Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4323-4329

  Zhan, Wenhu ^a,b   Li, Yanyang ^a   Huang, Weiping ^a,b   Zhao, Yanjin ^a   Yao, Zhenglin ^a,b   Yu, Shanyou ^a,b   Yuan, Shoujun ^a   Jiang, Falong ^a,b   Yao, Shan ^a,b   Li, Shuxin ^a,b  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Antitumor activity; Bis aryl ureas; Raf kinase; Synthesis

Indexed keywords

1 (2 CHLORO 6 METHYLPHENYL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (3 CHLORO 4 FLUOROPHENYL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (3,4 DICHLOROPHENYL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (4 BROMO 2 FLUOROPHENYL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (4 FLUOROPHENYL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (4 METHOXYPHENYL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (5 METHYLISOXAZOL 3 YL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 (BENZO[D][1,3]DIOXOL 5 YL) 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 (3,4 DICHLOROPHENYL)UREA; 1 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 (3,4,5 TRIMETHOXYPHENYL)UREA; 1 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 [2 CHLORO 5 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 [3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 [4 METHYL 3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [2 CHLORO 5 (TRIFLUOROMETHYL)PHENYL] 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL] 3 [3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [2 CHLORO 4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [4 [2 [5 (TRIFLUOROMETHYL) 1H IMIDAZOL 2 YL]PYRIDIN 4 YLOXY]PHENYL]UREA; ABELSON KINASE; BIS ARYL UREA DERIVATIVE; CD135 ANTIGEN; CYCLIN DEPENDENT KINASE 2; ENZYME INHIBITOR; PROTEIN KINASE B; RAF PROTEIN; SCATTER FACTOR RECEPTOR; SORAFENIB; STEM CELL FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CANCER; SINGLE DRUG DOSE; STOMACH CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZENESULFONATES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PROTEIN KINASE INHIBITORS; PYRIDINES; RAF KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84863190089     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.051     Document Type: Article

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