Improved in vitro efficacy of gold nanoconstructs by increased loading of G-quadruplex aptamer

Nano Letters

Volumn 14, Issue 5, 2014, Pages 2843-2848

  Dam, Duncan Hieu M ^a   Lee, Raymond C ^a   Odom, Teri W ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Northwestern University   (United States)

Author keywords

aptamers; Gold nanostars; nanoconstructs; nucleolin; oligonucleotide loading; polyvalency

Indexed keywords

CELL DEATH; GOLD; OLIGONUCLEOTIDES;

APTAMERS; GOLD NANOSTARS; NANOCONSTRUCTS; NUCLEOLIN; POLYVALENCY;

LOADING;

APTAMER; GOLD; GUANINE QUADRUPLEX; NANOMATERIAL; NUCLEOLIN; OLIGONUCLEOTIDE; PHOSPHOPROTEIN; RNA BINDING PROTEIN; SINGLE STRANDED DNA;

APOPTOSIS; CELL LINE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HUMAN; TUMOR CELL LINE;

APOPTOSIS; APTAMERS, NUCLEOTIDE; CELL LINE; CELL LINE, TUMOR; DNA, SINGLE-STRANDED; DRUG DELIVERY SYSTEMS; G-QUADRUPLEXES; GOLD; HUMANS; NANOSTRUCTURES; OLIGONUCLEOTIDES; PHOSPHOPROTEINS; RNA-BINDING PROTEINS;

EID: 84900513441     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/nl500844m     Document Type: Article

References (30)

1. Giljohann, D. A.; Seferos, D. S.; Daniel, W. L.; Massich, M. D.; Patel, P. C.; Mirkin, C. A. Gold nanoparticles for biology and medicine Angew. Chem., Int. Ed. 2010, 49, 3280-94
2. Liao, H. W.; Nehl, C. L.; Hafner, J. H. Biomedical applications of plasmon resonant metal nanoparticles Nanomedicine-U.K. 2006, 1, 201-208
3. Hu, M.; Chen, J. Y.; Li, Z. Y.; Au, L.; Hartland, G. V.; Li, X. D.; Marquez, M.; Xia, Y. N. Gold nanostructures: engineering their plasmonic properties for biomedical applications Chem. Soc. Rev. 2006, 35, 1084-1094
4. Dykman, L.; Khlebtsov, N. Gold nanoparticles in biomedical applications: recent advances and perspectives Chem. Soc. Rev. 2012, 41, 2256-2282
5. Albanese, A.; Tang, P. S.; Chan, W. C. W. The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems Annu. Rev. Biomed Eng. 2012, 14, 1-16
6. Herne, T. M.; Tarlov, M. J. Characterization of DNA probes immobilized on gold surfaces J. Am. Chem. Soc. 1997, 119, 8916-8920
7. Chou, L. Y.; Zagorovsky, K.; Chan, W. C. DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination Nat. Nanotechnol. 2014, 9, 148-55
8. Agasti, S. S.; Chompoosor, A.; You, C. C.; Ghosh, P.; Kim, C. K.; Rotello, V. M. Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles J. Am. Chem. Soc. 2009, 131, 5728-5730
9. Giljohann, D. A.; Seferos, D. S.; Patel, P. C.; Millstone, J. E.; Rosi, N. L.; Mirkin, C. A. Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles Nano Lett. 2007, 7, 3818-21
10. Huang, C. C.; Huang, Y. F.; Cao, Z. H.; Tan, W. H.; Chang, H. T. Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors Anal. Chem. 2005, 77, 5735-5741
11. Huang, Y. F.; Sefah, K.; Bamrungsap, S.; Chang, H. T.; Tan, W. Selective Photothermal Therapy for Mixed Cancer Cells Using Aptamer-Conjugated Nanorods Langmuir 2008, 24, 11860-11865
12. Rosi, N. L.; Mirkin, C. A. Nanostructures in biodiagnostics Chem. Rev. 2005, 105, 1547-62
13. Zhang, X.; Servos, M. R.; Liu, J. Instantaneous and quantitative functionalization of gold nanoparticles with thiolated DNA using a pH-assisted and surfactant-free route J. Am. Chem. Soc. 2012, 134, 7266-9
14. Dam, D. H.; Lee, J. H.; Sisco, P. N.; Co, D. T.; Zhang, M.; Wasielewski, M. R.; Odom, T. W. Direct observation of nanoparticle-cancer cell nucleus interactions ACS Nano 2012, 6, 3318-26
15. Dam, D. H.; Culver, K. S.; Odom, T. W. Grafting Aptamers onto Gold Nanostars Increases in Vitro Efficacy in a Wide Range of Cancer Cell Types Mol. Pharmaceutics 2014, 11, 580-587
16. Mammen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors Angew. Chem., Int. Ed. 1998, 37, 2755-2794
17. Cutler, J. I.; Zhang, K.; Zheng, D.; Auyeung, E.; Prigodich, A. E.; Mirkin, C. A. Polyvalent nucleic acid nanostructures J. Am. Chem. Soc. 2011, 133, 9254-7
18. Liu, J.; Lu, Y. A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles J. Am. Chem. Soc. 2003, 125, 6642-3
19. Jana, N. R.; Gearheart, L.; Murphy, C. J. Seeding growth for size control of 5-40 nm diameter gold nanoparticles Langmuir 2001, 17, 6782-6786
20. Elghanian, R.; Storhoff, J. J.; Mucic, R. C.; Letsinger, R. L.; Mirkin, C. A. Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles Science 1997, 277, 1078-1081
21. Mucic, R. C.; Storhoff, J. J.; Mirkin, C. A.; Letsinger, R. L. DNA-directed synthesis of binary nanoparticle network materials J. Am. Chem. Soc. 1998, 120, 12674-12675
22. Cutler, J. I.; Auyeung, E.; Mirkin, C. A. Spherical Nucleic Acids J. Am. Chem. Soc. 2012, 134, 1376-1391
23. Zhang, X.; Liu, B.; Dave, N.; Servos, M. R.; Liu, J. Instantaneous attachment of an ultrahigh density of nonthiolated DNA to gold nanoparticles and its applications Langmuir 2012, 28, 17053-60
24. Bates, P. J.; Laber, D. A.; Miller, D. M.; Thomas, S. D.; Trent, J. O. Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer Exp Mol. Pathol 2009, 86, 151-164
25. Christian, S.; Pilch, J.; Akerman, M. E.; Porkka, K.; Laakkonen, P.; Ruoslahti, E. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels J. Cell Biol. 2003, 163, 871-878
26. Hovanessian, A. G.; Soundaramourty, C.; El Khoury, D.; Nondier, I.; Svab, J.; Krust, B., Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization. PLoS One 2010, 5.
27. Reyes-Reyes, E. M.; Teng, Y.; Bates, P. J. A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism Cancer Res. 2010, 70, 8617-8629
28. Xie, J. P.; Lee, J. Y.; Wang, D. I. C. Seedless, surfactantless, high-yield synthesis of branched gold nanocrystals in HEPES buffer solution Chem. Mater. 2007, 19, 2823-2830
29. Girvan, A. C.; Teng, Y.; Casson, L. K.; Thomas, S. D.; Juliger, S.; Ball, M. W.; Klein, J. B.; Pierce, W. M., Jr.; Barve, S. S.; Bates, P. J. AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin Mol. Cancer Ther. 2006, 5, 1790-9
30. Li, J.; Wientjes, M. G.; Au, J. L. Pancreatic cancer: pathobiology, treatment options, and drug delivery AAPS J. 2010, 12, 223-32