Effect of chronic elevated asymmetric dimethylarginine (ADMA) levels on granulopoiesis

Annals of Hematology

Volumn 92, Issue 4, 2013, Pages 505-508

  Beutel, Gernot ^a   Perthel, Ronny ^b   Suntharalingam, Mayuren ^a   Bode Böger, Stefanie M ^c   Martens Lobenhoffer, Jens ^c   Kielstein, Jan T ^a   Kielstein, Heike ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

ADMA; Asymmetric dimethylarginine; Granulopoiesis; Lymphocytes subsets; Peripheral blood count

Indexed keywords

N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE; ARGININE; DRUG DERIVATIVE; ENZYME INHIBITOR; N,N DIMETHYLARGININE; N,N-DIMETHYLARGININE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CELL SUBPOPULATION; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; GRANULOPOIESIS; HISTOLOGY; LEUKOCYTE COUNT; MALE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD CELL COUNT; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GRANULOCYTE; HEMATOPOIESIS; LEUKOCYTE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ARGININE; BLOOD CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GRANULOCYTES; HEMATOPOIESIS; KILLER CELLS, NATURAL; LEUKOCYTES; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

MLCS; MLOWN;

EID: 84877031802     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-012-1636-6     Document Type: Article

References (12)

1. Zoccali C, Benedetto FA, Maas R, Mallamaci F, Tripepi G, Malatino LS, Boger R (2002) Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J Am Soc Nephrol 13:490-496
2. Miyazaki H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S, Imaizumi T (1999) Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 99:1141-1146
3. Schroecksnadel K, Weiss G, Stanger O, Teerlink T, Fuchs D (2007) Increased asymmetric dimethylarginine concentrations in stimulated peripheral blood mononuclear cells. Scand J Immunol 65:525-529
4. Chen M, Li Y, Yang T, Wang Y, Bai Y, Xie X (2008) ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells. Cytokine 43:149-159
5. Greenberg SS, Ouyang J, Zhao X, Giles TD (1998) Human and rat neutrophils constitutively express neural nitric oxide synthase mRNA. Nitric Oxide 2:203-212
6. Roman A, Legallo R, McGahren ED (2004) Blocking of endogenous nitric oxide increases white blood cell accumulation in rat lung. J Pediatr Surg 39:48-52
7. Michurina T, Krasnov P, Balazs A, Nakaya N, Vasilieva T, Kuzin B, Khrushchov N, Mulligan RC, Enikolopov G (2004) Nitric oxide is a regulator of hematopoietic stem cell activity. Mol Ther 10:241-248
8. Kurz K, Teerlink T, Sarcletti M, Weiss G, Zangerle R, Fuchs D (2009) Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers. Pharmacol Res 60:508-514
9. Molnar M, Suto T, Toth T, Hertelendy F (1994) Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am J Obstet Gynecol 170:1458-1466
10. Kielstein JT, Boger RH, Bode-Boger SM, Schaffer J, Barbey M, Koch KM, Frolich JC (1999) Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease. J Am Soc Nephrol 10:594-600
11. Chen LY, Mehta JL (1996) Variable effects of l-arginine analogs on l-arginine-nitric oxide pathway in human neutrophils and platelets may relate to different nitric oxide synthase isoforms. J Pharmacol Exp Ther 276:253-257
12. Bedoui S, Kuhlmann S, Nave H, Drube J, Pabst R, von Horsten S (2001) Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: mobilization of B-1-like B-lymphocytes and activated monocytes. J Neuroimmunol 117:125-132