Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock

Biochemical Journal

Volumn 460, Issue 2, 2014, Pages 309-316

  Wang, Zhen ^a,b   Lambden, Simon ^a   Taylor, Valerie ^b   Sujkovic, Elizabeth ^a   Nandi, Manasi ^c   Tomlinson, James ^a   Dyson, Alex ^b   McDonald, Neil ^d   Caddick, Stephen ^b   Singer, Mervyn ^b   Leiper, James ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Drug research; Infection; Nitric oxide; Nitric oxide synthase; Shock

Indexed keywords

CATECHOLAMINE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; HYDROLASE INHIBITOR; L 257; LIPOPOLYSACCHARIDE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NORADRENALIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTOXEMIA; ENZYME INHIBITION; HEMODYNAMICS; KIDNEY DYSFUNCTION; MALE; MORTALITY; NONHUMAN; PERITONEUM MACROPHAGE; PERITONITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; SURVIVAL; TACHYCARDIA; TISSUE PERFUSION;

AMIDOHYDROLASES; ANIMALS; ARGININE; ENDOTOXEMIA; ENZYME INHIBITORS; FLUID THERAPY; HEMODYNAMICS; MACROPHAGES, PERITONEAL; MALE; NOREPINEPHRINE; PERITONITIS; RATS; RATS, WISTAR; SHOCK, SEPTIC;

EID: 84900472299     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131666     Document Type: Article

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