Roles of Candida albicans Gat2, a GATA-type zinc finger transcription factor, in biofilm formation, filamentous growth and virulence

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Du, Han ^a   Guan, Guobo ^a   Xie, Jing ^a,b   Sun, Yuan ^a   Tong, Yaojun ^a,b   Zhang, Lixin ^a   Huang, Guanghua ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; N ACETYLGLUCOSAMINE; PLASTIC; SILICON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CPH1; TRANSCRIPTION FACTOR GAT2; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR TEC1; TRANSCRIPTION FACTOR UME6; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; FUNGAL PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOFILM; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; CULTURE MEDIUM; FILAMENTOUS ALGA; FUNGAL GENE; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS HYPHAE; GAT2 GENE; GENE DELETION; GENE OVEREXPRESSION; LEE MEDIUM; MOLECULAR LIBRARY; MOUSE; MUTANT; NONHUMAN; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SYSTEMIC DISEASE; TRANSCRIPTION REGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; VIRULENCE;

CANDIDA ALBICANS;

ANIMALS; BIOFILMS; CANDIDA ALBICANS; CANDIDIASIS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HYPHAE; MALE; MICE; TRANSCRIPTION FACTORS; VIRULENCE; ZINC FINGERS;

EID: 84855998530     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029707     Document Type: Article

References (28)

1. Pfaller MA, Diekema DJ, (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20: 133-163.
2. Whiteway M, Bachewich C, (2007) Morphogenesis in Candida albicans. Annu Rev Microbiol 61: 529-553.
3. Lo HJ, Kohler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, et al. (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949.
4. Cottier F, Muhlschlegel FA, (2009) Sensing the environment: response of Candida albicans to the X factor. FEMS Microbiol Lett 295: 1-9.
5. Yi S, Sahni N, Daniels KJ, Lu KL, Srikantha T, et al. (2011) Alternative Mating Type Configurations (a/alpha versus a/a or alpha/alpha) of Candida albicans Result in Alternative Biofilms Regulated by Different Pathways. PLoS Biol 9: e1001117.
6. Csank C, Schroppel K, Leberer E, Harcus D, Mohamed O, et al. (1998) Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis. Infect Immun 66: 2713-2721.
7. Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, et al. (1996) Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci U S A 93: 13217-13222.
8. Liu H, Kohler J, Fink GR, (1994) Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726.
9. Ramage G, Saville SP, Thomas DP, Lopez-Ribot JL, (2005) Candida biofilms: an update. Eukaryot Cell 4: 633-638.
10. Finkel JS, Mitchell AP, (2011) Genetic control of Candida albicans biofilm development. Nat Rev Microbiol 9: 109-118.
11. Baillie GS, Douglas LJ, (1999) Role of dimorphism in the development of Candida albicans biofilms. J Med Microbiol 48: 671-679.
12. Banerjee M, Thompson DS, Lazzell A, Carlisle PL, Pierce C, et al. (2008) UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence. Mol Biol Cell 19: 1354-1365.
13. Ramage G, Saville SP, Wickes BL, Lopez-Ribot JL, (2002) Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl Environ Microbiol 68: 5459-5463.
14. Nobile CJ, Andes DR, Nett JE, Smith FJ, Yue F, et al. (2006) Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog 2: e63.
15. Sahni N, Yi S, Daniels KJ, Huang G, Srikantha T, et al. (2010) Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways. PLoS Biol 8: e1000363.
16. Park YN, Morschhauser J, (2005) Tetracycline-inducible gene expression and gene deletion in Candida albicans. Eukaryot Cell 4: 1328-1342.
17. Chen J, Lane S, Liu H, (2002) A conserved mitogen-activated protein kinase pathway is required for mating in Candida albicans. Mol Microbiol 46: 1335-1344.
18. Homann OR, Dea J, Noble SM, Johnson AD, (2009) A phenotypic profile of the Candida albicans regulatory network. PLoS Genet 5: e1000783.
19. Simonetti N, Strippoli V, Cassone A, (1974) Yeast-mycelial conversion induced by N-acetyl-D-glucosamine in Candida albicans. Nature 250: 344-346.
20. Huang G, Yi S, Sahni N, Daniels KJ, Srikantha T, et al. (2010) N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans. PLoS Pathog 6: e1000806.
21. Schweizer A, Rupp S, Taylor BN, Rollinghoff M, Schroppel K, (2000) The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Mol Microbiol 38: 435-445.
22. Lane S, Zhou S, Pan T, Dai Q, Liu H, (2001) The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via TEC1. Mol Cell Biol 21: 6418-6428.
23. Nobile CJ, Nett JE, Hernday AD, Homann OR, Deneault JS, et al. (2009) Biofilm matrix regulation by Candida albicans Zap1. PLoS Biol 7: e1000133.
24. Ramage G, VandeWalle K, Lopez-Ribot JL, Wickes BL, (2002) The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans. FEMS Microbiol Lett 214: 95-100.
25. MacIsaac KD, Wang T, Gordon DB, Gifford DK, Stormo GD, et al. (2006) An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics 7: 113.
26. Lane S, Birse C, Zhou S, Matson R, Liu H, (2001) DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans. J Biol Chem 276: 48988-48996.
27. Hnisz D, Tscherner M, Kuchler K, (2011) Morphological and molecular genetic analysis of epigenetic switching of the human fungal pathogen Candida albicans. Methods Mol Biol 734: 303-315.
28. Chen J, Zhou S, Wang Q, Chen X, Pan T, et al. (2000) Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans. Mol Cell Biol 20: 8696-8708.