Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4- triazol-3-yl)pyridines as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 47-58

  Qin, Mingze ^a   Zhai, Xin ^a   Xie, Hongbo ^b   Ma, Junjie ^a   Lu, Kuan ^a   Wang, Yu ^a   Wang, Lihui ^a   Gu, Yucheng ^c   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

4 (2 (Dimethylamino)ethyl) 4H 1,2,4 triazole; Antitumor activity; Synthesis

Indexed keywords

2 (2 CHLORO 4 FLUOROBENZYLIDENE) N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXYL] 3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; 2 (2,3 DICHLOROBENZYLIDENE) N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXYL] 3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; 2 (2,4 DIFLUOROBENZYLIDENE) N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXYL] 3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; 2 (3 BROMOBENZYLIDENE) N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXYL] 3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; 2 (4 CHLOROBENZYLIDENE) N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXYL] 3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; 2 BENZYLIDENE N [3 FLUORO 4 [2 (1 METHYL 1H 1,2,4 TRIAZOL 5 YL)PYRIDIN 4 YLOXY]PHENYL]HYDRAZINECARBOXAMIDE; 2 BENZYLIDENE N [3 FLUORO 4 [2 (4 METHYL 4H 1,2,4 TRIAZOL 3 YL)PYRIDIN 4 YLOXY]PHENYL]HYDRAZINECARBOXAMIDE; 2 BENZYLIDENE N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXY]3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; 2 [ 4 [ 2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDINE DERIVATIVE; 2 [3 [4 (2 FLUORO 4 NITROPHENOXY)PYRIDIN 2 YL] 4H 1,2,4 TRIAZOL 4 YL] N,N DIMETHYLETHANAMINE; 3 FLUORO 4 [2 (1 METHYL 1H 1,2,4 TRIAZOL 5 YL)PYRIDIN 4 YLOXY]ANILINE; 3 FLUORO 4 [2 (4 METHYL 4H 1,2,4 TRIAZOL 3 YL)PYRIDIN 4YLOXY]ANILINE; 4 (2 FLUORO 4 NITROPHENOXY) 2 (1 METHYL 1H 1,2,4 TRIAZOL 5 YL)PYRIDINE; 4 (2 FLUORO 4 NITROPHENOXY)PICOLINAMIDE; 4 (2 FLUORO 4 NITROPHENOXY)PICOLINOHYDRAZIDE; 4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXY] 3 FLUOROANILINE; ANTINEOPLASTIC AGENT; METHYL 4 (2 FUORO 4 NITROPHENOXY)PICOLINATE; METHYL 4 CHLOROPICOLINATE; N [(DIMETHYLAMINO)METHYLENE] 4 (2 FLUORO 4 NITROPHENOXY) PICOLINAMIDE; N [3 FLUORO 4 [2 (1 METHYL 1H 1,2,4 TRIAZOL 5 YL)PYRIDIN 4YLOXY]PHENYL]HYDRAZINECARBOXAMIDE; N [3 FLUORO 4 [2 (4 METHYL 4H 1,2,4 TRIAZOL 3 YL)PYRIDIN 4 YLOXY]PHENYL]HYDRAZINECARBOXAMIDE; N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL] PYRIDIN 4 YLOXY] 3 FLUOROPHENYL]HYDRAZINECARBOXAMIDE; N [4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXYL] 3FLUOROPHENYL] 2 ( 4 FLUOROBENZYLIDENE)HYDRAZINECARBOXAMIDE; N' [4 (2 FLUORO 4 NITROPHENOXY)PICOLINOYL] N,N DIMETHYLFORMOHYDRAZONAMIDE; PHENYL 3 FLUORO 4 [2 (1 METHYL 1H 1,2,4 TRIAZOL 5 YL)PYRIDIN 4 YLOXY]PHENYLCARBAMATE; PHENYL 3 FLUORO 4 [2 (4 METHYL 4H 1,2,4 TRIAZOL 3 YL)PYRIDIN 4 YLOXY]PHENYLCARBAMATE; PHENYL 4 [2 [4 [2 (DIMETHYLAMINO)ETHYL] 4H 1,2,4 TRIAZOL 3 YL]PYRIDIN 4 YLOXY] 3 FLUOROPHENYLCARBAMATE; SORAFENIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; B RAF KINASE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HT 29 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84900482017     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.059     Document Type: Article

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