Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Yao, Yixin ^a   Lu, Yinghua ^a   Chen, Wen Chi ^a   Jiang, Yongping ^b   Cheng, Tao ^c   Ma, Yupo ^d   Lu, Lou ^e   Dai, Wei ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^d STONY BROOK UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; COBALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; NICKEL; OCTAMER TRANSCRIPTION FACTOR 4; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NANOG;

ARTICLE; CHROMATIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; INTRACELLULAR SPACE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROCESSING; PROTEIN STABILITY; REPRODUCTIVE TOXICITY; STEM CELL; SUMOYLATION; UBIQUITINATION;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELLS, CULTURED; COBALT; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYSINE; MICE; MUTATION; NICKEL; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN PROCESSING, POST-TRANSLATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; SUMOYLATION; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; UBIQUITINATION;

EID: 84900341901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086620     Document Type: Article

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