Ethanol disrupts intestinal epithelial tight junction integrity through intracellular calcium-mediated Rho/ROCK activation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 306, Issue 8, 2014, Pages

  Elamin, Elhaseen ^a,b,c   Masclee, Ad ^a,b,c   Dekker, Jan ^a,d   Jonkers, Daisy ^a,b,c  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Caco 2; Ethanol; Inositol 1,4,5 triphosphate receptor; Intestinal epithelial barrier; Intracellular calcium; Rho kinase; Tight junction

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALCOHOL; BETA CATENIN; CALCIUM; CALCIUM ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; F ACTIN; FLUO 3; MYOSIN; RHO FACTOR; RHO KINASE; UVOMORULIN; XESTOSPONGIN C;

ARTICLE; CACO 2 CELL LINE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; FLUORESCENCE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; INTESTINE MUCOSA PERMEABILITY; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TIGHT JUNCTION;

CACO-2; ETHANOL; INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR; INTESTINAL EPITHELIAL BARRIER; INTRACELLULAR CALCIUM; RHO KINASE; TIGHT JUNCTION;

CACO-2 CELLS; CALCIUM; CELLS, CULTURED; CHELATING AGENTS; EGTAZIC ACID; ETHANOL; HUMANS; INTESTINAL MUCOSA; LIVER DISEASES, ALCOHOLIC; PERMEABILITY; PHOSPHORYLATION; RHO-ASSOCIATED KINASES; SOLVENTS; TIGHT JUNCTIONS;

EID: 84900545097     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00236.2013     Document Type: Article

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