Maritime halophyte species from southern Portugal as sources of bioactive molecules

Marine Drugs

Volumn 12, Issue 4, 2014, Pages 2228-2244

  Rodrigues, Maria João ^a   Gangadhar, Katkam N ^a,b   Vizetto Duarte, Catarina ^a   Wubshet, Sileshi G ^c   Nyberg, Nils T ^c   Barreira, Luísa ^a   Varela, João ^a   Custódio, Luísa ^a  

^a UNIVERSITY OF ALGARVE   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Anti inflammatory; Antioxidant; Cytotoxicity; Halophytes; Juncunol; Juncus acutus

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ARTHROCNEMUM MACROSTACHYUM EXTRACT; BIOLOGICAL PRODUCT; CHLOROFORM; CYTOTOXIC AGENT; ETOPOSIDE; GALLIC ACID; HALIMIONE PORTULACOIDES EXTRACT; HEXANE; JUNCUNOL; JUNCUS ACUTUS EXTRACT; LIPOPOLYSACCHARIDE; MESEMBRYANTHEMUM EDULE EXTRACT; METHANOL; NATURAL PRODUCT; NITRIC OXIDE; PHENOL DERIVATIVE; PLANTAGO CORONOPUS EXTRACT; UNCLASSIFIED DRUG; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; BIPHENYL DERIVATIVE; PICRIC ACID; PLANT EXTRACT; SCAVENGER;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHROCNEMUM MACROSTACHYUM; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; HALIMIONE PORTULACOIDES; HALOPHYTE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; JUNCUS ACUTUS; MACROPHAGE; MARINE SPECIES; MESEMBRYANTHEMUM EDULE; MOUSE; NONHUMAN; PLANTAGO CORONOPUS; PORTUGAL; RAT; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; IC50; ISOLATION AND PURIFICATION; METABOLISM; TUMOR CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CELL LINE; CELL LINE, TUMOR; FREE RADICAL SCAVENGERS; HUMANS; INHIBITORY CONCENTRATION 50; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; PHENOLS; PICRATES; PLANT EXTRACTS; PORTUGAL; SALT-TOLERANT PLANTS;

EID: 84900450279     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12042228     Document Type: Article

References (48)

1. Redondo-Gómez, S.; Mateos-Naranjo, E.; Figueroa, M.E.; Davy, A.J. Salt stimulation of growth and photosynthesis in an extreme halophyte Arthrocnemum macrostachyum. Plant Biol. 2010, 12, 79-87.
2. Ksouri, R.; Ksouri, W.M.; Jallali, I.; Debez, A.; Magné, C.; Hiroko, I.; Abdelly, C. Medicinal halophytes: Potent source of health promoting biomolecules with medical, nutraceutical and food applications. Crit. Rev. Biotechnol. 2012, 32, 289-326.
3. Menezes-Benavente, L.; Teixeira, F.K.; Kamei, C.L.A.; Margis-Pinheiro, M. Salt stress induces altered expression of genes encoding antioxidant enzymes in seedlings of a Brazilian indica rice (Oryza. sativa L.). Plant Sci. 2004, 166, 323-331.
4. Ben Amor, N.; Jiménez, A.; Megdiche, W.; Lundqvist, M.; Sevilla, F.; Abdelly, C. Response of antioxidant systems to NaCl stress in the halophyte Cakile maritima. Physiol. Plant. 2006, 126, 446-457.
5. Jaleel, C.A.; Manivannan, P.; Whid, A.; Farooq, M.; Al-Juburi, H.J.; Somasundaram, R.; Panneerselvam, R. Drought stress in plants: A review on morphological characteristics and pigments composition. Int. J. Agric. Biol. 2009, 11, 100-105.
6. Flowers, T.J.; Galal, H.K.; Bromham, L. Evolution of halophytes: Multiple origins of salt tolerance in land plants. Funct. Plant Biol. 2010, 37, 604-612.
7. Van der Watt, E.; Pretorius, J.C. Purification and identification of active antibacterial components in Carpobrotus edulis L. J. Ethnopharmacol. 2001, 76, 87-91.
8. Thring, T.S.A.; Weitz, F.M. Medicinal plant use in the Bredasdorp/Elim region of the Southern Overberg in the Western Cape Province of South Africa. J. Ethnopharmacol. 2006, 103, 261-275.
9. Bouftira, I.; Abdelly, C.; Sfar, S. Identification of a naturally occurring 2, 6-bis (1,1-dimethylethyl)-4-methylphenol from purple leaves of the halophyte plant Mesembryanthemum crystallinum. Afr. J. Biotechnol. 2007, 6, 1136-1139.
10. Falleh, H.; Ksouri, R.; Medini, F.; Guyot, S.; Abdelly, C.; Magné, C. Antioxidant activity and phenolic composition of the medicinal and edible halophyte Mesembryanthemum edule L. Ind. Crops Prod. 2011, 34, 1066-1071.
11. Falleh, H.; Jalleli, I.; Ksouri, R.; Boulaaba, M.; Guyot, S.; Magné, C.; Abdelly, C. Effect of salt treatment on phenolic compounds and antioxidant activity of two Mesembryanthemum edule provenances. Plant Physiol. Biochem. 2012, 52, 1-8.
12. Custódio, L.; Ferreira, A.C.; Pereira, H.; Silvestre, L.; Vizetto-Duarte, C.; Barreira, L.; Rauter, A.P.; Alberício, F.; Varela, J. The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities. Bot. Mar. 2012, 55, 281-288.
13. Awaad, A.S. Phenolic glycosides of Juncus acutus and its anti-eczematic activity. Chem. Nat. Compd. 2006 , 42, 152-155.
14. Behery, F.A.; Naeema, Z.E.; Maatooq, G.T.; Amer, M.M.; Ahmed, A.F. A novel antioxidant phenanthrenoid dimer from Juncus acutus L. Nat. Prod. Res. 2013, 27, 155-163.
15. El-Wahab, R.H.A.; Zaghloul, M.S.; Kamel, W.M.; Moustafa, A.R.A. Diversity and distribution of medicinal plants in North Sinai, Egypt. Afr. J. Environ. Sci. Technol. 2008, 2, 157-171.
16. Benzarti, M.; Rejeb, K.B.; Debez, A.; Messedi, D.; Abdelly, C. Photosynthetic activity and leaf antioxidative responses of Atriplex portulacoides subjected to extreme salinity. Acta Physiol. Plant. 2012, 34, 1679-1688.
17. Grossi, V.; Raphel, D. Long-chain (C-19-C-29) 1-chloro-n-alkanes in leaf waxes of halophytes of the Chenopodiaceae. Phytochemistry 2003, 63, 693-698.
18. Oliveira, V.; Santos, A.L.; Aguiar, C.; Santos, L.; Salvador, A.C.; Gomes, N.C.M.; Silva, H.; Rocha, S.M.; Almeida, A.; Cunha, A. Prokaryotes in salt marsh sediments of Ria de Aveiro: Effects of halophyte vegetation on abundance and diversity. Estuar. Coast. Shelf Sci. 2012, 110, 61-68.
19. Vilela, C.; Santos, S.A.O.; Coelho, D.; Silva, A.M.S.; Freire, C.S.R.; Neto, C.P.; Silvestre, A.J.D. Screening of lipophilic and phenolic extractives from different morphological parts of Halimione portulacoides. Ind. Crop. Prod. 2014, 32, 373-379.
20. Trabelsi, N.; Falleh, H.; Inès, J.; Daly, A.B.; Hajlaoui, H.; Smaoui, A.; Abdelly, C.; Ksouri, R. Variation of phenolic composition and biological activities in Limoniastrum monopetalum L. organs. Acta Physiol. Plant. 2012, 34, 87-96.
21. Trabelsi, N.; Waffo-Téguo, P.; Snoussi, M.; Ksouri, R.; Mérillon, J.M.; Smaoui, A.; Abdelly, C. Variability of phenolic composition and biological activities of two Tunisian halophyte species from contrasted regions. Acta Physiol. Plant. 2013, 35, 749-761.
22. Conforti, F.; Sosa, S.; Marrelli, M.; Menichini, F.; Statti, G.A.; Uzunov, D.; Tubaro, A.; Menichini, F.; Loggia, R.D. In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. J. Ethnopharmacol. 2008, 116, 144-151.
23. Meot-Duros, L.; Le Floch, G.; Magné, C. Radical scavenging, antioxidant and antimicrobial activities of halophytic species. J. Ethnopharmacol. 2008, 116, 258-262.
24. Kubes, P.; McCafferty, D.M. Nitric oxide and intestinal inflammation. Am. J. Med. 2000, 109, 150-158.
25. Beara, I.N.; Lesjak, M.M.; Orčić, D.Z.; Simin, N.Crossed D sign.; Četojević-Simin, D.D.; Božin, B.N.; Mimica-Dukić, N.M. Comparative analysis of phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of two closely-related Plantain species: Plantago altissima L. and Plantago lanceolata L. LWT Food Sci. Technol. 2012, 47, 64-70.
26. Ordway, D.; Hohmann, J.; Viveiros, M.; Viveiros, A.; Leandro, C.; Arroz, M.J.; Gracio, M.A.; Amaral, L. Carpobrotus edulis methanol extract inhibits the MDR efflux pumps, enhances killing of phagocytosed S. aureus and promotes immune modulation. Phytother. Res. 2003, 17, 512-519.
27. Martins, M.; Ordway, D.; Kristiansen, M.; Viveiros, M.; Leandro, C.; Molnar, J.; Amaral, L. Inhibition of the Carpobrotus. edulis methanol extract on the growth of phagocytosed multidrug-resistant Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus. Fitoterapia 2005, 76, 96-99.
28. Graham, J.G.; Quinn, M.L.; Fabricant, D.S.; Farnsworth, N.R. Plants used against cancer - An extension of the work of Jonathan Hartwell. J. Ethnopharmacol. 2000, 73, 347-377.
29. Gálvez, M; Martín-Cordero, C.; López-Lázaro, M.; Cortés, F.; Ayuso, M.J. Cytotoxic effect of Plantago. spp. on cancer cell lines. J. Ethnopharmacol. 2003, 88, 125-130.
30. Martins, A.; Vasas, A.; Schelz, Z.; Viveiros, M.; Molnár, J.; Hohmann, J.; Amaral, L. Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells. Anticancer Res. 2010, 30, 829-835.
31. El-Shamy, A.I.; Abdel-Razek, A.F.; Nassar, M.I. Phytochemical review of Juncus L. genus (Fam. Juncaceae). Arab. J. Chem. 2012, doi:10.1016/j.arabjc. 2012.07.007.
32. Martinez-Lirola, M.J.; Gonzalez-Tejero, M.R.; Molero-Mesa, J. Ethnobotanical resources in the province of Almeria, Spain, Campos De Nijar. Econ. Bot. 1996, 50, 40-56.
33. Behery, F.A.; Naeem, Z.E.; Maatooq, G.T.; Amer, M.M.; Wen, Z.H.; Sheu, J.H.; Ahmed, A.F. Phenanthrenoids from Juncus acutus L., new natural lipopolysaccharide-inducible nitric oxide synthase inhibitors. Chem. Pharm. Bull. 2007, 55, 1264-1266.
34. Miles, H.D.; Bhattacharyya, J.; Mody, J.L.; Atwood, S.B.; Hedin, P.A. The structure of juncusol. A novel cytotoxic dihydrophenanthrene from estuarine marsh plant Juncus roemerianus. J. Am. Chem. Soc. 1977, 99, 618-620.
35. Dos Santos Júnior, H.M.; Oliveira, D.; de Carvalho, D.A.; Pinto, J.; Campos, V.; Mourão, A.; Pessoa, C.; de Moraes, M.O.; Costa-Lotufo, L.V. Evaluation of native and exotic Brazilian plants for anticancer activity. J. Nat. Med. 2010, 64, 231-238.
36. Della Greca, M.; Fiorentino, A.; Mangoni, L.; Molinaro, A.; Monaco, P.; Previtera, L. 9,10-dihydrophenanthrene metabolites from Juncus effusus L. Tetrahedron Lett. 1992, 33, 5257-5260.
37. Della Greca, M.; Fiorentino, A.; Mangoni, A.; Molinaro, A.; Monaco, P.; Previtera, L. A bioactive dihydrodibenzoxepin from Juncus effusus. Phytochemistry 1993, 34, 1182-1184.
38. DellaGreca, M.; Isidori, M.; Lavorgna, M.; Monaco, P.; Previtera, L.; Zarrelli, A. Bioactivity of phenanthrenes from Juncus acutus on Selenastrum capricornutum. J. Chem. Ecol. 2004, 30, 867-879.
39. Sarkar, H.; Zerezghi, M.; Bhattacharyya, J. Dehydrojuncusol, a constituent of the roots of Juncus roemerianus. Phytochemistry 1988, 27, 3006-3008.
40. Brand-Williams, W.; Cuvelier, M.; Berset, C. Use of a free radical method to evaluate antioxidant activity. LWT Food Sci. Technol. 1995, 28, 25-30.
41. Moreno, S.; Scheyer, T.; Romano, C.S.; Vojnov, A.A. Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic. Res. 2006; 40, 223-231.
42. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 1999, 26, 1231-1237.
43. Velioglu, Y.S.; Mazza, G.; Gao, L.; Oomah, B.D. Antioxidant activity and total phenolics in selected fruits, vegetables and grain products. J. Agric. Food Chem. 1998, 46, 4113-4117.
44. Nishishiro, M.; Arikawa, S.; Wakabayashi, H.; Hashimoto, K.; Saton, K.; Yokoyama, K.; Unten, S.; Kakuta, H.; Kurihara, T.; Motohashi, N.; et al. Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenequinones. Anticancer Res. 2005, 25, 4157-4163.
45. Miranda, K.M.; Espey, M.G.; Wink, D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001, 5, 62-71.
46. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
47. Oh, S.H.; Ahn, J.; Kang, D.H.; Lee, H.Y. The effect of ultrasonificated extracts of Spirulina maxima on the anticancer activity. Mar. Biotechnol. 2011, 13, 205-214.
48. Liu, Y.; Zhao, C.; Li, H.; Yu, M.; Gao, J.; Wang, L.; Zhai, Y. Cytotoxicity and apoptosis induced by a new podophyllotoxin glucoside in human hepatoma (HepG2) cells. Can. J. Physiol. Pharmacol. 2010, 88, 472-479.