Structural basis of sialidase in complex with geranylated flavonoids as potent natural inhibitors

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 5, 2014, Pages 1357-1365

  Lee, Youngjin ^a   Ryu, Young Bae ^b   Youn, Hyung Seop ^a   Cho, Jung Keun ^c   Kim, Young Min ^b   Park, Ji Young ^b   Lee, Woo Song ^b   Park, Ki Hun ^c   Eom, Soo Hyun ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

diplacone; geranylated flavonoid; NanI; sialidase; sialidase inhibitor

Indexed keywords

ENZYME INHIBITOR; FLAVANONE DERIVATIVE; FLAVONOID; SIALIDASE;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CLOSTRIDIUM PERFRINGENS; ENZYME ACTIVE SITE; ENZYMOLOGY; IC50; KINETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CLOSTRIDIUM PERFRINGENS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FLAVANONES; FLAVONOIDS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, MOLECULAR; NEURAMINIDASE; PROTEIN CONFORMATION;

EID: 84900402089     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004714002971     Document Type: Article

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