Cytotoxicity and apoptosis induced by a new podophyllotoxin glucoside in human hepatoma (HepG2) cells

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 4, 2010, Pages 472-479

  Liu, Yanfeng ^a,b,c   Zhao, Changqi ^b,c   Li, Hongxing ^b,c   Yu, Miao ^a,c   Gao, Jiali ^a,c   Wang, Lei ^d   Zhai, Yonggong ^a,b,c  

^a Beijing Key Laboratory of Engineered Drug   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c BEIJING NORMAL UNIVERSITY   (China)

^d General Hospital of the Second Artillery Force   (China)

Author keywords

Apoptosis; Bax; Bcl 2; HepG2; Podophyllotoxin

Indexed keywords

4 NOREPIPODOPHYLLOTOXIN 7' O BETA DEXTRO GLUCOPYRANOSIDE; 4 NORPICROPODOPHYLLOTOXIN 7' O BETA DEXTRO GLUCOPYRANOSIDE; ETOPOSIDE; GLUCOPYRANOSIDE; PODOPHYLLOTOXIN DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; 4-DEMETHYL-PICROPODOPHYLLOTOXIN 7'-O-GLUCOPYRANOSIDE; ANTINEOPLASTIC AGENT; GLUCOSIDE; PODOPHYLLOTOXIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG MECHANISM; DRUG STRUCTURE; FLOW CYTOMETRY; HEPATOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RHIZOME; SINOPODOPHYLLUM EMODI; ANALOGS AND DERIVATIVES; CELL DEATH; CELL SHAPE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HEPG2 CELL LINE; ISOLATION AND PURIFICATION; METABOLISM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; CELL SHAPE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSIDES; HEP G2 CELLS; HUMANS; PODOPHYLLOTOXIN; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 77952031335     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y10-008     Document Type: Article

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