Effect of sodium butyrate on growth performance and response to lipopolysaccharide in weanling pigs

Journal of Animal Science

Volumn 86, Issue 2, 2008, Pages 442-450

  Weber, T E ^a   Kerr, B J ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Butyrate; Growth performance; Lipopolysaccharide; Weanling pig

Indexed keywords

ANIMALIA; ESCHERICHIA COLI; SUIDAE;

BUTYRIC ACID; CARBADOX; CYTOKINE; LIPOPOLYSACCHARIDE; TYLOSIN;

ANIMAL; ARTICLE; CALORIC INTAKE; DOSE RESPONSE; DRUG EFFECT; FEMALE; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; MALE; METABOLISM; NEWBORN; PHYSIOLOGY; RANDOMIZATION; SWINE; WEANING; WEIGHT GAIN;

ANIMALS; ANIMALS, NEWBORN; BUTYRIC ACID; CARBADOX; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY INTAKE; FEMALE; LIPOPOLYSACCHARIDES; MALE; RANDOM ALLOCATION; SWINE; TYLOSIN; WEANING; WEIGHT GAIN;

EID: 38949190229     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/jas.2007-0499     Document Type: Article

References (33)

1. Bach Knudsen, K. E., A. Serena, A. Kirstin, B. Kjaer, H. Jorgensen, and R. Engberg. 2005. Rye bread enhances the production and plasma concentration of butyrate but not the plasma concentrations of glucose and insulin in pigs. J. Nutr. 135:1696-1704.
2. Biagi, G., A. Piva, M. Moschini, E. Vezzali, and F. X. Roth. 2007. Performance, intestinal microflora, and wall morphology of weanling pigs fed sodium butyrate. J. Anim. Sci. 85:1184-1191.
3. Boukhliq, R., and G. B. Martin. 1997. Administration of fatty acids and gonadotrophin secretion in the mature ram. Anim. Reprod. Sci. 49:143-159.
4. Brix-Christensen, V., J. Gjedsted, S. K. Andersen, C. Vestergaard, J. Nielsen, T. Rix, R. Nyboe, N. T. Anderson, A. Larsson, O. Schmitz, and E. Tønnesen. 2005. Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: The contribution of essential organs. Acta Anaesthesiol. Scand. 49:991-998.
5. Bugaut, M. 1987. Occurrence, absorption, and metabolism of short chain fatty acids in the digestive tract of mammals. Comp. Bio-chem. Physiol. 86:439-472.
6. Claus, R., D. Gunthner, and H. Letzgub. 2006. Effects of feeding fat-coated butyrate on mucosal morphology and function in the small intestine of the pig. J. Anim. Physiol. Anim. Nutr. (Berl.) 91:312-318.
7. Frost, R. A., G. J. Nystrom, and C. H. Lang. 2002. Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle. Am. J. Physiol. 283:R698-R709.
8. Fukae, J., Y. Amasaki, T. Bohgaki, S. Yasuda, S. Jodo, T. Atsumi, and T. Koike. 2005. Butyrate suppresses tumor necrosis factor α production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element. Arthritis Rheum. 52:2697-2707.
9. Haddad, F., F. Zaldivar, D. M. Cooper, and G. R. Adams. 2005. IL-6-induced skeletal muscle atrophy. J. Appl. Physiol. 98:911-917.
10. Hathaway, M. R., W. R. Dayton, M. E. White, T. L. Henderson, and T. B. Henningson. 1996. Serum insulin-like growth factor I (IGF-I) concentrations are increased in pigs fed antimicrobials. J. Anim. Sci. 74:1541-1547.
11. Hathaway, M. R., W. R. Dayton, M. E. White, T. L. Henderson, D. A. Young, and T. N. Doan. 1999. Effect of feed intake on antimicrobially induced increases in porcine serum insulin-like growth factor I. J. Anim. Sci. 77:3208-3214.
12. Iezzi, S., G. Cossu, C. Nervi, V. Sartorelli, and P. L. Puri. 2002. Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. Proc. Natl. Acad. Sci. USA 99:7757-7762.
13. Janssen, S. P., G. Gayan-Ramirez, A. Van den Bergh, P. Herijgers, K. Maes, E. Verbeken, and M. Decramer. 2005. Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats. J. Anim. Sci. 111:996-1005.
14. Kerr, B. J., M. T. Kidd, J. A. Cuaron, K. L. Bryant, T. M. Parr, C. V. Maxwell, and J. M. Campbell. 2004. Isoleucine requirements and ratios in starting (7 to 11 kg) pigs. J. Anim. Sci. 82:2333-2342.
15. Kotunia, A., J. Wolinski, D. Laubitz, M. Jurkowska, V. Rome, P. Guilloteau, and R. Zabielski. 2004. Effect of sodium butyrate on the small intestine development in neonatal piglets fed by artificial sow. J. Physiol. Pharmacol. 55:59-68.
16. Lang, C. H., C. Silvis, N. Deshpande, G. Nystrom, and R. A. Frost. 2003. Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1 β, -6, and high-mobility group protein-1 in skeletal muscle. Shock 19:538-546.
17. Leeson, S., H. Namkung, M. Antongiovanni, and E. H. Lee. 2005. Effect of butyric acid on the performance and carcass yield of broiler chickens. Poult. Sci. 84:1418-1422.
18. Leoni, F., G. Fossati, E. C. Lewis, J. K. Lee, G. Porro, P. Pagani, D. Modena, M. L. Moras, P. Pozzi, L. L. Reznikov, B. Siegmund, G. Fantuzzi, C. A. Dinarello, and P. Mascagni. 2005. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol. Med. 11:1-15.
19. Li, C. J., and T. H. Elsasser. 2005. Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: Involvement of caspase and proteosome pathways. J. Anim. Sci. 83:89-97.
20. Lieskovska, J., D. Guo, and E. Derman. 2003. Growth impairment in IL-6-overexpressing transgenic mice is associated with induction of SOCS3 mRNA. Growth Horm. IGF Res. 13:26-35.
21. Manzanilla, E. G., M. Nofrarias, M. Anguita, M. Castillo, J. F. Perez, S. M. Matin-Orue, C. Kamel, and J. Gasa. 2006. Effects of butyrate, avilamycin, and a plant extract combination on the intestinal equilibrium of early-weaned pigs. J. Anim. Sci. 84:2743-2751.
22. Milo, L. A., K. A. Reardon, and K. A. Tappenden. 2002. Effects of short-chain fatty acid-supplemented total parenteral nutrition on intestinal pro-inflammatory cytokine abundance. Dig. Dis. Sci. 47:2049-2055.
23. Niewold, T. A. 2007. The nonantibiotic, anti-inflammatory effect of antimicrobial growth promoters, the real mode of action? A hypothesis. Poult. Sci. 86:605-609.
24. NRC. 1998. Nutrient Requirements of Swine. 10th ed. Natl. Acad. Press, Washington, DC.
25. Rodriguez-Cabezas, M. E., J. Galvez, D. Camuesco, M. D. Lorente, A. Concha, O. Martinez-Augustin, L. Redondo, and A. Zarzuelo. 2003. Intestinal anti-inflammatory activity of dietary fiber (Plantago ovata seeds) in HLA-B27 transgenic rats. Clin. Nutr. 22:463-471.
26. Schroeder, F. A., C. L. Lin, W. E. Crusio, and S. Akbarian. 2007. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol. Psychiatry 62:55-64.
27. Spurlock, M. E., M. A. Ranalletta, S. G. Cornelius, G. R. Frank, G. M. Willis, S. Ji, A. L. Grant, and C. A. Bidwell. 1998. Leptin expression in porcine adipose tissue is not increased by endotoxin but is reduced by growth hormone. J. Interferon Cytokine Res. 18:1051-1058.
28. Touchette, K. J., J. A. Carroll, G. L. Allee, R. L. Matteri, C. J. Dyer, L. A. Beausang, and M. E. Zannelli. 2002. Effect of spray-dried plasma and lipopolysaccharide exposure on weaned pigs: I. Effects on the immune axis of weaned pigs. J. Anim. Sci. 80:494-501.
29. Walsh, M. C., D. M. Sholly, R. B. Hinson, S. A. Trapp, A. L. Sutton, J. S. Radcliffe, J. W. Smith II, and B. T. Richert. 2007. Effects of Acid LAC and Kem-Gest acid blends on growth performance and microbial shedding in weanling pigs. J. Anim. Sci. 85:459-467.
30. Weber, T. E., and M. E. Spurlock. 2004. Leptin alters antibody isotype in the pig in vivo, but does not regulate cytokine expression or stimulate STAT3 signaling in peripheral blood monocytes in vitro. J. Anim. Sci. 82:1630-1640.
31. Williams, N. H., T. S. Stahly, and D. R. Zimmerman. 1997. Effect of chronic immune system activation on the rate, efficiency, and composition of growth and lysine needs of pigs fed from 6 to 27 kg. J. Anim. Sci. 75:2463-2471.
32. Wright, K. J., R. Balaji, C. M. Hill, S. S. Dritz, E. L. Knoppel, and J. E. Minton. 2000. Integrated adrenal, somatotropic, and immune responses of growing pigs to treatment with lipopolysaccharide. J. Anim. Sci. 78:1892-1899.
33. Zhang, L. T., Y. M. Yao, J. Q. Lu, X. J. Van, Y. Yu, and Z. Y. Sheng. 2007. Sodium butyrate prevents lethality of severe sepsis in rats. Shock 27:672-677.