Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma

Cancer Letters

Volumn 348, Issue 1-2, 2014, Pages 146-155

  Li, Xia ^a   Zeng, Xueli ^a   Sun, Jianguo ^a,b   Li, Hua ^a   Wu, Ping ^a,b,c   Fung, Kwok Pui ^b   Liu, Feiyan ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c Zhejiang University   (China)

Author keywords

Apoptosis; Drug resistant HepG2 cells; Imperatorin; Mcl 1

Indexed keywords

ANTINEOPLASTIC AGENT; FUROCOUMARIN; PENTOSALEN; PROTEIN BAK; PROTEIN BAX; PROTEIN MCL 1;

ANGELICA DAHURICA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CHINESE MEDICINE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER; LIVER CELL CARCINOMA; MOLECULAR MECHANICS; PLANT ROOT; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR GROWTH; XENOGRAFT;

APOPTOSIS; DRUG-RESISTANT HEPG2 CELLS; IMPERATORIN; MCL-1;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; HEP G2 CELLS; HUMANS; K562 CELLS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; PROTEOLYSIS; PSORALENS; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR BURDEN; U937 CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84900506925     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.03.017     Document Type: Article

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