Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Juuti Uusitalo, Kati ^a,b   Klunder, Leon J ^b   Sjollema, Klaas A ^b   Mackovicova, Katarina ^b   Ohgaki, Ryuichi ^b   Hoekstra, Dick ^b   Dekker, Jan ^a,c   van IJzendoorn, Sven C D ^a,b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADALUMIMAB; CASPASE; GAMMA INTERFERON; INFLIXIMAB; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TIGHT JUNCTION PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ADALIMUMAB; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL POLARITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MORPHOGENESIS; PROTEIN FUNCTION; THREE DIMENSIONAL CELL CULTURE; TIGHT JUNCTION; BIOLOGICAL MODEL; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; EXTRACELLULAR SPACE; INTESTINE; METABOLISM; METHODOLOGY; MITOSIS INDEX; PROTEIN TRANSPORT; ULTRASTRUCTURE;

ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; APOPTOSIS; CACO-2 CELLS; CELL CULTURE TECHNIQUES; CELL MEMBRANE PERMEABILITY; CELL POLARITY; EPITHELIAL CELLS; EXTRACELLULAR SPACE; HUMANS; INTERFERON-GAMMA; INTESTINES; MITOTIC INDEX; MODELS, BIOLOGICAL; MORPHOGENESIS; PROTEIN TRANSPORT; SUBCELLULAR FRACTIONS; TIGHT JUNCTIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051651480     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022967     Document Type: Article

References (35)

1. Radtke F, Clevers H, (2005) Self-renewal and cancer of the gut: two sides of a coin. Science 307: 1904-1909.
2. McGuckin MA, Eri R, Simms LA, Florin TH, Radford-Smith G, (2009) Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm Bowel Dis 15: 100-113.
3. Papadakis KA, Targan SR, (2000) Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 51: 289-298.
4. Sands BE, Kaplan GG, (2007) The role of TNFalpha in ulcerative colitis. J Clin Pharmacol 47: 930-941.
5. Carpenter HA, Talley NJ, (2000) The importance of clinicopathological correlation in the diagnosis of inflammatory conditions of the colon: histological patterns with clinical implications. Am J Gastroenterol 95: 878-896.
6. Turner JR, (2006) Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol 169: 1901-1909.
7. Bruewer M, Samarin S, Nusrat A, (2006) Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci 1072: 242-252.
8. Schulzke JD, Ploeger S, Amasheh M, Fromm A, Zeissig S, et al. (2009) Epithelial tight junctions in intestinal inflammation. Ann N Y Acad Sci 1165: 294-300.
9. Suenaert P, Bulteel V, Lemmens L, Noman M, Geypens B, et al. (2002) Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol 97: 2000-2004.
10. Halbleib JM, Nelson WJ, (2006) Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev 20: 3199-3214.
11. Schock F, Perrimon N, (2002) Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol 18: 463-493.
12. Yeaman C, Grindstaff KK, Nelson WJ, (1999) New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev 79: 73-98.
13. Bryant DM, Mostov KE, (2008) From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol 9: 887-901.
14. Reinsch S, Karsenti E, (1994) Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J Cell Biol 126: 1509-1526.
15. Fleming ES, Zajac M, Moschenross DM, Montrose DC, Rosenberg DW, et al. (2007) Planar spindle orientation and asymmetric cytokinesis in the mouse small intestine. J Histochem Cytochem 55: 1173-1180.
16. Jaffe AB, Kaji N, Durgan J, Hall A, (2008) Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J Cell Biol 183: 625-633.
17. Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ, (1995) The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol 6: 175-184.
18. Halttunen T, Marttinen A, Rantala I, Kainulainen H, Mäki M, (1996) Fibroblasts and transforming growth factor beta induce organization and differentiation of T84 human epithelial cells. Gastroenterology 111: 1252-1262.
19. O'Brien LE, Jou TS, Pollack AL, Zhang Q, Hansen SH, et al. (2001) Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly. Nat Cell Biol 3: 831-838.
20. Debnath J, Brugge JS, (2005) Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5: 675-688.
21. Ivanov AI, Hopkins AM, Brown GT, Gerner-Smidt K, Babbin BA, et al. (2008) Myosin II regulates the shape of three-dimensional intestinal epithelial cysts. J Cell Sci 121: 1803-1814.
22. Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, et al. (2010) TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling. J Cell Sci 123: 4145-4155.
23. Gitter AH, Bendfeldt K, Schulzke JD, Fromm M, (2000) Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J 14: 1749-1753.
24. Capaldo CT, Nusrat A, (2009) Cytokine regulation of tight junctions. Biochim Biophys Acta 1788: 864-871.
25. Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, et al. (2003) Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 171: 6164-6172.
26. Haouzi D, Baghdiguian S, Granier G, Travo P, Mangeat P, et al. (2005) Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling. J Cell Sci 118: 2763-2773.
27. Töyli M, Rosberg-Kulha L, Capra J, Vuoristo J, Eskelinen S, (2010) Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays. Lab Invest 90: 915-928.
28. Yu W, Datta A, Leroy P, O'Brien LE, Mak G, et al. (2005) Beta1-integrin orients epithelial polarity via Rac1 and laminin. Mol Biol Cell 16: 433-445.
29. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, et al. (2008) Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep 9: 923-929.
30. Mailleux AA, Overholtzer M, Brugge JS, (2008) Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 7: 57-62.
31. Melnick M, Chen H, Zhou Y, Jaskoll T, (2001) Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec 262: 318-330.
32. Debnath J, Muthuswamy SK, Brugge JS, (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30: 256-268.
33. Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Werb Z, et al. (2008) Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol 18: 507-513.
34. Bryant DM, Datta A, Rodríguez-Fraticelli AE, Peränen J, Martín-Belmonte F, et al. (2010) A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol 12: 1035-1045.
35. Datta A, Bryant DM, Mostov KE, (2011) Molecular regulation of lumen morphogenesis. Molecular regulation of lumen morphogenesis. Curr Biol 21: R126-136.