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Volumn 159, Issue 3-4, 2014, Pages 166-170

Chronic immune stimulation in adipose tissue and its consequences for health and performance in the pig

Author keywords

Pigs adipose inflammation

Indexed keywords

ADIPONECTIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; PATTERN RECOGNITION RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SATURATED FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; ADIPOCYTOKINE; FAT INTAKE; INFLAMMASOME;

EID: 84900515575     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2014.02.013     Document Type: Article
Times cited : (4)

References (52)
  • 1
    • 1342267442 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-γ in primary pig adipocytes
    • Ajuwon K.M., Jacobi S.K., Kuske J.L., Spurlock M.E. Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-γ in primary pig adipocytes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286:R547-R553.
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Ajuwon, K.M.1    Jacobi, S.K.2    Kuske, J.L.3    Spurlock, M.E.4
  • 2
    • 0141992039 scopus 로고    scopus 로고
    • Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue
    • Ajuwon K.M., Kuske J.L., Anderson D.B., Hancock D.L., Houseknecht K.L., Adeola O., Spurlock M.E. Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue. J. Nutr. Biochem. 2003, 14:576-583.
    • (2003) J. Nutr. Biochem. , vol.14 , pp. 576-583
    • Ajuwon, K.M.1    Kuske, J.L.2    Anderson, D.B.3    Hancock, D.L.4    Houseknecht, K.L.5    Adeola, O.6    Spurlock, M.E.7
  • 3
    • 23244450956 scopus 로고    scopus 로고
    • Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNF alpha expression in 3T3-L1 adipocytes
    • Ajuwon K.M., Spurlock M.E. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNF alpha expression in 3T3-L1 adipocytes. J. Nutr. 2005, 135:1841-1846.
    • (2005) J. Nutr. , vol.135 , pp. 1841-1846
    • Ajuwon, K.M.1    Spurlock, M.E.2
  • 4
    • 65349188130 scopus 로고    scopus 로고
    • Stimulation with peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes
    • Ajuwon K.M., Banz W., Winters T.A. Stimulation with peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes. J. Inflamm. (Lond.) 2009, 6:8. 10.1186/1476-9255-6-8.
    • (2009) J. Inflamm. (Lond.) , vol.6 , pp. 8
    • Ajuwon, K.M.1    Banz, W.2    Winters, T.A.3
  • 7
    • 78149443851 scopus 로고    scopus 로고
    • Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells
    • Bhatnagar S., Panguluri S.K., Gupta S.K., Dahiya S., Lundy R.F., Kumar A. Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells. PLoS ONE 2010, 5:e13262.
    • (2010) PLoS ONE , vol.5
    • Bhatnagar, S.1    Panguluri, S.K.2    Gupta, S.K.3    Dahiya, S.4    Lundy, R.F.5    Kumar, A.6
  • 8
    • 42949150111 scopus 로고    scopus 로고
    • Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes
    • Bradley R.L., Fisher F.F., Maratos-Flier E. Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes. Obesity (Silver Spring) 2008, 16:938-944.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 938-944
    • Bradley, R.L.1    Fisher, F.F.2    Maratos-Flier, E.3
  • 9
    • 84882582020 scopus 로고    scopus 로고
    • Total tract digestibility of nitrogen in pigs exposed to high environmental temperatures
    • Brestensky M., Heger J., Nitrayová S., Patrás P. Total tract digestibility of nitrogen in pigs exposed to high environmental temperatures. J. Anim. Sci. 2012, 90(Suppl. 4):101-103.
    • (2012) J. Anim. Sci. , vol.90 , Issue.SUPPL. 4 , pp. 101-103
    • Brestensky, M.1    Heger, J.2    Nitrayová, S.3    Patrás, P.4
  • 10
    • 0038721699 scopus 로고    scopus 로고
    • Cytokine-hormone interactions: tumor necrosis factor α impairs biologic activity and downstream activation signals of the insulin-like growth factor 1 receptor in myoblasts
    • Broussard S.R., McCusker R.H., Novakofski J.E., Strle K., Shen W.H., Johnson R.W., Freund G.G., Dantzer R., Kelley K.W. Cytokine-hormone interactions: tumor necrosis factor α impairs biologic activity and downstream activation signals of the insulin-like growth factor 1 receptor in myoblasts. Endocrinology 2003, 144:2988-2996.
    • (2003) Endocrinology , vol.144 , pp. 2988-2996
    • Broussard, S.R.1    McCusker, R.H.2    Novakofski, J.E.3    Strle, K.4    Shen, W.H.5    Johnson, R.W.6    Freund, G.G.7    Dantzer, R.8    Kelley, K.W.9
  • 11
    • 0029905070 scopus 로고    scopus 로고
    • Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival
    • Chandra R.K. Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:14304-14307.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 14304-14307
    • Chandra, R.K.1
  • 12
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow J.C., Young D.W., Golenbock D.T., Christ W.J., Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 1999, 274:10689-10692.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 14
    • 2342428466 scopus 로고    scopus 로고
    • Tumor necrosis factor α produces insulin resistance in skeletal muscle by activation of inhibitor κB kinase in a p38 MAPK-dependent manner
    • de Alvaro C., Teruel T., Hernandez R., Lorenzo M. Tumor necrosis factor α produces insulin resistance in skeletal muscle by activation of inhibitor κB kinase in a p38 MAPK-dependent manner. J. Biol. Chem. 2004, 279:17070-17078.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17070-17078
    • de Alvaro, C.1    Teruel, T.2    Hernandez, R.3    Lorenzo, M.4
  • 15
    • 0030185440 scopus 로고    scopus 로고
    • Influence of lipopolysaccharide-induced immune challenge and diet complexity on growth performance and acute-phase protein production in segregated early-weaned pigs
    • Dritz S.S., Owen K.Q., Goodband R.D., Nelssen J.L., Tokach M.D., Chengappa M.M., Blecha F. Influence of lipopolysaccharide-induced immune challenge and diet complexity on growth performance and acute-phase protein production in segregated early-weaned pigs. J. Anim. Sci. 1996, 74:1620-1628.
    • (1996) J. Anim. Sci. , vol.74 , pp. 1620-1628
    • Dritz, S.S.1    Owen, K.Q.2    Goodband, R.D.3    Nelssen, J.L.4    Tokach, M.D.5    Chengappa, M.M.6    Blecha, F.7
  • 17
    • 36749011345 scopus 로고    scopus 로고
    • N-3 PUFA attenuate lipopolysaccharide-induced down-regulation of Toll-like receptor 4 expression in porcine adipose tissue but does not alter the expression of other immune modulators
    • Gabler N.K., Spencer J.D., Webel D.M., Spurlock M.E. n-3 PUFA attenuate lipopolysaccharide-induced down-regulation of Toll-like receptor 4 expression in porcine adipose tissue but does not alter the expression of other immune modulators. J. Nutr. Biochem. 2008, 19:8-15.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 8-15
    • Gabler, N.K.1    Spencer, J.D.2    Webel, D.M.3    Spurlock, M.E.4
  • 18
    • 3442895916 scopus 로고    scopus 로고
    • Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
    • Gao Z., Zhang X., Zuberi A., Hwang D., Quon M.J., Lefevre M., Ye J. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol. Endocrinol. 2004, 18:2024-2034.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2024-2034
    • Gao, Z.1    Zhang, X.2    Zuberi, A.3    Hwang, D.4    Quon, M.J.5    Lefevre, M.6    Ye, J.7
  • 19
    • 0042591261 scopus 로고    scopus 로고
    • Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
    • Gao Z., Zuberi A., Quon M.J., Dong Z., Ye J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J. Biol. Chem. 2003, 278:24944-24950.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24944-24950
    • Gao, Z.1    Zuberi, A.2    Quon, M.J.3    Dong, Z.4    Ye, J.5
  • 22
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 23
    • 84863813734 scopus 로고    scopus 로고
    • Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs
    • Iyer M.N., Sarmah B.C., Tamuli M.K., Das A., Kalita D. Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs. Arch. Anim. Nutr. 2012, 66:271-282.
    • (2012) Arch. Anim. Nutr. , vol.66 , pp. 271-282
    • Iyer, M.N.1    Sarmah, B.C.2    Tamuli, M.K.3    Das, A.4    Kalita, D.5
  • 24
    • 0038143617 scopus 로고    scopus 로고
    • Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 poly-unsaturated fatty acids
    • Lee J.Y., Plakidas A., Lee W.H., Heikkinen A., Chanmugam P., Bray G., Hwang D.H. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 poly-unsaturated fatty acids. J. Lipid Res. 2003, 44:479-486.
    • (2003) J. Lipid Res. , vol.44 , pp. 479-486
    • Lee, J.Y.1    Plakidas, A.2    Lee, W.H.3    Heikkinen, A.4    Chanmugam, P.5    Bray, G.6    Hwang, D.H.7
  • 25
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee J.Y., Sohn K.H., Rhee S.H., Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 2001, 276:16683-16689.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 26
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated Toll-like receptor (Tlr)-4 induces synthesis of the closely related receptor Tlr-2 in adipocytes
    • Lin Y., Lee H., Berg A.H., Lisanti M.P., Shapiro L., Scherer P.E. The lipopolysaccharide-activated Toll-like receptor (Tlr)-4 induces synthesis of the closely related receptor Tlr-2 in adipocytes. J. Biol. Chem. 2000, 275:24255-24263.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24255-24263
    • Lin, Y.1    Lee, H.2    Berg, A.H.3    Lisanti, M.P.4    Shapiro, L.5    Scherer, P.E.6
  • 27
    • 0037101934 scopus 로고    scopus 로고
    • Metabolic effects of interleukin-6 in human splanchnic and adipose tissue
    • Lyngso D., Simonsen L., Bulow J. Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J. Physiol. 2002, 543:379-386.
    • (2002) J. Physiol. , vol.543 , pp. 379-386
    • Lyngso, D.1    Simonsen, L.2    Bulow, J.3
  • 28
    • 0035342124 scopus 로고    scopus 로고
    • Obesity and immune function relationships
    • Marti A., Marcos A., Martinez J.A. Obesity and immune function relationships. Obes. Rev. 2001, 2:131-140.
    • (2001) Obes. Rev. , vol.2 , pp. 131-140
    • Marti, A.1    Marcos, A.2    Martinez, J.A.3
  • 29
    • 79955880176 scopus 로고    scopus 로고
    • Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle
    • Masharani U.B., Maddux B.A., Li X., Sakkas G.K., Mulligan K., Schambelan M., Goldfine I.D., Youngren J.F. Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle. PLoS ONE 2011, 6:e19878.
    • (2011) PLoS ONE , vol.6
    • Masharani, U.B.1    Maddux, B.A.2    Li, X.3    Sakkas, G.K.4    Mulligan, K.5    Schambelan, M.6    Goldfine, I.D.7    Youngren, J.F.8
  • 31
    • 0029972520 scopus 로고    scopus 로고
    • Insulin increases lipogenic enzyme activity in human adipocytes in primary culture
    • Moustaid N., Jones B.H., Taylor J.W. Insulin increases lipogenic enzyme activity in human adipocytes in primary culture. J. Nutr. 1996, 126:865-870.
    • (1996) J. Nutr. , vol.126 , pp. 865-870
    • Moustaid, N.1    Jones, B.H.2    Taylor, J.W.3
  • 32
    • 33745198218 scopus 로고    scopus 로고
    • Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes
    • Musri M.M., Corominola H., Casamitjana R., Gomis R., Párrizas M. Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes. J. Biol. Chem. 2006, 281:17180-17188.
    • (2006) J. Biol. Chem. , vol.281 , pp. 17180-17188
    • Musri, M.M.1    Corominola, H.2    Casamitjana, R.3    Gomis, R.4    Párrizas, M.5
  • 33
    • 0036054083 scopus 로고    scopus 로고
    • The adaptive response of the immune system to the particular malnutrition of eating disorders
    • Nova E., Samartin S., Gomez S., Morande G., Marcos A. The adaptive response of the immune system to the particular malnutrition of eating disorders. Eur. J. Clin. Nutr. 2002, 56:S34-S37.
    • (2002) Eur. J. Clin. Nutr. , vol.56
    • Nova, E.1    Samartin, S.2    Gomez, S.3    Morande, G.4    Marcos, A.5
  • 34
    • 0025866975 scopus 로고
    • Regulation of acetyl-CoA carboxylase gene expression. Insulin induction of acetyl-CoA carboxylase and differentiation of 30A5 preadipocytes require prior cAMP action on the gene
    • Park K., Kim K.H. Regulation of acetyl-CoA carboxylase gene expression. Insulin induction of acetyl-CoA carboxylase and differentiation of 30A5 preadipocytes require prior cAMP action on the gene. J. Biol. Chem. 1991, 266:12249-12256.
    • (1991) J. Biol. Chem. , vol.266 , pp. 12249-12256
    • Park, K.1    Kim, K.H.2
  • 35
    • 33751228139 scopus 로고    scopus 로고
    • Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin A in mice
    • Pini M., Sennello J., Chan A., Fantuzzi L.G. Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin A in mice. Endocrinology 2006, 147:5019-5022.
    • (2006) Endocrinology , vol.147 , pp. 5019-5022
    • Pini, M.1    Sennello, J.2    Chan, A.3    Fantuzzi, L.G.4
  • 36
    • 33748998485 scopus 로고    scopus 로고
    • Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation
    • Pietsch J., Batra A., Stroh T., Fedke I., Glauben R., Okur B., Zeitz M., Siegmund B. Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation. Ann. N. Y. Acad. Sci. 2006, 1072:407-409.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1072 , pp. 407-409
    • Pietsch, J.1    Batra, A.2    Stroh, T.3    Fedke, I.4    Glauben, R.5    Okur, B.6    Zeitz, M.7    Siegmund, B.8
  • 38
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 1995, 270:26746-26749.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 39
    • 36749093765 scopus 로고    scopus 로고
    • In vivo methylation patterns of the leptin promoter in human and mouse
    • Stöger R. In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics 2006, 1:155-162.
    • (2006) Epigenetics , vol.1 , pp. 155-162
    • Stöger, R.1
  • 40
    • 37149040480 scopus 로고    scopus 로고
    • Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated
    • Suryawan A., Orellana R.A., Nguyen H.V., Jeyapalan A.S., Fleming J.R., Davis T.A. Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E1597-E1605.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Suryawan, A.1    Orellana, R.A.2    Nguyen, H.V.3    Jeyapalan, A.S.4    Fleming, J.R.5    Davis, T.A.6
  • 43
    • 17844391306 scopus 로고    scopus 로고
    • Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through Tlr4
    • Weatherill A.R., Lee J.Y., Zhao L., Lemay D.G., Youn H.S., Hwang D.H. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through Tlr4. J. Immunol. 2005, 174:5390-5397.
    • (2005) J. Immunol. , vol.174 , pp. 5390-5397
    • Weatherill, A.R.1    Lee, J.Y.2    Zhao, L.3    Lemay, D.G.4    Youn, H.S.5    Hwang, D.H.6
  • 44
    • 38949190229 scopus 로고    scopus 로고
    • Effect of sodium butyrate on growth performance and response to lipopolysaccharide in weanling pigs
    • Weber T.E., Kerr B.J. Effect of sodium butyrate on growth performance and response to lipopolysaccharide in weanling pigs. J. Anim. Sci. 2008, 86:442-450.
    • (2008) J. Anim. Sci. , vol.86 , pp. 442-450
    • Weber, T.E.1    Kerr, B.J.2
  • 47
    • 0031226385 scopus 로고    scopus 로고
    • Effect of level of chronic immune system activation on the growth and dietary lysine needs of pigs fed from 6 to 112kg
    • Williams N.H., Stahly T.S., Zimmerman D.R. Effect of level of chronic immune system activation on the growth and dietary lysine needs of pigs fed from 6 to 112kg. J. Anim. Sci. 1997, 75:2481-2496.
    • (1997) J. Anim. Sci. , vol.75 , pp. 2481-2496
    • Williams, N.H.1    Stahly, T.S.2    Zimmerman, D.R.3
  • 48
    • 0031230932 scopus 로고    scopus 로고
    • Effect of chronic immune system activation on body nitrogen retention, partial efficiency of lysine utilization, and lysine needs of pigs
    • Williams N.H., Stahly T.S., Zimmerman D.R. Effect of chronic immune system activation on body nitrogen retention, partial efficiency of lysine utilization, and lysine needs of pigs. J. Anim. Sci. 1997, 75:2472-2480.
    • (1997) J. Anim. Sci. , vol.75 , pp. 2472-2480
    • Williams, N.H.1    Stahly, T.S.2    Zimmerman, D.R.3
  • 49
    • 21044440466 scopus 로고    scopus 로고
    • Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism
    • Williamson D.L., Kimball S.R., Jefferson L.S. Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. Am. J. Physiol. Endocrinol. Metab. 2005, 289:E95-E104.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Williamson, D.L.1    Kimball, S.R.2    Jefferson, L.S.3
  • 50
    • 0036481709 scopus 로고    scopus 로고
    • Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
    • Yang W.S., Jeng C.Y., Wu T.J., Tanaka S., Funahashi T., Matsuzawa Y., Wang J.P., Chen C.L., Tai T.Y., Chuang L.M. Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 2002, 25:376-380.
    • (2002) Diabetes Care , vol.25 , pp. 376-380
    • Yang, W.S.1    Jeng, C.Y.2    Wu, T.J.3    Tanaka, S.4    Funahashi, T.5    Matsuzawa, Y.6    Wang, J.P.7    Chen, C.L.8    Tai, T.Y.9    Chuang, L.M.10


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