MiR-202 suppresses cell proliferation in human hepatocellular carcinoma by downregulating LRP6 post-transcriptionally

FEBS Letters

Volumn 588, Issue 10, 2014, Pages 1913-1920

  Zhang, Yi ^a   Zheng, Dayong ^c   Xiong, Yan ^a   Xue, Chengbiao ^a   Chen, Gen ^a   Yan, Bibo ^a   Ye, Qifa ^a,b  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; lipoprotein receptor related protein 6; microRNA 202; Proliferation

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; MICRORNA; MICRORNA 202; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CARCINOGENICITY; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; LIVER CELL CARCINOMA; LRP6 GENE; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; SIGNAL TRANSDUCTION; TUMOR GENE;

HEPATOCELLULAR CARCINOMA; LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6; MICRORNA-202; PROLIFERATION;

3' UNTRANSLATED REGIONS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER;

EID: 84900418890     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.03.030     Document Type: Article

References (28)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J. Clin. 61 2011 69 90
2. V.T. Nguyen, M.G. Law, and G.J. Dore Hepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden J. Viral. Hepat. 16 2009 453 463
3. S. Jelic, and G.C. Sotiropoulos Hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up Ann. Oncol. 21 Suppl 5 2010 v59 64
4. V. Ambros The functions of animal microRNAs Nature 431 2004 350 355
5. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
6. J.P. Hagan, and C.M. Croce MicroRNAs in carcinogenesis Cytogenet. Genome Res. 118 2007 252 259
7. G.A. Calin, and C.M. Croce MicroRNA signatures in human cancers Nat. Rev. Cancer 6 2006 857 866
8. T.A. Farazi, J.I. Hoell, P. Morozov, and T. Tuschl MicroRNAs in human cancer Adv. Exp. Med. Biol. 774 2013 1 20
9. S.L. Peiffer, T.J. Herzog, D.J. Tribune, D.G. Mutch, D.J. Gersell, and P.J. Goodfellow Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers Cancer Res. 55 1995 1922 1926
10. S.H. Lee, J.A. Davison, S.M. Vidal, and A. Belouchi Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors Mamm. Genome 12 2001 157 162
11. W. Courtens, W. Wuyts, L. Rooms, S.B. Pera, and J. Wauters A subterminal deletion of the long arm of chromosome 10: a clinical report and review Am. J. Med. Genet. A 140 2006 402 409
12. Y. Zhao, C. Li, M. Wang, L. Su, Y. Qu, J. Li, B. Yu, M. Yan, Y. Yu, and B. Liu Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer PLoS ONE 8 2013 e69756
13. M.V. Iorio, M. Ferracin, C.G. Liu, A. Veronese, R. Spizzo, S. Sabbioni, E. Magri, M. Pedriali, M. Fabbri, and M. Campiglio et al. MicroRNA gene expression deregulation in human breast cancer Cancer Res. 65 2005 7065 7070
14. Y. Zhang, Y. Dai, Y. Huang, L. Ma, Y. Yin, M. Tang, and C. Hu Microarray profile of micro-ribonucleic acid in tumor tissue from cervical squamous cell carcinoma without human papillomavirus J. Obstet. Gynaecol. Res. 35 2009 842 849
15. E.K. Ng, W.W. Chong, H. Jin, E.K. Lam, V.Y. Shin, J. Yu, T.C. Poon, S.S. Ng, and J.J. Sung Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening Gut 58 2009 1375 1381
16. A.E. Hoffman, R. Liu, A. Fu, T. Zheng, F. Slack, and Y. Zhu Targetome profiling, pathway analysis and genetic association study implicate miR-202 in lymphomagenesis Cancer Epidemiol. Biomarkers Prev. 22 2013 327 336
17. S.D. Brown, R.C. Twells, P.J. Hey, R.D. Cox, E.R. Levy, A.R. Soderman, M.L. Metzker, C.T. Caskey, J.A. Todd, and J.F. Hess Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family Biochem. Biophys. Res. Commun. 248 1998 879 888
18. Y. Li, W. Lu, X. He, A.L. Schwartz, and G. Bu LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution Oncogene 23 2004 9129 9135
19. C.C. Liu, J. Prior, D. Piwnica-Worms, and G. Bu LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy Proc. Natl. Acad. Sci. USA 107 2010 5136 5141
20. E.K. Tung, B.Y. Wong, T.O. Yau, and I.O. Ng Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion PLoS ONE 7 2012 e36565
21. R. Wei, G.L. Huang, M.Y. Zhang, B.K. Li, H.Z. Zhang, M. Shi, X.Q. Chen, L. Huang, Q.M. Zhou, and W.H. Jia et al. Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma Clin. Cancer Res. 19 2013 4780 4791 10.1158/1078-0432.CCR-12-2728-0432.CCR-12-2728 [pii]
22. W.C. Hahn, S.K. Dessain, M.W. Brooks, J.E. King, B. Elenbaas, D.M. Sabatini, J.A. DeCaprio, and R.A. Weinberg Enumeration of the simian virus 40 early region elements necessary for human cell transformation Mol. Cell. Biol. 22 2002 2111 2123
23. A. Esquela-Kerscher, and F.J. Slack Oncomirs - microRNAs with a role in cancer Nat. Rev. Cancer 6 2006 259 269
24. J. Buechner, E. Tomte, B.H. Haug, J.R. Henriksen, C. Lokke, T. Flaegstad, and C. Einvik Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma Br. J. Cancer 105 2011 296 303
25. H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
26. C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu. Rev. Cell Dev. Biol. 20 2004 781 810
27. X. He, M. Semenov, K. Tamai, and X. Zeng LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way Development 131 2004 1663 1677
28. K. Tamai, M. Semenov, Y. Kato, R. Spokony, C. Liu, Y. Katsuyama, F. Hess, J.P. Saint-Jeannet, and X. He LDL-receptor-related proteins in Wnt signal transduction Nature 407 2000 530 535