Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation

American Journal of Physiology - Renal Physiology

Volumn 306, Issue 7, 2014, Pages

  Ikeda, Shoko ^a   Yamamoto, Hironori ^b,c   Masuda, Masashi ^a   Takei, Yuichiro ^a   Nakahashi, Otoki ^a   Kozai, Mina ^a   Tanaka, Sarasa ^a   Nakao, Mari ^a   Taketani, Yutaka ^a   Segawa, Hiroko ^a   Iwano, Masayuki ^c   Miyamoto, Ken Ichi ^a   Takeda, Eiji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b JIN AI UNIVERSITY   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

Kidney; LPS; Npt2a; Phosphate; PTH

Indexed keywords

CALCIUM ION; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FIBROBLAST GROWTH FACTOR 23; MESSENGER RNA; PARATHYROID HORMONE; PHOSPHATE; SODIUM PHOSPHATE COTRANSPORTER 2A; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CALCIUM URINE LEVEL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; INFLAMMATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROIDECTOMY; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PHOSPHATE URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

KIDNEY; LPS; NPT2A; PHOSPHATE; PTH;

ACUTE DISEASE; ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FIBROBLAST GROWTH FACTORS; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; KIDNEY; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICROVILLI; PARATHYROID HORMONE; PARATHYROIDECTOMY; PHOSPHATES; RATS; RATS, WISTAR; RNA, MESSENGER; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN D;

EID: 84900526385     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00474.2013     Document Type: Article

References (49)

1. Abu-Amer Y, Ross FP, Edwards J, Teitelbaum SL. Lipopolysaccharide- stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. J Clin Invest 100: 1557-1565, 1997.
2. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 4: 80-90, 2008.
3. Barak V, Schwartz A, Kalickman I, Nisman B, Gurman G, Shoenfeld Y. Prevalence of hypophosphatemia in sepsis and infection: the role of cytokines. Am J Med 104: 40-47, 1998.
4. Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HA, Hsieh JC, Slater SA, Hsieh G, Kaczmarska M, Jurutka PW, Kolek OI, Ghishan FK, Haussler MR. 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol 103: 381-388, 2007.
5. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 95: 5372-5377, 1998.
6. Biber J, Hernando N, Forster I, Murer H. Regulation of phosphate transport in proximal tubules. Pflügers Arch 458: 39-52, 2009.
7. Burnett-Bowie SM, Henao MP, Dere ME, Lee H, Leder BZ. Effects of hPTH(1-34) infusion on circulating serum phosphate, 1,25-dihydroxyvitamin D, and FGF23 levels in healthy men. J Bone Miner Res 24: 1681-1685, 2009.
8. Carlstedt F, Lind L, Rastad J, Stjernström H, Wide L, Ljunghall S. Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients. Eur J Clin Invest 28: 898-903, 1998.
9. El-Achkar TM, Huang X, Plotkin Z, Sandoval RM, Rhodes GJ, Dagher PC. Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney. Am J Physiol Renal Physiol 290: F1034-F1043, 2006.
10. Farrow EG, White KE. Recent advances in renal phosphate handling. Nat Rev Nephrol 6: 207-217, 2010.
11. Ferrari SL, Bonjour JP, Rizzoli R. Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J Clin Endocrinol Metab 90: 1519-1524, 2005.
12. Fukagawa M, Nii-Kono T, Kazama JJ. Role of fibroblast growth factor 23 in health and in chronic kidney disease. Curr OPin Nephrol Hypertens 14: 325-329, 2005.
13. Funk JL, Moser AH, Strewler GJ, Feingold KR, Grünfeld C. Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents. Mol Med 2: 204-210, 1996.
14. Gardella TJ, Jüppner H. Molecular properties of the PTH/PTHrP receptor. Trends Endocrinol Metab 12: 210-217, 2001.
15. Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate cotransporter (Npt2a) gene. Biochem J 427: 161-169, 2010.
16. Katai K, Segawa H, Haga H, Morita K, Arai H, Tatsumi S, Taketani Y, Miyamoto K, Hisano S, Fukui Y, Takeda E. Acute regulation by dietary phosphate of the sodium-dependent phosphate transporter [NaP(i)-2] in rat kidney. J Biochem 121: 50-55, 1997.
17. Kempson SA, Lötscher M, Kaissling B, Biber J, Murer H, Levi M. Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules. Am J Physiol Renal Fluid Electrolyte Physiol 268: F784-F791, 1995.
18. Kolek OI, Hines ER, Jones MD, LeSueur LK, Lipko MA, Kiela PR, Collins JF, Haussler MR, Ghishan FK. 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renalgastrointestinal- skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 289: G1036-G1042, 2005.
19. Kumar R, Thompson JR. The regulation of parathyroid hormone secretion and synthesis. J Am Soc Nephrol 22: 216-224, 2011.
20. + transporters in kidneys of rats with ischemiainduced acute renal failure. Am J Physiol Renal Physiol 278: F925-F939, 2000.
21. 2+ handling. Kidney Int 69: 650-654, 2006.
22. Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol 299: F882-F889, 2010.
23. Li C, Wang W, Kwon TH, Knepper MA, Nielsen S, Frøkiaer J. Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction. Am J Physiol Renal Physiol 284: F155-F166, 2003.
24. Lind L, Carlstedt F, Rastad J, Stiernström H, Stridsberg M, Ljunggren O, Wide L, Larsson A, Hellman P, Ljunghall S. Hypocalcemia and parathyroid hormone secretion in critically ill patients. Crit Care Med 28: 93-99, 2000.
25. Masuda M, Yamamoto H, Kozai M, Tanaka S, Ishiguro M, Takei Y, Nakahashi O, Ikeda S, Uebanso T, Taketani Y, Segawa H, Miyamoto K, Takeda E. Regulation of renal sodium-dependent phosphate cotransporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors. Biochem J 429: 583-592, 2010.
26. Murer H, Forster I, Biber J. The sodium phosphate cotransporter family SLC34. Pflügers Arch 447: 763-767, 2004.
27. Nakamura T, Mimura Y, Uno K, Yamakawa M. Parathyroid hormone activity increases during endotoxemia in conscious rats. Horm Metab Res 30: 88-92, 1998.
28. Nashiki K, Taketani Y, Takeichi T, Sawada N, Yamamoto H, Ichikawa M, Arai H, Miyamoto K, Takeda E. Role of membrane microdomains in PTH-mediated downregulation of NaPi-IIa in opossum kidney cells. Kidney Int 68: 1137-1147, 2005.
29. Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Taniguchi A, Sato T, Shuto E, Nashiki K, Arai H, Yamamoto H, Takeda E. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int 70: 2141-2147, 2006.
30. Pramanik R, Asplin JR, Lindeman C, Favus MJ, Bai S, Coe FL. Lipopolysaccharide negatively modulates vitamin D action by downregulating expression of vitamin D-induced VDR in human monocytic THP-1 cells. Cell Immunol 232: 137-143, 2004.
31. Pålsson-McDermott EM, O'Neill LA. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113: 153-162, 2004.
32. Ramesh G, Reeves WB. TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. Am J Physiol Renal Physiol 285: F610-F618, 2003.
33. Rodrigues CE, Sanches TR, VolPini RA, Shimizu MH, Kuriki PS, Camara NO, Seguro AC, Andrade L. Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multiorgan dysfunction. PLoS One 7: e29893, 2012.
34. +-dependent phosphate cotransport activity and 1alpha,25- dihydroxyvitamin D3 production. J Biol Chem 278: 2206-2211, 2003.
35. 2+. Arch Surg 135: 1432-1442, 2000.
36. Segawa H, Aranami F, Kaneko I, Tomoe Y, Miyamoto K. The roles of Na/Pi-II transporters in phosphate metabolism. Bone 45, Suppl 1: S2-7, 2009.
37. Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K. Growth-related renal type II Na/Pi cotransporter. J Biol Chem 277: 19665-19672, 2002.
38. Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol 297: F671-F678, 2009.
39. Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, Miyamoto K. Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter. Am J Physiol Renal Physiol 292: F395-F403, 2007.
40. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, Yamashita T. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 19: 429-435, 2004.
41. Shor R, Halabe A, Rishver S, Tilis Y, Matas Z, Fux A, Boaz M, Weinstein J. Severe hypophosphatemia in sepsis as a mortality predictor. Ann Clin Lab Sci 36: 67-72, 2006.
42. Takeda E, Taketani Y, Sawada N, Sato T, Yamamoto H. The regulation and function of phosphate in the human body. Biofactors 21: 345-355, 2004.
43. +-dependent inorganic phosphate transporters by 1,25-dihydroxyvitamin D3. Identification of a vitamin D-responsive element in the human NAPi-3 gene. J Biol Chem 273: 14575-14581, 1998.
44. +-Pi cotransporter PiT-2 (SLC20A2) is expressed in the aPical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol 296: F691-F699, 2009.
45. Wu L, Tiwari MM, Messer KJ, Holthoff JH, Gokden N, Brock RW, Mayeux PR. Peritubular caPillary dysfunction and renal tubular ePithelial cell stress following lipopolysaccharide administration in mice. Am J Physiol Renal Physiol 292: F261-F268, 2007.
46. Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E. Alternative promoters and renal cell-specific regulation of the mouse type IIa sodiumdependent phosphate cotransporter gene. Biochim Biophys Acta 1732: 43-52, 2005.
47. Zehnder D, Bland R, Chana RS, Wheeler DC, Howie AJ, Williams MC, Stewart PM, Hewison M. Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol 13: 621-629, 2002.
48. Zikan V, Stepan JJ. Marker of bone resorption in acute response to exogenous or endogenous parathyroid hormone. Biomark Insights 3: 19-24, 2008.
49. Zivin JR, Gooley T, Zager RA, Ryan MJ. Hypocalcemia: a pervasive metabolic abnormality in the critically ill. Am J Kidney Dis 37: 689-698, 2001.