, H.K.; Susin, S.A.; Penninger, J.; Kroemer, G. Apoptosis inducing factor (AIF): A phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 1999, 6, 516-524.
27. Scovassi, A.I.; Soldani, C.; Veneroni, P.; Bottone, M.G.; Pellicciari, C. Changes of mitochondria and relocation of the Apoptosis-Inducing Factor during apoptosis. Ann. N.Y. Acad. Sci. 2009, 1171, 12-17.
28. Henson, P.M.; Hume, D.A. Apoptotic cell removal in development and tissue homeostasis. Trends Immunol. 2006, 27, 244-225.
29. Penaloza, C.; Lin, L.; Lockshin, R.A.; Zakeri, Z. Cell death in development: shaping the embryo. Histochem. Cell Biol. 2006, 126, 149-158.
30. Kerr, J.F.R.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239-257.
31. Biggiogera, M.; Bottone, M.G.; Pellicciari, C. Nuclear ribonucleoprotein-containing structures undergo severe rearrangement during spontaneous thymocyte apoptosis. A morphological study by electron microscopy. Histochem. Cell Biol. 1997, 107, 331-336.
32. Biggiogera, M.; Bottone, M.G.; Scovassi, A.I.; Soldani, C.; Vecchio, L.; Pellicciari, C. Rearrangement of nuclear ribonucleoprotein (RNP)-containing structures during apoptosis and transcriptional arrest. Biol. Cell 2004, 96, 603-615.
33. Biggiogera, M.; Pellicciari, C. Heterogeneous Ectopic RNP-Derived Structures (HERDS) are markers of transcriptional arrest. FASEB J. 2000, 14, 828-834.
34. May, R.C.; Machesky, L.M. Phagocytosis and the actin cytoskeleton. J. Cell. Sci. 2001, 114, 1061-1077.
35. Moss, D.K.; Lane, J.D. Microtubules: Forgotten players in the apoptotic execution phase. Trends Cell Biol. 2006, 16, 330-338.
36. Oropesa, M.; de la Mata, M.; Maraver, J.G.; Cordero, M.D.; Cotán, D.; Rodríguez-Hernández, A.; Domínguez-Moñino, I.; de Miguel, M.; Navas, P.; Sánchez-Alcázar, J.A. Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria. Apoptosis 2011, 16, 404-424.
37. Franklin-Tong, V.E.; Gourlay, C.W. A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals. Biochem. J. 2008, 413, 389-404.
38. Bottone, M.G.; Soldani, C.; Tognon, G.; Gorrini, C.; Lazzè, M.C.; Brison, O.; Ciomei, M.; Pellicciari, C.; Scovassi, A.I. Multiple effects of paclitaxel are modulated by a high c-myc amplification level. Exp. Cell Res. 2003, 290, 49-59.
39. Bottone, M.G.; Soldani, C.; Veneroni, P.; Avella, D.; Pisu, M.; Bernocchi, G. Cell proliferation, Apoptosis and mitochondrial damage in rat B50 neuronal cells after cisplatin treatment. Cell Prolif. 2008, 41, 506-520.
40. Oyadomari, S.; Araki, E.; Mori, M. Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Apoptosis 2002, 7, 335-345.
41. Rios, R.M.; Bornens, M. The Golgi apparatus at the cell centre. Curr. Opin. Cell Biol. 2003, 15, 60-66.
42. Machamer, C.E. Golgi disassembly in apoptosis: Cause or effect? Trends Cell Biol. 2003, 13, 279-281.
43. Lane, J.; Allan, V. Microtubule-based membrane movement. Biochim. Biophys. Acta 1998, 29, 27-55.
44. Lane, J.D.; Vergnolle, M.A.; Woodman, P.G.; Allan, V.J. Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150(Glued) stops dynein-dependent membrane motility. J. Cell Biol. 2001, 153, 1415-1426.
45. Suria, H.; Chau, L.A.; Negrou, E.; Kelvin, D.J.; Madrenas, J. Cytoskelet-aletal /et-aldisruption induces T cell apoptosis by a caspase-3-mediated mechanism. Life Sci. 1999, 65, 2697-2707.
46. Verhagen, A.M.; Ekert, P.G.; Pakusch, M.; Silke, J.; Connolly, L.M.; Reid, G.E.; Moritz, R.L.; Simpson, R.J.; Vaux, D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000, 102, 43-53.