Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown

Cellular and Molecular Life Sciences

Volumn 71, Issue 10, 2014, Pages 1927-1941

  Huber, P ^a,b,c,d   Bouillot, S ^a,b,c,d   Elsen, S ^a,b,c,d   Attree I ^a,b,c,d  

^a INSERM   (France)

^b CNRS   (France)

^c UNIV GRENOBLE ALPES   (France)

^d CEA GRENOBLE   (France)

Author keywords

Actin; Endothelium; Host pathogen interaction; Nosocomial infection; Rho GTPases; Signaling pathways

Indexed keywords

BACTERIAL TOXIN; COFILIN; EXOS TOXIN; EXOT TOXIN; EXOY TOXIN; FOCAL ADHESION KINASE; LIM KINASE; MOESIN; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INACTIVATION; FOCAL ADHESION; MALE; MEMBRANE DAMAGE; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

ACTIN CYTOSKELETON; ADP RIBOSE TRANSFERASES; ANIMALS; BACTERIAL TOXINS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FOCAL ADHESIONS; GTPASE-ACTIVATING PROTEINS; HOST-PATHOGEN INTERACTIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIM KINASES; MALE; MICE; MICE, INBRED BALB C; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RHO GTP-BINDING PROTEINS;

EID: 84900331890     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1451-9     Document Type: Article

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