The marine fungal metabolite, dicitrinone B, inducesA375 cell apoptosis through the ROS-related caspase pathway

Marine Drugs

Volumn 12, Issue 4, 2014, Pages 1939-1958

  Chen, Li ^a   Gong, Mei Wei ^a   Peng, Zhen Fei ^a   Zhou, Tong ^a   Ying, Min Gang ^b   Zheng, Qiu Hong ^b   Liu, Qin Ying ^b   Zhang, Qi Qing ^a,c  

^a FUZHOU UNIVERSITY   (China)

^b FUJIAN PROVINCIAL TUMOR HOSPITAL   (China)

^c INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

Author keywords

Anticancer activity; Apoptosis; Dicitrinone B; Human malignant melanoma cell A375; Marine derived fungus

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; DICITRINONE B; FLUOROURACIL; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE INHIBITOR; CITRININ;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL LINE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME ACTIVATION; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CANCER; LUNG CANCER; LYMPHOMA CELL; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PENICILLIUM CITRINUM; PROTEIN CLEAVAGE; STOMACH CANCER; ANALOGS AND DERIVATIVES; COMPARATIVE STUDY; DRUG EFFECTS; ISOLATION AND PURIFICATION; MELANOMA; METABOLISM; PATHOLOGY; PENICILLIUM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE INHIBITORS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CITRININ; FLUOROURACIL; HUMANS; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; PENICILLIUM; REACTIVE OXYGEN SPECIES;

EID: 84900434198     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12041939     Document Type: Article

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