Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells

Biochemical and Biophysical Research Communications

Volumn 447, Issue 4, 2014, Pages 569-573

  Aw, Darius Kang Lie ^a   Sinha, Rohit A ^a   Xie, Sherwin Ying ^a   Yen, Paul M ^a,b  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenosine monophosphate activated kinase; Glucagon; Insulin; Liver; Metformin; Protein kinase A

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCAGON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; METFORMIN; PROTEIN KINASE B; SERINE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRACELLULAR SIGNALING; LIVER CELL; PRIORITY JOURNAL; REDUCTION; REGULATORY MECHANISM;

ADENOSINE MONOPHOSPHATE ACTIVATED KINASE; GLUCAGON; INSULIN; LIVER; METFORMIN; PROTEIN KINASE A;

AMP-ACTIVATED PROTEIN KINASES; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE KNOCKDOWN TECHNIQUES; GLUCAGON; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; METFORMIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84900438062     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.031     Document Type: Article

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