Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors

Biochemical Journal

Volumn 429, Issue 3, 2010, Pages 583-592

  Masuda, Masashi ^a   Yamamoto, Hironori ^a   Kozai, Mina ^a   Tanaka, Sarasa ^a   Ishiguro, Mariko ^a   Takei, Yuichiro ^a   Nakahashi, Otoki ^a   Ikeda, Shoko ^a   Uebanso, Takashi ^a   Taketani, Yutaka ^a   Segawa, Hiroko ^a   Miyamoto, Ken Ichi ^a   Takeda, Eiji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

All trans retinoic acid (ATRA); Gene promoter analysis; Phosphate homoeostasis; Renal type II sodium dependent phosphate co transporter (Npt); Retinoic acid nuclear receptor; Vitamin A

Indexed keywords

ALL-TRANS RETINOIC ACIDS; GENE PROMOTER ANALYSIS; PHOSPHATE HOMOEOSTASIS; RENAL TYPE II SODIUM-DEPENDENT PHOSPHATE CO-TRANSPORTER (NPT); RETINOIC ACIDS; VITAMIN A;

ACIDS; BODY FLUIDS; CELL PROLIFERATION; GENE EXPRESSION; PHYSIOLOGY; RATS; SODIUM;

GENE EXPRESSION REGULATION;

4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 1 PROPENYL]BENZOIC ACID; CALCITRIOL; LUCIFERASE; PHOSPHORUS; RETINOIC ACID; RETINOIC ACID RECEPTOR; DRUG RECEPTOR; NPT2 PROTEIN, RAT; SODIUM PHOSPHATE COTRANSPORTER 2A;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE; GENETIC TRANSCRIPTION; HOMEOSTASIS; HUMAN; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; NPT2A GENE; NPT2C GENE; PHOSPHATE BLOOD LEVEL; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; RETINOL DEFICIENCY; STATISTICAL SIGNIFICANCE; URINARY EXCRETION; VITAMIN D RESPONSIVE ELEMENT; ANIMAL; DIET; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

RATTUS; TETRA;

ANIMALS; BLOTTING, WESTERN; DIET; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; KIDNEY; MALE; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RECEPTORS, DRUG; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA; TRANSCRIPTION, GENETIC; TRETINOIN;

EID: 77955067370     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100484     Document Type: Article

References (40)

1. Murer, H., Hernando, N., Forster, I. and Biber, J. (2000) Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol. Rev. 80, 1373-1409
2. Takeda, E., Yamamoto, H., Nashiki, K., Sato, T., Arai, H. and Taketani, Y. (2004) Inorganic phosphate homeostasis and the role of dietary phosphorus. J. Cell. Mol. Med. 8, 191-200
3. Verri, T., Markovich, D., Perego, C., Norbis, F., Stange, G., Sorribas, V., Biber, J. and Murer, H. (1995) Cloning of a rabbit renal Na-Pi cotransporter, which is regulated by dietary phosphate. Am. J. Physiol. Renal Physiol. 268, F626-F633
4. Busch, A. E., Schuster, A., Waldegger, S., Wagner, C. A., Zempel, G., Broer, S., Biber, J., Murer, H. and Lang, F. (1996) Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopusoocytes permeable for organic and inorganic anions. Proc. Natl. Acad. Sci. U.S.A. 93, 5347-5351
5. Kavanaugh, M. P., Miller, D. G., Zhang, W., Law, W., Kozak, S. L., Kabat, D. and Miller, A. D. (1994) Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc. Natl. Acad. Sci. U.S.A. 91, 7071-7075
6. +-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am. J. Physiol. Renal Physiol. 296, F691-F699
7. Breusegem, S. Y., Takahashi, H., Giral-Arnal, H., Wang, X., Jiang, T., Verlander, J. W., Wilson, P., Miyazaki-Anzai, S., Sutherland, E., Caldas, Y. et al. (2009) Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am. J. Physiol. Renal Physiol. 297, F350-F361
8. Miyamoto, K., Ito, M., Tatsumi, S., Kuwahata, M. and Segawa, H. (2007) New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter. Am. J. Nephrol. 27, 503-515
9. Segawa, H., Onitsuka, A., Furutani, J., Kaneko, I., Aranami, F., Matsumoto, N., Tomoe, Y., Kuwahata, M., Ito, M., Matsumoto, M. et al. (2009) Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am. J. Physiol. Renal Physiol. 297, F671-F678
10. Segawa, H., Kaneko, I., Takahashi, A., Kuwahata, M., Ito, M., Ohkido, I., Tatsumi, S. and Miyamoto, K. (2002) Growth-related renal type II Na/Pi cotransporter. J. Biol. Chem. 277, 19665-19672
11. Bergwitz, C., Roslin, N. M., Tieder, M., Loredo-Osti, J. C., Bastepe, M., Abu-Zahra, H., Frappier, D., Burkett, K., Carpenter, T. O., Anderson, D. et al. (2006) SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Am. J. Hum. Genet. 78, 179-192
12. Lorenz-Depiereux, B., Benet-Pages, A., Eckstein, G., Tenenbaum-Rakover, Y., Wagenstaller, J., Tiosano, D., Gershoni-Baruch, R., Albers, N., Lichtner, P., Schnabel, D. et al. (2006) Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Am. J. Hum. Genet. 78, 193-201
13. Ohkido, I., Segawa, H., Yanagida, R., Nakamura, M. and Miyamoto, K. (2003) Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney. Pflugers Arch. 446, 106-115
14. Nashiki, K., Taketani, Y., Takeichi, T., Sawada, N., Yamamoto, H., Ichikawa, M., Arai, H., Miyamoto, K. and Takeda, E. (2005) Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells. Kidney Int. 68, 1137-1147 (Pubitemid 43246430)
15. Segawa, H., Yamanaka, S., Onitsuka, A., Tomoe, Y., Kuwahata, M., Ito, M., Taketani, Y. and Miyamoto, K. (2007) Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter. Am. J. Physiol. Renal Physiol. 292, F395-F403
16. Segawa, H., Kawakami, E., Kaneko, I., Kuwahata, M., Ito, M., Kusano, K., Saito, H., Fukushima, N. and Miyamoto, K. (2003) Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter. Pflugers Arch. 446, 585-592
17. Inoue, Y., Segawa, H., Kaneko, I., Yamanaka, S., Kusano, K., Kawakami, E., Furutani, J., Ito, M., Kuwahata, M., Saito, H. et al. (2005) Role of the vitamin D receptor in FGF23 action on phosphate metabolism. Biochem. J. 390, 325-331
18. Segawa, H., Kaneko, I., Yamanaka, S., Ito, M., Kuwahata, M., Inoue, Y., Kato, S. and Miyamoto, K. (2004) Intestinal Na-Pi cotransporter adaption to dietary Pi content in vitamin D receptor null mice. Am. J. Physiol. Renal Physiol. 287, F39-F47
19. Ishiguro, M., Yamamoto, H., Masuda, M., Kozai, M., Takei, Y., Sato, T., Segawa, H., Taketani, Y., Arai, H., Miyamoto, K. and Takeda, E. (2010) Thyroid hormones regulate phosphate homeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter ( Npt2a) gene. Biochem. J. 427, 161-169
20. +-dependent cotransporters by retinoic acid in opossum kidney cells. Am. J. Physiol. Renal Physiol. 273, F438-F444
21. Nerurkar, M. K. and Sahasrabudhe, M. B. (1956) Metabolism of calcium, phosphorus and nitrogen in hypervitaminosis A in young rats. Biochem. J. 63, 344-349
22. Frankel, T. L., Seshadri, M. S., McDowall, D. B. and Cornish, C. J. (1986) Hypervitaminosis A and calcium-regulating hormones in the rat. J. Nutr. 116, 578-587
23. Hough, S., Avioli, L. V., Muir, H., Gelderblom, D., Jenkins, G., Kurasi, H., Slatopolsky, E., Bergfeld, M. A. and Teitelbaum, S. L. (1988) Effects of hypervitaminosis A on the bone and mineral metabolism of the rat. Endocrinology 122, 2933-2939
24. Ross, S. A., McCaffery, P. J., Drager, U. C. and De Luca, L. M. (2000) Retinoids in embryonal development. Physiol. Rev. 80, 1021-1054
25. De Luca, L. M. (1991) Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J. 5, 2924-2933
26. Stephensen, C. B. (2001) Vitamin A, infection, and immune function. Annu. Rev. Nutr. 21, 167-192
27. Chambon, P. (1996) A decade of molecular biology of retinoic acid receptors. FASEB J. 10, 940-954 (Pubitemid 26285969)
28. Mangelsdorf, D. J. and Evans, R. M. (1995) The RXR heterodimers and orphan receptors. Cell 83, 841-850
29. Bastien, J. and Rochette-Egly, C. (2004) Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 328, 1-16
30. 3. J. Biol. Chem. 273, 14575-14581
31. +/phosphate co-transporter. Biochem. J. 324, 927-934
32. Schreiber, E., Matthias, P., Müller, M. and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419
33. Pignatello, M. A., Kauffman, F. C. and Levin, A. A. (1997) Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol. Appl. Pharmacol. 142, 319-327
34. Barthel, T. K., Mathern, D. R., Whitfield, G. K., Haussler, C. A., Hopper, 4th, H. A., Hsieh, J. C., Slater, S. A., Hsieh, G., Kaczmarska, M., Jurutka, P. W. et al. (2007) 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J. Steroid Biochem. Mol. Biol. 103, 381-388
35. Webb, Jr, K. E., Mitchell, Jr, G. E., Little, C. O. and Schmitt, G. H. (1968) Polyuria in vitamin A-deficient sheep. J. Anim. Sci. 27, 1657-1662
36. Sabbagh, Y., O'Brien, S., Song, W., Boulanger, J., Stockmann, A., Arbeeny, C. and Schiavi, S. (2009) Intestinal npt2b plays a major role in phosphate absorption and homeostasis. J. Am. Soc. Nephrol. 20, 2348-2358
37. Yamamoto, H., Tani, Y., Kobayashi, K., Taketani, Y., Sato, T., Arai, H., Morita, K., Miyamoto, K., Pike, J. W., Kato, S. and Takeda, E. (2005) Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene. Biochim. Biophys. Acta 1732, 43-52
38. 3 alters retinoic acid metabolism in vivo. Arch. Biochem. Biophys. 368, 244-248
39. Rohde, C. M. and DeLuca, H. F. (2005) All- trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecalciferol, in rats. J. Nutr. 135, 1647-1652
40. Wang, K., Chen, S., Xie, W. and Wan, Y. (2008) Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway. Biochem. Pharmacol. 75, 2204-2213