Disturbed synthesis of type II collagen interferes with rate of bone formation and growth and increases bone resorption in transgenic mice

Calcified Tissue International

Volumn 82, Issue 3, 2008, Pages 229-237

  Nieminen, Jyrki ^a   Sahlman, Janne ^b   Hirvonen, Teemu ^c   Lapveteläinen, Tuomo ^d   Miettinen, Markku ^e   Arnala, Ilkka ^f   Malluche, Hartmut H ^g   Helminen, Heikki J ^c  

^a Coxa Hospital for Joint Replacement ^*  (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d NATIONAL AGENCY FOR MEDICINES   (Finland)

^e ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^f KANTA HÄME CENTRAL HOSPITAL   (Finland)

^g UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Chondrodysplasia; COL2A1 deletion; Mouse; Transgenic; Vertebrate skeleton

Indexed keywords

COLLAGEN TYPE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTHROPOMETRY; ARTICLE; BODY WEIGHT; BONE DEVELOPMENT; BONE GROWTH; BONE MASS; BONE MINERALIZATION; BONE RADIOGRAPHY; CARTILAGE; CHONDRODYSPLASIA; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE DELETION; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOARTHRITIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRABECULAR BONE; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CHONDROCYTES; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; MICE, KNOCKOUT; OSTEOGENESIS; RNA, MESSENGER;

EID: 41049114515     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-008-9110-0     Document Type: Article

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