Omega 3 chronic supplementation attenuates myocardial ischaemia-reperfusion injury through reinforcement of antioxidant defense system in rats

Cell Biochemistry and Function

Volumn 32, Issue 3, 2014, Pages 274-281

  Castillo, Rodrigo L ^a   Arias, Consuelo ^b   Farías, Jorge G ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD DE LA FRONTERA   (Chile)

Author keywords

Heart; Ischaemia reperfusion; Omega 3; Oxidative stress

Indexed keywords

CATALASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; ANTIOXIDANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; ENERGY CONSUMPTION; ENZYME ACTIVITY; EX VIVO STUDY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PERFORMANCE; HEART PROTECTION; LIPID PEROXIDATION; LONG TERM CARE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REINFORCEMENT; REPERFUSION INJURY; SUPPLEMENTATION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; DIET; HEART INFARCTION; HEMODYNAMICS; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PATHOPHYSIOLOGY;

RATTUS;

ANIMALS; ANTIOXIDANTS; DIET; FATTY ACIDS, OMEGA-3; HEMODYNAMICS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; RATS;

EID: 84900352303     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.3012     Document Type: Article

References (44)

1. Castillo R, Rodrigo R, Perez F, et al. Antioxidant therapy reduces oxidative and inflammatory tissue damage in patients subjected to cardiac surgery with extracorporeal circulation. Basic Clin Pharmacol Toxicol 2011; 108: 256-262.
2. Masson S, Marchioli R, Mozaffarian D, et al. Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-Heart Failure Trial: relation with fish intake, circulating biomarkers, and mortality. Am Heart J 2013; 165: 208-215.e4. DOI: 10.1016/j.ahj.2012.10.021
3. Zeghichi-Hamri S, de Lorgeril M, Salen P, et al. Protective effect of dietary n-3 polyunsaturated fatty acids on myocardial resistance to ischemia-reperfusion injury in rats. Nutr Res 2010; 30: 849-857. DOI:10.1016/j.nutres.2010.10.010.
4. Xie N, Zhang W, Li J, et al. α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. Arch Med Res 2011; 42: 171-81. DOI:10.1016/j.arcmed.2011.04.008.
5. Rodrigo R, Prieto JC, Castillo R. Cardioprotection against ischemia-reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical application. Clin Sci (Lond) 2013; 124: 1-15.
6. Rizos EC, Ntzani EE, Bik E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 2012; 308: 1024-33.
7. Khairallah RJ, Kim J, O'Shea KM, et al. Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. PLoS One 2012; 7: e34402. DOI:10.1371/journal.pone.0034402.
8. Gong P, Hu B, Cederbaum AI. Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch Biochem Biophys 2004; 432: 252-60.
9. Rondeau I, Picard S, Bah TM, Roy L, Godbout R, Rousseau G. Effects of different dietary omega-6/3 polyunsaturated fatty acids ratios on infarct size and the limbic system after myocardial infarction. Can J Physiol Pharmacol 2011; 89: 169-76.
10. Araya J, Rodrigo R, Orellana M, Rivera G. Red wine raises plasma HDL and preserves long-chain polyunsaturated fatty acids in rat kidney and erythrocytes. Br J Nutr 2001; 86: 189-195.
11. Collins TJ. ImageJ for microscopy. Biotechniques 2007; 43: 25-30.
12. Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976; 74: 214-226.
13. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358.
14. Nebot C, Moutet M, Huet P, Xu J, Yadan JC, Chaudiere J. Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol. Anal Biochem 1993; 14: 442-51.
15. Aebi H. Catalase, Methods in Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1974; 673-677.
16. Flohé L, Günzler WA. Assays of glutathione peroxidase. Methods Enzymol 1984; 105: 114-121.
17. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-1135.
18. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, Becker LB. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol 1997; 29: 2571-2583.
19. Zhang Y, Sano M, Shinmura K, et al. 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway. J Mol Cell Cardiol 2010; 49: 576-586. DOI:10.1016/j.yjmcc.2010.05.011.
20. Inserte J, Barrabés JA, Hernando V, Garcia-Dorado D. Orphan targets for reperfusion injury. Cardiovasc Res 2009; 83: 169-178. DOI:10.1093/cvr/cvp109.
21. Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 2007; 59: 418-458.
22. Adluri RS, Thirunavukkarasu M, Zhan L, et al. Cardioprotective efficacy of a novel antioxidant mix vitaepro against ex vivo myocardial ischemia-reperfusion injury. Cell Biochem Biophys 2011. [Epub ahead of print]. DOI: 10.1007/s12013-011-9300-7
23. Ibacache M, Sanchez G, Pedrozo Z, et al. Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart. Biochim Biophys Acta 1822; 2012: 537-545. DOI:10.1016/j.bbadis.2011.12.013.
24. Ahmed LA, Salem HA, Attia AS, Agha AM. Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury. Life Sci 2012; 90: 249-256. DOI:10.1016/j.lfs.2011.11.007.
25. Carnes CA, Janssen PM, Ruehr ML, et al. Atrial glutathione content, calcium current, and contractility. J Biol Chem 2007; 282: 28063-28073.
26. Mozaffarian D, Willett WC. Trans fatty acids and cardiovascular risk: a unique cardiometabolic imprint? Curr Atheroscler Rep 2007; 9: 486-493.
27. Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem 2010; 21: 781-792. DOI:10.1016/j.jnutbio.2009.12.004.
28. Cummings BP, Stanhope KL, Graham JL, Griffen SC, Havel PJ. Supplementation with EPA or fish oil for 11 months lowers circulating lipids, but does not delay the onset of diabetes in UC Davis-type 2 diabetes mellitus rats. Br J Nutr 2010; 104: 1628-1634. DOI:10.1017/S0007114510002655.
29. Karsenty J, Landrier JF, Rousseau-Ralliard D, et al. Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha. Eur J Nutr 2012. [Epub ahead of print]. DOI: 10.1007/s00394-012-0488-0
30. Kaur G, Sinclair AJ, Cameron-Smith D, Barr DP, Molero-Navajas JC, Konstantopoulos N. Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells. Prostaglandins Leukot Essent Fatty Acids 2011; 85: 155-161. DOI:10.1016/j.plefa.2011.06.002.
31. Kuang YL, Paulson KE, Lichtenstein AH, Lamon-Fava S. Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. Br J Nutr 2012; 108: 1351-9. DOI:10.1017/S0007114511006854.
32. Abdukeyum GG, Owen AJ, McLennan PL. Dietary (n-3) long-chain polyunsaturated fatty acids inhibit ischemia and reperfusion arrhythmias and infarction in rat heart not enhanced by ischemic preconditioning. J Nutr 2008; 138: 1902-9.
33. Erdogan H, Fadillioglu E, Ozgocmen S, et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 149-152.
34. Gao L, Wang J, Sekhar KR, et al. Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem 2007; 282: 2529-2537.
35. Jahangiri A, Leifert WR, Kind KL, McMurchie EJ. Dietary fish oil alters cardiomyocyte Ca2+ dynamics and antioxidant status. Free Radic Biol Med 2006; 40: 1592-1602.
36. Leaf A, Xiao YF, Kang JX, Billman GE. Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias. J Membr Biol 2005; 206: 129-39.
37. Chapkin RS, Wang N, Fan YY, Lupton JR, Prior IA. Docosahexaenoic acid alters the size and distribution of cell surface microdomains. Biochim Biophys Acta 2008; 1778: 466-71.
38. Kang JX, Xiao YF, Leaf A. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A 1995; 92: 3997-4001.
39. Brahmbhatt V, Oliveira M, Briand M, et al. Protective effects of dietary EPA and DHA on ischemia-reperfusion-induced intestinal stress. J Nutr Biochem 2013; 24: 104-11.
40. Engelbrecht AM, Engelbrecht P, Genade S, et al. Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway. J Mol Cell Cardiol 2005; 39: 940-954.
41. Force T, Malis CD, Guerrero JL, et al. n-3 fatty acids increase postischemic blood flow but do not reduce myocardial necrosis. J Physiol 1989; 257: H1204-H1210.
42. Pepe S, McLennan PL. Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function. Circulation 2002; 105: 2303-2308.
43. Ogita H, Node K, Asanuma H, et al. Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts. J Cardiovasc Pharmacol 2003; 41: 964-969.
44. Ramadeen A, Connelly KA, Leong-Poi H, et al. N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria. Heart Rhythm 2012; 9: 1115-1122.e4. DOI: 10.1016/j.hrthm.2012.02.013