Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl- 4-aminoquinazoline derivatives as potent antitumor agents

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 534-541

  Jiang, Nan ^a   Zhai, Xin ^a   Zhao, Yanfang ^a   Liu, Yajing ^a   Qi, Baohui ^a   Tao, Haiyan ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

2 (2 arylmethylene)hydrazinyl 4 aminoquinazoline; Cytotoxicity; Synthesis

Indexed keywords

2 [2 (2 CHLORO 4 FLUOROBENZYLIDENE)HYDRAZINYL] N (1 METHYLPIPERIDIN 4 YL)QUINAZOLIN 4 AMINE; 2 [2 (2 HYDROXYBENZYLIDENE)HYDRAZINYL] N (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; 2 [2 (2,5 DIMETHOXYBENZYLIDENE)HYDRAZINYL] N (1 METHYLPIPERIDIN 4 YL)QUINAZOLIN 4 AMINE; 2 [2 (3 HYDROXYBENZYLIDENE)HYDRAZINYL] (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; 2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL] N (1 METHYLPIPERIDIN 4 YL)QUINAZOLIN 4 AMINE; 2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL] N (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; 2 [2 (4 FLUORBENZYLIDENE)HYDRAZINYL] N (1 METHYLPIPERIDIN 4 YL)QUINAZOLIN 4 AMINE; 2 [2 (4 FLUOROBENZYLIDENE)HYDRAZINYL] N (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; 2 [2 [(1 BENZYL 1H IMIDAZOL 2 YL)METHYLENE]HYDRAZINYL] N (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; 2 [2 [[1 (2,3 DICHLOROBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL] N (1 METHYLPIPERIDIN 4 YL)QUINAZOLIN 4 AMINE; 2 [2 [[1 (4 FLUOROBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL] N (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; 2 [2 [[1 (4 METHYLBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL] N (3 MORPHOLINOPROPYL)QUINAZOLIN 4 AMINE; ANTINEOPLASTIC AGENT; GEFITINIB; HYDRAZINYL 4 AMINOQUINAZOLINE DERIVATIVE; N 1 [2 [2 (2 CHLORO 4 FLUOROBENZYLIDENE)HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 (2 CHLORO 4 FLUOROBENZYLIDENE)HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; N 1 [2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 (4 CHLOROBENZYLIDENE)HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; N 1 [2 [2 (4 FLUOROBENZYLIDENE)HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 (4 FLUOROBENZYLIDENE)HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; N 1 [2 [2 [(1 BENZYL 1H IMIDAZOL 2 YL)METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 [(1 BENZYL 1H IMIDAZOL 2 YL)METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; N 1 [2 [2 [[1 (2,3 DICHLOROBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 [[1 (2,3 DICHLOROBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; N 1 [2 [2 [[1 (4 FLUOROBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 [[1 (4 FLUOROBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; N 1 [2 [2 [[1 (4 METHYLBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 2,N 2 DIMETHYLETHANE 1,2 DIAMINE; N 1 [2 [2 [[1 (4 METHYLBENZYL) 1H IMIDAZOL 2 YL]METHYLENE]HYDRAZINYL]QUINAZOLIN 4 YL] N 3,N 3 DIMETHYLPROPANE 1,3 DIAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; INHIBITORY CONCENTRATION 50; QUINAZOLINES;

EID: 84864405416     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.039     Document Type: Article

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