SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 17, 2013, Pages 5246-5260

Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors

(7) Qi, Baohui a Mi, Bin a Zhai, Xin a Xu, Ziyi a Zhang, Xiaolong a Tian, Zeru a Gong, Ping a

a SHENYANG PHARMACEUTICAL UNIVERSITY (China)

Author keywords

Anti tumor; c Met; Kinase inhibitor; Quinoline; Semicarbazone

Indexed keywords

FORETINIB; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (4 METHYLPIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2 FLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (4 METHYLPIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2,4 DIFLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (4 METHYLPIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 CHLOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (4 METHYLPIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 FLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (4 METHYLPIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (BENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2 CYANOBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2 FLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2 NITROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2 TRIFLUOROMETHYLBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2,4 DIFLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (2,5 DIMETHOXYBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (3 METHOXYBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (3 NITROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (3,4 DIFLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 CHLOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 FLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 NITROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PIPERIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (BENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PYRROLIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 CHLOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PYRROLIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 FLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 (PYRROLIDIN 1 YL)PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (BENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 MORPHOLINO PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 CHLOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 MORPHOLINO PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 FLUOROBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 MORPHOLINO PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 TRIFLUOROMETHOXYBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 MORPHOLINO PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (4 TRIFLUOROMETHYLBENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6 METHOXY 7 (3 MORPHOLINO PROPOXY)QUINOLIN 4 YLOXY)PHENYL] N4 (BENZYLIDENE)SEMICARBAZIDE; N1 [3 FLUORO 4 (6,7 DISUBSTITUTED QUINOLIN 4 YLOXY)PHENYL] N4 ARYLIDENESEMICARBAZIDE DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; NUCLEAR OVERHAUSER EFFECT; PROTEIN PHOSPHORYLATION; STOMACH CANCER; STRUCTURE ACTIVITY RELATION;

ANTI-TUMOR; C-MET; KINASE INHIBITOR; QUINOLINE; SEMICARBAZONE;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MET; QUINOLINES; SEMICARBAZIDES; SEMICARBAZONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881372377 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.06.026 Document Type: Article

Times cited : (48)

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