N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans

PLoS Pathogens

Volumn 6, Issue 3, 2010, Pages

  Huang, Guanghua ^a   Yi, Song ^a   Sahni, Nidhi ^a   Daniels, Karla J ^a   Srikantha, Thyagarajan ^a   Soll, David R ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GENE PRODUCT; MONOSACCHARIDE; N ACETYLGLUCOSAMINE; PROTEIN RAS1; PROTEIN WOR1; UNCLASSIFIED DRUG; ADENYLATE CYCLASE; CARBON DIOXIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2; FUNGAL PROTEIN; RAS PROTEIN;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; GENE LOCUS; GENE SWITCHING; GENETIC REGULATION; INTESTINE FLORA; MATING; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; FUNGAL GENE; GASTROINTESTINAL TRACT; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REGULATOR GENE; TEMPERATURE;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS;

ACETYLGLUCOSAMINE; ADENYLATE CYCLASE; CANDIDA ALBICANS; CARBON DIOXIDE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2; FUNGAL PROTEINS; GASTROINTESTINAL TRACT; GENES, MATING TYPE, FUNGAL; GENES, SWITCH; PHOSPHORYLATION; RAS PROTEINS; SIGNAL TRANSDUCTION; TEMPERATURE;

EID: 77950456763     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000806     Document Type: Article

References (54)

1. Soll DR (1992) High-frequency switching in Candida albicans. Clin Microbiol Rev 5: 183-203.
2. Soll DR (2009) Why does Candida albicans switch? FEMS Yeast 9: 973-989
3. Lan CY, Newport G, Murillo LA, Jones T, Scherer S, et al. (2002) Metabolic specialization associated with phenotypic switching in Candida albicans. Proc Natl Acad Sci U S A 99: 14907-14912. (Pubitemid 35334583)
4. Miller MG, Johnson AD (2002) White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110: 293-302.
5. Huang G, Wang H, Chou S, Nie X, Chen J, et al. (2006) Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans. Proc Natl Acad Sci U S A 103: 12813-12818. (Pubitemid 44298644)
6. Srikantha T, Borneman AR, Daniels KJ, Pujol C, Wu W, et al. (2006) TOS9 regulates white-opaque switching in Candida albicans. Eukaryot Cell 5: 1674-1687. (Pubitemid 44641710)
7. Zordan RE, Galgoczy DJ, Johnson AD (2006) Epigenetic properties of white-opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback loop. Proc Natl Acad Sci U S A 103: 12807-12812.
8. Zordan RE, Miller MG, Galgoczy DJ, Tuch BB, Johnson AD (2007) Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans. PLoS Biol 5(10): e256. doi:10.1371/journal.pbio.0050256.
9. Vinces MD, Kumamoto CA (2007) The morphogenetic regulator Czf1p is a DNA-binding protein that regulates white opaque switching in Candida albicans. Microbiology 153: 2877-2884.
10. Klar AJ, Srikantha T, Soll DR (2001) A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. Genetics 158: 919-924. (Pubitemid 32552326)
11. Srikantha T, Tsai L, Daniels K, Klar AJ, Soll DR (2001) The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans. J Bacteriol 183: 4614-4625. (Pubitemid 32646012)
12. Hnisz D, Schwarzmuller T, Kuchler K (2009) Transcriptional loops meet chromatin: a dual-layer network controls white-opaque switching in Candida albicans. Mol Microbiol 74: 1-15.
13. Hull CM, Johnson AD (1999) Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285: 1271-1275.
14. Lockhart SR, Pujol C, Daniels KJ, Miller MG, Johnson AD, Pfaller MA, Soll DR (2002) In Candida albicans, white-opaque switchers are homozygous for mating type. Genetics 162: 737-745.
15. Slutsky B, Staebell M, Anderson J, Risen L, Pfaller M, Soll DR (1987) "White-opaque transition": a second high-frequency switching system in Candida albicans. J Bacteriol 169: 189-197.
16. Rikkerink EH, Magee BB, Magee PT (1988) Opaque-white phenotype transition: a programmed morphological transition in Candida albicans. J Bacteriol 170: 895-899.
17. Srikantha T, Soll DR (1993) A white-specific gene in the white-opaque switching system of Candida albicans. Gene 131: 53-60.
18. Huang G, Srikantha T, Sahni N, Yi S, Soll DR (2009) CO2 regulates white-to-opaque switching in Candida albicans. Curr Biol 19: 330-334. (Pubitemid 44641710)
19. Mock RC, Pollack JH, Hashimoto T (1990) Carbon dioxide induces endotrophic germ tube formation in Candida albicans. Can J Microbiol 36: 249-253.
20. 2 sensing with cAMP signaling and virulence. Curr Biol 15: 2021-2026.
21. Ghuysen J.-M, Hakenbeck R (1994) Bacterial cell wall. Amsterdam: Elsevier.581 p.
22. Simonetti N, Strippoli V, Cassone A (1974) Yeast-mycelial conversion induced by N-acetyl-D-glucosamine in Candida albicans. Nature 250: 344-346.
23. Cho T, Hamatake H, Kaminishi H, Hagihara Y, Watanabe K (1992) The relationship between cyclic adenosine 3′,5′-monophosphate and morphology in exponential phase Candida albicans. J Med Vet Mycol 30: 35-42.
24. Cassone A, Sullivan PA, Shepherd MG (1985) N-acetyl-D-glucosamine-induced morphogenesis in Candida albicans. Microbiologica 8: 85-99.
25. Feng Q, Summers E, Guo B, Fink G (1999) Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J Bacteriol 181: 6339-6346. (Pubitemid 29512943)
26. Rocha CR, Schroppel K, Harcus D, Marcil A, Dignard D, et al. (2001) Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol Biol Cell 12: 3631-3643. (Pubitemid 33108492)
27. Bockmühl DP, Krishnamurthy S, Gerads M, Sonneborn A, Ernst JF (2001) Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans. Mol Microbiol 42: 1243-1257. (Pubitemid 34209086)
28. Castilla R, Passeron S, Cantore ML (1998) N-acetyl-D-glucosamine induces germination in Candida albicans through a mechanism sensitive to inhibitors of cAMP-dependent protein kinase. Cell Signal 10: 713-719. (Pubitemid 28520023)
29. Bahn YS, Molenda M, Staab JF, Lyman CA, Gordon LJ, et al. (2007) Genome-wide transcriptional profiling of the cyclic AMP-dependent signaling pathway during morphogenic transitions of Candida albicans. Eukaryot Cell 6: 2376-2390.
30. Wilson D, Tutulan-Cunita A, Jung W, Hauser NC, Hernandez R, et al. (2007) Deletion of the high-affinity cAMP phosphodiesterase encoded by PDE2 affects stress responses and virulence in Candida albicans. Mol Microbiol 65: 841-856. (Pubitemid 47221068)
31. Bedell GW, Soll DR (1979) Effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: evidence for zinc-resistant and -sensitive pathways for mycelium formation. Infect Immun 26: 348-354.
32. Bergen MS, Voss E, Soll DR (1990) Switching at the cellular level in the white-opaque transition of Candida albicans. J Gen Microbiol 136: 1925-1936.
33. Care RS, Trevethick J, Binley KM, Sudbery PE (1999) The MET3 promoter: a new tool for Candida albicans molecular genetics. Mol Microbiol 34: 792-798.
34. Bahn YS, Staab J, Sundstrom P (2003) Increased high-affinity phosphodiesterase PDE2 gene expression in germ tubes counteracts CAP1-dependent synthesis of cyclic AMP, limits hypha production and promotes virulence of Candida albicans. Mol Microbiol 50: 391-409. (Pubitemid 37297123)
35. Jung WH, Stateva LI (2003) The cAMP phosphodiesterase encoded by CaPDE2 is required for hyphal development in Candida albicans. Microbiology 149: 2961-2976.
36. Pan X, Harashima T, Heitman J (2000) Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol 3: 567-572.
37. Nikawa J, Cameron S, Toda T, Ferguson KM, Wigler M (1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev 1: 931-937.
38. Cloutier M, Castilla R, Bolduc N, Zelada A, Martineau P, et al. (2003) The two isoforms of the cAMP-dependent protein kinase catalytic subunit are involved in the control of dimorphism in the human fungal pathogen Candida albicans. Fungal Genet Biol 38: 133-141. (Pubitemid 36262920)
39. Sahni N, Yi S, Daniels KJ, Srikantha T, Pujol C, et al. (2009) Genes Selectively Up-Regulated by Pheromone in White Cells Are Involved in Biofilm Formation in Candida albicans. PLoS Pathog 5(10): e1000601. doi:10.1371/journal. ppat.1000601.
40. Levitt MD, Bond JH, Jr. (1970) Volume, composition, and source of intestinal gas. Gastroenterology 59: 921-929.
41. Avunduk C (2002) Manual of Gastroenterology: Diagnosis and Therapy. Philadelphia: Lippincott Williams & Wilkins. 505 p.
42. O'Hara AM, Shanahan F (2006) The gastrointestinal tract flora as a forgotten organ. EMBO Rep 7: 688-693.
43. Chen J, Chen J, Lane S, Liu H (2002) A conserved mitogen-activated protein kinase pathway is required for mating in Candida albicans. Mol Microbiol 46: 1335-1344. (Pubitemid 36961267)
44. Caspari T (1997) Onset of gluconate-H+ symport in Schizosaccharomyces pombe is regulated by the kinases Wis1 and Pka1, and requires the gti1+ gene product. J Cell Sci 110: 2599-2608.
45. Madhani HD, Fink GR (1998) The control of filamentous differentiation and virulence in fungi. Trends Cell Biol 8: 348-353. (Pubitemid 28398425)
46. Anderson JM, Soll DR (1987) Unique phenotype of opaque cells in the white-opaque transition of Candida albicans. J Bacteriol 169: 5579-5588.
47. Anderson J, Mihalik R, Soll DR (1990) Ultrastructure and antigenicity of the unique cell wall pimple of the Candida opaque phenotype. J Bacteriol 172: 224-235.
48. Pujol C, Daniels KJ, Lockhart SR, Srikantha T, Radke JB, et al. (2004) The closely related species Candida albicans and Candida dubliniensis can mate. Eukaryot Cell 3: 1015-1027. (Pubitemid 39098877)
49. Wilson RB, Davis D, Enloe BM, Mitchell AP (2000) A recyclable Candida albicans URA3 cassette for PCR product-directed gene disruptions. Yeast 16: 65-70. (Pubitemid 30066097)
50. Strauss A, Michel S, Morschhäuser J (2001) Analysis of phase-specific gene expression at the single-cell level in the white-opaque switching system of Candida albicans. J Bacteriol 183: 3761-3769. (Pubitemid 32510444)
51. Wilson RB, Davis D, Mitchell AP (1999) Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J Bacteriol 181: 1868-1874. (Pubitemid 29138620)
52. Park YN, Morschhüuser J (2005) Tetracycline-inducible gene expression and gene deletion in Candida albicans. Eukaryot Cell 4: 1328-1342. (Pubitemid 41176687)
53. Ke SH, Madison EL (1997) Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method. Nucleic Acids Res 25: 3371-3372.
54. Yi S, Sahni N, Pujol C, Daniels KJ, Srikantha T, et al. (2009) A Candida albicans-specific region of the alpha-pheromone receptor plays a selective role in the white cell pheromone response. Mol Microbiol 71: 925-947.