Intestinal lipid absorption and lipoprotein formation

Current Opinion in Lipidology

Volumn 25, Issue 3, 2014, Pages 200-206

  Hussain, M Mahmood ^a,b  

^a Downstate Health Sciences University   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cholesterol; chylomicron; intestine; lipid absorption; triglyceride

Indexed keywords

ABC TRANSPORTER A1; ALPHA TOCOPHEROL; CHOLESTEROL; CHYLOMICRON; FAT DROPLET; FATTY ACID; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; LIVER X RECEPTOR AGONIST; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PHOSPHOLIPID; RETINOL; TRIACYLGLYCEROL; CARRIER PROTEIN; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR;

ATHEROSCLEROSIS; CYTOPLASM; ENDOPLASMIC RETICULUM; FAT INTAKE; HUMAN; HYPERLIPIDEMIA; INSULIN RESISTANCE; INTESTINE ABSORPTION; INTESTINE CELL; LIPID ABSORPTION; LIPID HYDROLYSIS; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STEATOSIS; UPREGULATION; ACTIVE TRANSPORT; ANIMAL; GENETICS; LIPID METABOLISM; METABOLISM; PHYSIOLOGY;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; HUMANS; INTESTINAL ABSORPTION; LIPID METABOLISM; LIPOPROTEINS; ORPHAN NUCLEAR RECEPTORS;

EID: 84900532524     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0000000000000084     Document Type: Review

References (54)

1. Mu H, Hoy CE. The digestion of dietary triacylglycerols. Prog Lipid Res 2004; 43:105-133.
2. Phan CT, Tso P. In testinal lipid absorption and transport. Front Biosci 2001; 6:D299-D319.
3. Iqbal J, Hussain MM. Intestinal lipid absorption. Am J Physiol Endocrinol Metab 2009; 296:E1183-E1194. 4. Pan X, Hussain MM. Gut triglyceride production. Biochim Biophys Acta 2012; 1821:727-735.
4. Pan X, Hussain MM. Gut triglyceride production. Biochim Biophys Acta 2012; 1821:727-735.
5. Abumrad NA, Davidson NO. Role of the gut in lipid homeostasis. Physiol Rev 2012; 92:1061-1085.
6. Abumrad N, Harmon C, Ibrahimi A. Membrane transport of long-chain fatty acids: Evidence for a facilitated process. J Lipid Res 1998; 39:2309-2318.
7. Storch J, Thumser AE. Tissue-specific functions in the fatty acid-binding protein family. J Biol Chem 2010; 285:32679-32683.
8. Mansbach CM, Siddiqi SA. The biogenesis of chylomicrons. Annu Rev Physiol 2010; 72:315-333.
9. Davis HR Jr, Tershakovec AM, Tomassini JE, Musliner T. Intestinal sterol transporters and cholesterol absorption inhibition. Curr Opin Lipidol 2011; 22:467-478.
10. Wang LJ, Song BL. Niemann-Pick C1-Like 1 and cholesterol uptake. Biochim Biophys Acta 2012; 1821:964-972.
11. Li PS, Fu ZY, Zhang YY, et al. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nat Med 2014; 20:80-86.
12. Hussain MM, Leung TM, Zhou L, Abu-Merhi S. Regulating intestinal function to reduce atherogenic lipoproteins. Clin Lipidol 2013; 8:481-490.
13. Thiam AR, Farese RV Jr, Walther TC. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol 2013; 14:775-786.
14. Demignot S, Beilstein F, Morel E. Triglyceride-rich lipoproteins and cytosolic lipid droplets in enterocytes: Key players in intestinal physiology and metabolic disorders. Biochimie 2014; 96:48-55.
15. Lehner R, Lian J, Quiroga AD. Lumenal lipid metabolism: Implications for lipoprotein assembly. Arterioscler Thromb Vasc Biol 2012; 32:1087-1093. 16. Martin S, Parton RG. Lipid droplets: A unified view of a dynamic organelle. Nat Rev Mol Cell Biol 2006; 7:373-378.
16. Martin S, Parton RG. Lipid droplets: A unified view of a dynamic organelle. Nat Rev Mol Cell Biol 2006; 7:373-378.
17. Murphy DJ, Vance J. Mechanisms of lipid body formation. Trends Biochem Sci 1999; 24:109-115.
18. Ohsaki Y, Cheng J, Suzuki M, et al. Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structur e. Biochim Biophys Acta 2009; 1791:399-407.
19. Sturley SL,Hussain MM. Lipid droplet formation on opposing sides of the endoplasmic reticulum. J Lipid Res, 2012, 53, 1800-1810.
20. Lambert JE, Parks EJ. Postprandial metabolism of meal triglyceride in humans. Biochim Biophys Acta 2012; 1821:721-726.
21. Hamilton RL, Wong JS, Cham CM, et al. Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency. J Lipid Res 1998; 39:1543-1557.
22. Raabe M, Ve ́ niant MM, Sullivan MA, et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest 1999; 103:1287-1298.
23. Kulinski A, Rustaeus S, Vance JE. Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with Apo B, as well as for Apo B lipidation. J Biol Chem 2002; 277:31516-31525.
24. Wang Y, Tran K, Yao Z. The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McARH7777 cells. A unified model for the assembly of very low density lipoproteins. J Bi ol Chem 1999; 274:27793-27800.
25. Hussain MM, Rava P, Walsh M, et al. Multiple functions of microsomal triglyceride transfer protein. Nutr Metab (Lond) 2012; 9:14.
26. Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apolipoprotein B-lipoprotein assembly. J Lipid Res 2003; 44:22-32.
27. Hussain MM, Kancha RK, Zhou Z, et al. Chylomicron assembly and catabolism: Role of apolipoproteins and receptors. Biochim Biophys Acta 1996; 1300:151-170.
28. Jiang ZG, Liu Y, Hussain MM, et al. Reconstitut ing initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system. J Mol Biol 2008; 383:1181-1194.
29. Hussain MM. A proposed model for the assembly of chylomicrons. Atherosclerosis 2000; 148:1-15.
30. Luchoomun J, Hussain MM. Assembly and secretion of chylomicrons by differentiated Caco-2 cells: Nascent triglycerides and preformed phospholipids are preferentially used for lipoprotein assembly. J Biol Chem 1999; 274:19565-19572.
31. Kumar NS, Mansbach CM. II. Prechylomicron transport vesicle: Isolation and partial characterization. Am J Physiol Gastrointest Liver Physiol 1999; 276: G378-G386.
32. Mansbach CM, Gorelick F. Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons. Am J Physiol Gastrointest Liver Phys iol 2007; 293:G645-G650.
33. Black DD. Development and physiological regulation of intestinal lipid absorption. I. Development of intestinal lipid absorption: Cellular events in chylomicron assembly and secre tion. Am J Physiol Gastrointest Liver Physiol 2007; 293:G519-G524.
34. Siddiqi SA, Mahan J, Siddiqi S, et al. Vesicle-associated membrane protein 7 is expressed in intestinal ER. J Cell Sci 2006; 119:943-950.
35. Neeli I, Siddiqi SA, Sidd iqi S, et al. Liver fatty acid-binding protein initiates budding of prechylomicron transport vesicles from intestinal endoplasmic reticulum. J Biol Chem 2007; 282:17974-17984.
36. Siddiqi SA, Mansbac h CM. PKC zeta-mediated phosphorylation controls budding of the prechylomicron transport vesicle. J Cell Sci 2008; 121:2327-2338.
37. Siddiqi S, Saleem U, Abumrad NA, et al. A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. J Lipid Res 2010; 51:1918 -1928.
38. Iqbal J, Anwar K, Hussain MM. Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells. J Biol Chem 2003; 278:31610-31620.
39. Williams KJ. Molecular processes that handle-and mishandle-dietary lipids. J Clin Invest 2008; 118:3247-3259.
40. Iqbal J, Hussain MM. Evidence for multiple complementary pathways for efficient cholesterol absorption in mice. J Lipid Res 2005; 46:1491-1501.
41. Repa JJ,Turley SD,Lobaccaro JA,et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science, 2000, 289, 1524-1529.
42. Zha X, Gauthier A, Genest J, McPherson R. Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1) mediated cholesterol efflux. J Biol Chem 2003; 278:10002-10005.
43. Brunham LR, Kruit JK, Iqbal J, et al. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 2006; 116:1052-1062.
44. Temel RE, Lee RG, Kelley KL, et al. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. J Lipid Res 2005; 46:2423-2431.
45. Iqbal J, Parks JS, Hussain MM. Lipid absorption defects in intestine -specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice. J Biol Chem 2013; 288:30432-30444.
46. Xiao C, Lewis GF. Regulation of chylomicron production in humans. Biochim Biophys Acta 2012; 1821:736-746.
47. Veilleux A, Grenier E, Marceau P, et al. Intestinal lipid handling: Evidence and implication of insulin signaling abnormalities in human obese subjects. Arterioscler Thromb Vasc Biol 2014; 34:644-653.
48. Couture P, Tremblay AJ, Kelly I, et a l. Key intestinal genes involved in lipoprotein metabolism are downregulated in dyslipidemic men with insulin resistance. J Lipid Res 2014; 55:128-137. The authors show that insulin-resistant men produce more triglyceride-rich a poB48-containing lipoproteins.
49. Harrison EH, Hussain MM. Mechanisms involved in the intestinal digestion and absorption of dietary vitamin A. J Nutr 2001; 131:1405-1408.
50. Harr ison EH. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochim Biophys Acta 2012; 1821:70-77.
51. Reboul E, Borel P. Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes. Prog Lipid Res 2011; 50:388-402.
52. Anwar K, Kayden HJ, Hussain MM. Transport of vitamin E by differentiated Caco-2 cells. J Lipid Res 2006; 47:1261-1273.
53. Nicod N, Parker RS. Vitamin E secretion by Caco-2 monolayers to APOA1, but not to HDL, is vitamer selective. J Nutr 2013; 143:1565-1572.
54. Anwar K, Iqbal J, Hussain MM. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J Lipid Res 2007; 48:2028-2038.