Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

Journal of Medicinal Chemistry

Volumn 57, Issue 9, 2014, Pages 3818-3834

  Nilsen, Aaron ^a   Miley, Galen P ^a   Forquer, Isaac P ^a   Mather, Michael W ^b   Katneni, Kasiram ^c   Li, Yuexin ^a   Pou, Sovitj ^a   Pershing, April M ^b   Stickles, Allison M ^d   Ryan, Eileen ^c   Kelly, Jane Xu ^a   Doggett, J Stone ^a   White, Karen L ^c   Hinrichs, David J ^a   Winter, Rolf W ^a   Charman, Susan A ^c   Zakharov, Lev N ^e   Bathurst, Ian ^f   Burrows, Jeremy N ^f   Vaidya, Akhil B ^b   Riscoe, Michael K ^a,g   more..

^a PORTLAND VA MEDICAL CENTER   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c MONASH UNIVERSITY   (Australia)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF OREGON   (United States)

^f Medicines for Malaria Venture   (Switzerland)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; CHLOROQUINE; ELQ 233; ELQ 271; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG INDICATION; DRUG METABOLISM; DRUG SYNTHESIS; MALARIA; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DRUG DISCOVERY; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; QUINOLONES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84900336048     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500147k     Document Type: Article

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