Modulation of gamma globin genes expression by histone deacetylase inhibitors: An in vitro study

British Journal of Haematology

Volumn 165, Issue 5, 2014, Pages 714-721

  Ronzoni, Luisa ^a,b   Sonzogni, Laura ^a   Fossati, Gianluca ^c   Modena, Daniela ^c   Trombetta, Elena ^b   Porretti, Laura ^b   Cappellini, Maria Domenica ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c Italfarmaco SpA   (Italy)

Author keywords

Fetal haemoglobin induction; Globin gene transcription; Histone deacetylase inhibitor; Sickle cell disease; thalassaemia

Indexed keywords

BUTYRIC ACID; GIVINOSTAT; HEMOGLOBIN; HEMOGLOBIN GAMMA CHAIN; HYDROXYUREA; CARBAMIC ACID DERIVATIVE; CD34 ANTIGEN; HISTONE DEACETYLASE INHIBITOR;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HBG1 GENE; HBG2 GENE; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; SICKLE CELL ANEMIA; BIOSYNTHESIS; BLOOD; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; ERYTHROID PRECURSOR CELL; GENETICS; METABOLISM; PROCEDURES;

ADULT; ANEMIA, SICKLE CELL; ANTIGENS, CD34; BUTYRIC ACID; CARBAMATES; CELL DIFFERENTIATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; GAMMA-GLOBINS; GENE EXPRESSION REGULATION; HEMOGLOBINS; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXYUREA;

EID: 84900498831     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12814     Document Type: Article

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